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Pal'tseva E.M.

Laboratoriia élektronnoĭ mikroskopii i immunogistokhimii Tsentralizovannogo patologoanatomicheskogo otdeleniia GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdravsotsrazvitiia Rossii

Samofalova O.Iu.

Rossiĭskiĭ nauchnyĭ tsentr khirurgii im. akad. B.V. Petrovskogo RAMN, Moskva

Gorbacheva Iu.V.

Laboratoriia élektronnoĭ mikroskopii i immunogistokhimii Tsentralizovannogo patologoanatomicheskogo otdeleniia GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdravsotsrazvitiia Rossii

Tsar'kov P.V.

Chair of Cardiovascular Surgery and Interventional Cardiology, I.M. Sechenov First Moscow State Medical University (head — MD R.N. Komarov), acad. B.V. Petrovsky Russian Research Center for Surgery (director — acad. of RAS Yu.V. Belov), Moscow, Russia

Expression of some biomarkers in primary colon adenocarcinomas and their lymph node metastases

Authors:

Pal'tseva E.M., Samofalova O.Iu., Gorbacheva Iu.V., Tsar'kov P.V.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2012;74(4): 12‑20

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Table of contents

EXPRESSION OF SOME BIOMARKERS IN PRIMARY COLON ADENOCARCINOMAS AND THEIR LYMPH NODE METASTASES
EXPRESSION OF SOME BIOMARKERS IN PRIMARY COLON ADENOCARCINOMAS AND THEIR LYMPH NODE METASTASES

To cite this article:

Pal'tseva EM, Samofalova OIu, Gorbacheva IuV, Tsar'kov PV. Expression of some biomarkers in primary colon adenocarcinomas and their lymph node metastases. Russian Journal of Archive of Pathology. 2012;74(4):12‑20. (In Russ.)

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
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Abstract:

The samples of colon adenocarcinomas (CAC) and their lymph node metastases from 22 patients were studied. The expression of thymidylate synthase (TS), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), E-cadherin, Β-catenin, tenascin C (TN), and KAI-1/CD82 in primary CAC and their lymph node metastases was compared using an immunohistochemical method. The expression of TS, VEGF, EGFR, E-cadherin, TNC, and KAI-1 was statistically significant different in primary CAC and involved lymph nodes. Comparison of the expression of the markers in the pairs of primary CAC and metastasis revealed equal values for TNC and EFGR in 45.5 and 41% of cases, respectively; the number of coincidences in the expression of the other markers was insignificant. Determination of the expression of molecular biological markers in primary CAC and their lymph nodes may serve as a predictor of therapy response and have a prognostic value.

Keywords:

colon adenocarcinoma
lymph node metastases
immunohistochemistry

Authors:

Pal'tseva E.M.

Laboratoriia élektronnoĭ mikroskopii i immunogistokhimii Tsentralizovannogo patologoanatomicheskogo otdeleniia GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdravsotsrazvitiia Rossii

Samofalova O.Iu.

Rossiĭskiĭ nauchnyĭ tsentr khirurgii im. akad. B.V. Petrovskogo RAMN, Moskva

Gorbacheva Iu.V.

Laboratoriia élektronnoĭ mikroskopii i immunogistokhimii Tsentralizovannogo patologoanatomicheskogo otdeleniia GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdravsotsrazvitiia Rossii

Tsar'kov P.V.

Chair of Cardiovascular Surgery and Interventional Cardiology, I.M. Sechenov First Moscow State Medical University (head — MD R.N. Komarov), acad. B.V. Petrovsky Russian Research Center for Surgery (director — acad. of RAS Yu.V. Belov), Moscow, Russia

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