The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 101-59-87
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2024
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Ivanova A.S.

GBOU VPO "Ivanovskaia gosudarstvennaia meditsinskaia akademiia" Minzdrava Rossii

Peretiatko L.P.

FGBU "Ivanovskiĭ NII materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii

Demidov V.I.

Ivanovskaia gosudarstvennaia meditsinskaia akademiia, Ivanovo

Nazarov12 S.B.

GBOU VPO "Ivanovskaia gosudarstvennaia meditsinskaia akademiia" Minzdrava Rossii;
FGBU "Ivanovskiĭ NII materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii

Effect of nitric oxide on the morphology of the placenta and the activity of placental macrophages during uncomplicated pregnancy in the experiment

Authors:

Ivanova A.S., Peretiatko L.P., Demidov V.I., Nazarov12 S.B.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2014;76(4): 35‑38

Views: 1126

Downloaded: 45

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Ivanova AS, Peretiatko LP, Demidov VI, Nazarov12 SB. Effect of nitric oxide on the morphology of the placenta and the activity of placental macrophages during uncomplicated pregnancy in the experiment. Russian Journal of Archive of Pathology. 2014;76(4):35‑38. (In Russ.)

Подписка 2025 (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Close metadata
Recommended articles:
Lung pathology in children with a long-term novel coro­navirus infe­ction COVID-19. Russian Journal of Archive of Pathology. 2024;(1):36-43
Methodological approaches to the morphological study of placenta, extraplacental membranes and umbi­lical cord in infe­ctious pathology. Russian Journal of Archive of Pathology. 2024;(5):53-59
New coro­navirus infe­ction in the II trimester of pregnancy: peri­natal and mate­rnal consequences. Russian Bulletin of Obstetrician-Gynecologist. 2023;(6):34-41
Anti­microbial defe­nse of the vagina in reproductive age women (mini-review). Russian Journal of Human Reproduction. 2023;(6):95-101
Impact of inha­led gas compound on nitric dioxide release in a model of nitric oxide inha­lation therapy (experimental study). Russian Journal of Anesthesiology and Reanimatology. 2024;(1):23-30
Fetus-acardius: two obse­rvations from practice with a brief lite­rature review. Russian Bulletin of Obstetrician-Gynecologist. 2024;(2):81-85
Pecu­liarities of local mRNA gene expression of pro- and anti-inflammatory cyto­kines in term pregnancy. Russian Bulletin of Obstetrician-Gynecologist. 2024;(3):6-13
The role of dopa­mine rece­ptors in the modu­lation of mono­nuclear phagocytes in multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7-2):79-84

Objective - to study the effects of nitric oxide (NO) on the morphology of the placenta and the activity of placental macrophages during uncomplicated pregnancy in albino rats. Material and methods. The animals were divided into 3 groups. Group included animals with uncomplicated pregnancy; Group 2 was given drinking water containing 0.2% sodium nitrate on day 1 of pregnancy; Group 3 was intramuscularly injected with the NO synthesis inhibitor Nw-nitro-L-arginine methyl ester (L-NAME) in a dose of 10 mg/kg on day 1 of pregnancy. The central portion of hematoxylin- and eosin-stained placentas was morphologically examined. The activity of placental macrophages was assessed by incubating them with autologous erythrocytes. Results. Pathological examinations of the placentas reveal that when sodium nitrite and L-NAME enter the animal body, structural changes in the placental show that there are maternal and placental circulatory disorders concurrent with dystrophic and destructive processes. Conclusion. The activity of placental macrophages in the examined groups is diametrically opposite.

Keywords:

nitric oxide
placenta
morphology
macrophages

Authors:

Ivanova A.S.

GBOU VPO "Ivanovskaia gosudarstvennaia meditsinskaia akademiia" Minzdrava Rossii

Peretiatko L.P.

FGBU "Ivanovskiĭ NII materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii

Demidov V.I.

Ivanovskaia gosudarstvennaia meditsinskaia akademiia, Ivanovo

Nazarov12 S.B.

