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Zavalishina L.É.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Andreeva Yu.Yu.

Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia

Frank G.A.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

Determination of the possibilities of targeted therapy for gastric cancer

Authors:

Zavalishina L.É., Andreeva Yu.Yu., Frank G.A.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2012;74(4): 21‑27

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DETERMINATION OF THE POSSIBILITIES OF TARGETED THERAPY FOR GASTRIC CANCER
DETERMINATION OF THE POSSIBILITIES OF TARGETED THERAPY FOR GASTRIC CANCER

To cite this article:

Zavalishina LÉ, Andreeva YuYu, Frank GA. Determination of the possibilities of targeted therapy for gastric cancer. Russian Journal of Archive of Pathology. 2012;74(4):21‑27. (In Russ.)

Подписка 2025-2 (Russian Journal of Archive of Pathology)
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The objective of the investigation whose results are given in the paper was to compare a few HER2 testing techniques (immunohistochemistry, fluorescence in situ hybridization, and silver in situ hybridization) for adenocarcinomas of the stomach and esophagogastric junction. Different antibody clones and in situ hybridization kits were comparatively analyzed. Recommendations for the use of different testing methods and for the interpretation of their results are given.

Keywords:

gastric cancer
immunohistochemistry
in situ hybridization

Authors:

Zavalishina L.É.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Andreeva Yu.Yu.

Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia

Frank G.A.

Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena Rosmedtekhnologiĭ, Moskva

List of references:

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  2. Lud A.N., Vakhabova Yu.V., Semenov N.N., Gan'shina I.P., Stepanova E.V. Znachenie HER2 statusa pri rake zheludka. Sovrem onkol 2010; 2: 3-6.
  3. Bang Y.-J., van Cutsem E.V., Feyereislova A., Chung H.C. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010; 376: 9742: 687-697.
  4. Barros-Silva J.D., Leitão D., Afonso L. et al. Association of ERBB2 gene status with histopathological parameters and disease-specific survival in gastric carcinoma patients. Br J Cancer 2009; 100: 3: 487-493.
  5. Boers J.E., Meeuwissen H., Methorst N. HER2 status in gastro-oesophageal adenocarcinomas assessed by two rabbit monoclonal antibodies (SP3 and 4B5) and two in situ hybridization methods (FISH and SISH). Histopathology 2011; 58: 3: 383-394.
  6. García-García E., Gómez-Martín C., Angulo B. et al. Hybridization for human epidermal growth factor receptor 2 testing in gastric carcinoma: a comparison of fluorescence in-situ hybridization with a novel fully automated dual-colour silver in-situ hybridization method. Histopathology 2011; 59: 1: 8-17.
  7. Gravalos C., Jimeno A. HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target. Ann Oncol 2008; 19: 9: 1523-1529.
  8. Hede K. Gastric cancer: trastuzumab trial results spur search for other targets. J Natl Cancer Inst 2009; 101: 19: 1306-1307.
  9. Hoffman M., Stoss O., Shi D. et al. Assessment of a HER2 scoring system for gastric cancer: results from a validation study. Histopathology 2008; 52: 797-805.
  10. Kim M.A., Jung E.J., Lee H.S., Lee H.E., Jeon Y.K., Yang H.K., Kim W.H. Evaluation of HER-2 gene status in gastric carcinoma using immunohistochemistry, fluorescence in situ hybridization, and real-time quantitative polymerase chain reaction. Hum Pathol 2007; 38: 1386-1393.
  11. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965; 64: 31-49.
  12. Moelans C.B., van Diest P.J., Milne A.N., Offerhaus G.J. HER-2/neu testing and therapy in gastroesophageal adenocarcinoma. Pathol Res Int 2010; 2011: 674182.
  13. Park D.I., Yun J.W., Park J.H. et al. HER-2/neu amplification is an independent prognostic factor in gastric cancer. Dig Dis Sci 2006; 51: 1371-1379.
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  16. Slamon D.J., Leyland-Jones B. et al. Use of chemotherapy plus a monoclonal antibody against her2 for metastatic breast cancer that overexpresses HER-2. N Engl J Med 2001; 344: 11: 783-792.
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