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Ivanova A.S.

GBOU VPO "Ivanovskaia gosudarstvennaia meditsinskaia akademiia" Minzdrava Rossii

Peretiatko L.P.

FGBU "Ivanovskiĭ NII materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii

Demidov V.I.

Ivanovskaia gosudarstvennaia meditsinskaia akademiia, Ivanovo

Nazarov S.B.

GBOU VPO "Ivanovskaia gosudarstvennaia meditsinskaia akademiia" Minzdrava Rossii;
FGBU "Ivanovskiĭ NII materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii

Effect of nitric oxide on the morphology of the placenta and the activity of placental macrophages during uncomplicated pregnancy in the experiment

Authors:

Ivanova A.S., Peretiatko L.P., Demidov V.I., Nazarov S.B.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2014;76(4): 35‑38

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Table of contents

EFFECT OF NITRIC OXIDE ON THE MORPHOLOGY OF THE PLACENTA AND THE ACTIVITY OF PLACENTAL MACROPHAGES DURING UNCOMPLICATED PREGNANCY IN THE EXPERIMENT
EFFECT OF NITRIC OXIDE ON THE MORPHOLOGY OF THE PLACENTA AND THE ACTIVITY OF PLACENTAL MACROPHAGES DURING UNCOMPLICATED PREGNANCY IN THE EXPERIMENT

To cite this article:

Ivanova AS, Peretiatko LP, Demidov VI, Nazarov SB. Effect of nitric oxide on the morphology of the placenta and the activity of placental macrophages during uncomplicated pregnancy in the experiment. Russian Journal of Archive of Pathology. 2014;76(4):35‑38. (In Russ.)

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Objective - to study the effects of nitric oxide (NO) on the morphology of the placenta and the activity of placental macrophages during uncomplicated pregnancy in albino rats. Material and methods. The animals were divided into 3 groups. Group included animals with uncomplicated pregnancy; Group 2 was given drinking water containing 0.2% sodium nitrate on day 1 of pregnancy; Group 3 was intramuscularly injected with the NO synthesis inhibitor Nw-nitro-L-arginine methyl ester (L-NAME) in a dose of 10 mg/kg on day 1 of pregnancy. The central portion of hematoxylin- and eosin-stained placentas was morphologically examined. The activity of placental macrophages was assessed by incubating them with autologous erythrocytes. Results. Pathological examinations of the placentas reveal that when sodium nitrite and L-NAME enter the animal body, structural changes in the placental show that there are maternal and placental circulatory disorders concurrent with dystrophic and destructive processes. Conclusion. The activity of placental macrophages in the examined groups is diametrically opposite.

Keywords:

nitric oxide
placenta
morphology
macrophages

Authors:

Ivanova A.S.

GBOU VPO "Ivanovskaia gosudarstvennaia meditsinskaia akademiia" Minzdrava Rossii

Peretiatko L.P.

FGBU "Ivanovskiĭ NII materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii

Demidov V.I.

Ivanovskaia gosudarstvennaia meditsinskaia akademiia, Ivanovo

Nazarov S.B.

GBOU VPO "Ivanovskaia gosudarstvennaia meditsinskaia akademiia" Minzdrava Rossii;
FGBU "Ivanovskiĭ NII materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii

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References:

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