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Zavalishina L.É.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Andreeva Yu.Yu.

Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia

Vinogradov I.Iu.

GUZ "Riazanskiĭ oblastnoĭ klinicheskiĭ onkologicheskiĭ dispanser"

Danilova N.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava RF;
GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia", Moskva

Kuznetsova O.A.

Kafedra akusherstva i ginekologii Volgogradskogo gosudarstvennogo meditsinskogo universiteta

Frank G.A.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

Comparative study of the determination of the HER2 status in gastric cancer in the biopsy and intraoperative specimens

Authors:

Zavalishina L.É., Andreeva Yu.Yu., Vinogradov I.Iu., Danilova N.V., Kuznetsova O.A., Frank G.A.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2014;76(6): 22‑27

DOI: 10.17116/patol201476622-27

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COMPARATIVE STUDY OF THE DETERMINATION OF THE HER2 STATUS IN GASTRIC CANCER IN THE BIOPSY AND INTRAOPERATIVE SPECIMENS
COMPARATIVE STUDY OF THE DETERMINATION OF THE HER2 STATUS IN GASTRIC CANCER IN THE BIOPSY AND INTRAOPERATIVE SPECIMENS

To cite this article:

Zavalishina LÉ, Andreeva YuYu, Vinogradov IIu, Danilova NV, Kuznetsova OA, Frank GA. Comparative study of the determination of the HER2 status in gastric cancer in the biopsy and intraoperative specimens. Russian Journal of Archive of Pathology. 2014;76(6):22‑27. (In Russ.)
https://doi.org/10.17116/patol201476622-27

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Objective - to determine the HER2 status of gastric adenocarcinomas, by using biopsy and intraoperative specimens. Subjects and methods. Immunohistochemistry and in situ hybridization were used to examine the HER2 status of 346 gastric cancer biopsy and intraoperative specimens. Results. The study conducted on a large Russian sample of 346 patients showed a positive HER2 status in 10.7% of the examined specimens. Intestinal-type adenocarcinomas exhibited a positive HER2 status in 21.4% of the cases. Comparative analysis of the HER2 status in the biopsy and intraoperative specimens indicated that there were differences in the determination of the tumor HER2 status in less than 1% of the examined specimens. The remaining found differences (14.7%) failed to change the tumor HER2 status and to affect the choice of a treatment regimen. Conclusion. The performed investigation has demonstrated that the tumor HER2 status determined in the biopsy specimen significantly reflects the molecular biological properties of gastric cancer and may be clinically used to determine indications for the use of targeted drugs.

Keywords:

gastric cancer
HER2 status

Authors:

Zavalishina L.É.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Andreeva Yu.Yu.

Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia

Vinogradov I.Iu.

GUZ "Riazanskiĭ oblastnoĭ klinicheskiĭ onkologicheskiĭ dispanser"

Danilova N.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava RF;
GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia", Moskva

Kuznetsova O.A.

Kafedra akusherstva i ginekologii Volgogradskogo gosudarstvennogo meditsinskogo universiteta

Frank G.A.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

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References:

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