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Shchegolev A.I.

Institut khirurgii im. A.V. Vishnevskogo, Moskva

Lyapin V.M.

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia;
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia

Tumanova U.N.

Institut khirurgii im. A.V. Vishnevskogo Minzdravsotsrazvitiia RF, Moskva

Vodneva D.N.

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia

Shmakov R.G.

Federal State Budget Institution «Research Center for Obstetrics, Gynecology and Perinatology» Ministry of Healthcare of the Russian Federation, Moscow, Russia

Histological hanges in the placenta and vascularization of its villi in early- and late-onset preeclampsia

Authors:

Shchegolev A.I., Lyapin V.M., Tumanova U.N., Vodneva D.N., Shmakov R.G.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2016;78(1): 13‑18

DOI: 10.17116/patol201678113-18

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HISTOLOGICAL HANGES IN THE PLACENTA AND VASCULARIZATION OF ITS VILLI IN EARLY- AND LATE-ONSET PREECLAMPSIA
HISTOLOGICAL HANGES IN THE PLACENTA AND VASCULARIZATION OF ITS VILLI IN EARLY- AND LATE-ONSET PREECLAMPSIA

To cite this article:

Shchegolev AI, Lyapin VM, Tumanova UN, Vodneva DN, Shmakov RG. Histological hanges in the placenta and vascularization of its villi in early- and late-onset preeclampsia. Russian Journal of Archive of Pathology. 2016;78(1):13‑18. (In Russ.)
https://doi.org/10.17116/patol201678113-18

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Objective: to make a comparative histological study of the placenta and a morphometric analysis of its terminal villi in early- and late-onset preeclampsia. Material and methods. Placentae from patients whose pregnancy had been complicated by the development of early- (n=26) or late-onset (n=84) preeclampsia were examined. A control group comprised placentae from 28 patients with physiological pregnancy and no extragenital diseases. The authors made a comparative histological study of placental tissue and a morphometric analysis of the terminal villi using the sections immunohistochemically stained for CD31. Results. It was determined that there was a preponderance of branching angiogenesis in the preeclamptic chorionic villi and an increase in the number of syncytial nodules and microcysts in the septae in late-onset preeclampsia. Morphometric analysis of immunohistochemical placental specimens established a reduction in the sizes and vascularization indicators of terminal villi that determine the development of placental hypoxia and are more pronounced in cases of early-onset preeclampsia.

Keywords:

vascularization
chorionic villi
placenta
preeclampsia

Authors:

Shchegolev A.I.

Institut khirurgii im. A.V. Vishnevskogo, Moskva

Lyapin V.M.

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia;
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia

Tumanova U.N.

Institut khirurgii im. A.V. Vishnevskogo Minzdravsotsrazvitiia RF, Moskva

Vodneva D.N.

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia

Shmakov R.G.

Federal State Budget Institution «Research Center for Obstetrics, Gynecology and Perinatology» Ministry of Healthcare of the Russian Federation, Moscow, Russia

Close metadata

References:

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