Placental morphology in inherited thrombophilia

Drobinskaia A.N.; Nadeev A.P.; Zhukova V.A.; Pasman N.M.; Karpov M.A.; Teliatnikova N.V.

doi:https://doi.org/

Drobinskaia A.N.

GBOU VPO "Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava Rossii

Nadeev A.P.

GBOU VPO "Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava Rossii

Zhukova V.A.

GBOU VPO "Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava Rossii

Pasman N.M.

Novosibirskiĭ gosudarstvennyĭ universitet

Karpov M.A.

GBOU VPO "Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava Rossii

Teliatnikova N.V.

GBOU VPO "Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava Rossii

Placental morphology in inherited thrombophilia

Authors:

Drobinskaia A.N., Nadeev A.P., Zhukova V.A., Pasman N.M., Karpov M.A., Teliatnikova N.V.

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Journal: Russian Journal of Archive of Pathology. 2014;76(3): 33‑36

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Drobinskaia AN, Nadeev AP, Zhukova VA, Pasman NM, Karpov MA, Teliatnikova NV. Placental morphology in inherited thrombophilia. Russian Journal of Archive of Pathology. 2014;76(3):33‑36. (In Russ.)

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)

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Abstract:

Objective: to study placental morphological changes in inherited thrombophilia. Subject and methods. A morphometric method was used to examine placentas from 37 patients divided into 3 groups: 1) 13 pregnant women with verified inherited thrombophilia; 2) 14 pregnant women with inherited thrombophilia and signs of placental inflammatory manifestations (basal deciduitis, intervillositis, placentitis); 3) 10 women with normal pregnancy (a control group). Results. In inherited thrombophilia, the placentas exhibited morphological manifestations of chronic placental insufficiency as pathological immaturity with a predominance of intermediate differentiated villi and as dissociated maturity of cotyledones, with a substantial reduction in the specialized terminal villi, excessive intervillous fibrinoid formation and villous immuring, evolving pseudoinfarctions, fewer capillaries in the terminal villi, and their increased stromal proportion. At the same time, no significant differences were found in the morphological pattern in inherited thrombophilia concurrent with placental inflammatory changes. Conclusion. In inherited thrombophilia, there is chronic placental insufficiency caused by delayed development of the shaggy chorion.

Keywords:

inherited thrombophilia

placenta

inflammation

morphometry

Authors:

Drobinskaia A.N.

GBOU VPO "Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava Rossii

Nadeev A.P.

GBOU VPO "Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava Rossii

Zhukova V.A.

GBOU VPO "Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava Rossii

Pasman N.M.

Novosibirskiĭ gosudarstvennyĭ universitet

Karpov M.A.

GBOU VPO "Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava Rossii

Teliatnikova N.V.

GBOU VPO "Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava Rossii

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References:

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