GBOU VPO "Ivanovskaia gosudarstvennaia meditsinskaia akademiia" Minzdrava Rossii;
FGBU "Ivanovskiĭ NII materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii

List of references:

  1. Milovanov A.P. Patologiya sistemy mat'-platsenta-plod [Pathology of mother-placenta-fetus system]. Moscow: Meditsina Publ.; 1999. 447 p.
  2. Sladek S.M., Magness R.R., Conrad K.P. Nitric oxide and pregnancy. Am. J. Physiol. 1997; 272: 441-63.
  3. Rosselli M., Keller P.J., Dubey R.K. Role of nitric oxide in the biology, physiology and pathophysiology of reproduction. Hum. Reprod. Update. 1998; 4 (1): 3-24.
  4. Ivanova A.S., Popova I.G., Nazarov S.B. Role of nitric oxide in regulating the function of peritoneal macrophages in rats with experimental violation of utero-placental circulation. Biomeditsina. 2012; 2: 61-67.
  5. Ivanova A.S., Sitnikova O.G., Nazarov S.B. Effect of nitric oxide on the activity of peritoneal macrophages in normal pregnancy in white rats. Rossiiskii fiziologicheskii zhurnal im. I.M. Sechenova. 2012; 3: 388-395. (In Russ.)
  6. Sel'kov S.A., Pavlov O.V. Platsentarnye makrofagi [Placental macrophages]. Moscow: KMK Scientific Press; 2007. 186 p.
  7. Ietta F., Wu Y., Romagnoli R. Oxygen regulation of macrophage migration inhibitory factor in human placenta. Am. J. Physiol. Endoсrinol. Metab. 2007; 292: 272-80.
  8. Roth A.C., Herkert G.F., Bercz J.P., Smith M.K. Evaluation of the developmental toxicity of sodium nitrite in Long-Evans rats. Fundam. Appl. Toxicol. 1987; 9 (4): 668-77.
  9. Huang H.-S., Ma M.-Ch., Chen J. Chronic L-arginine administration increases oxidative and nitrosative stress in rat hyperoxaluric kidneys and excessive crystal deposition. Am. J. Physiol. Renal. Physiol. 2008; 295: 388-96.
  10. Mantovani B. Phagocytosis of in vitro-aged erythrocytes - a sharp distinction between activated and normal macrophages. Exp. Cell Res. 1987; 173 (1): 282-6.
  11. Miller M.R., Megson I.L. Recent developments in nitric oxide donor drugs. Br. J. Pharmacol. 2007; 151 (3): 305-21.
  12. Trampont P., Roudier M., Andrea A.M. et al. The placental-umbilical unit in sickle cell disease pregnancy: a model for studying in vivo functional adjustments to hypoxia in humans. Hum. Pathol. 2004; 35 (11): 1353-9.
  13. Crocker I.P., Cooper S., Ong S.C., Baker P.N. Differences in apoptotic susceptibility of cytotrophoblasts and syncytiotrophoblasts in normal pregnancy to those complicated with preeclampsia and intrauterine growth restriction. Am. J. Pathol. 2003; 162: 637-43.
  14. Ivanova A.S., Popova I.G., Nazarov S.B. State of NO-dependent mechanisms in the placenta and fetuses of white rats in normal pregnancy and with damage of utero-placental circulation. Voprosy biologii, meditsiny i farmatsevticheskoi khimii. 2011; 2: 32-35. (In Russ.)
  15. Mikashinovich Z.I., Olempieva E.V. Condition of blood antioxidant status of women in physiological and complicated pregnancy. Byulleten' sibirskoi meditsiny. 2008; 2: 101-105. (In Russ.)
  16. Gonzalez W., Fontaine V., Pueyo M.E. et al. Molecular plasticity of vascular wall during G-Nitro-L-Arginine Methyl Ester-induced hypertension. Modulation of proinflammatory signals. Hypertension. 2000; 36: 103-9.

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register


We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.