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Potapov A.L.

Tsyba Medical Radiological Research Center

Dzagkoev D.M.

Tsyb Medical Radiological Research Center — National Medical Research Center of Radiology

Voltov A.A.

Tsyb Medical Radiological Research Center — National Medical Research Center of Radiology

Dorozhkin A.D.

Tsyb Medical Radiological Research Center — National Medical Research Center of Radiology

Khudyakov P.A.

Tsyb Medical Radiological Research Center — National Medical Research Center of Radiology

Isaev P.A.

Tsyb Medical Radiological Research Center — National Medical Research Center of Radiology

Effect of selective opioid agonist taphalgin on the risk of nausea and vomiting after thyroid surgery in young non-smoking females

Authors:

Potapov A.L., Dzagkoev D.M., Voltov A.A., Dorozhkin A.D., Khudyakov P.A., Isaev P.A.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2025;(5): 37‑41

DOI: 10.17116/anaesthesiology202505137

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Table of contents

EFFECT OF SELECTIVE OPIOID AGONIST TAPHALGIN ON THE RISK OF NAUSEA AND VOMITING AFTER THYROID SURGERY IN YOUNG NON-SMOKING FEMALES
EFFECT OF SELECTIVE OPIOID AGONIST TAPHALGIN ON THE RISK OF NAUSEA AND VOMITING AFTER THYROID SURGERY IN YOUNG NON-SMOKING FEMALES

To cite this article:

Potapov AL, Dzagkoev DM, Voltov AA, Dorozhkin AD, Khudyakov PA, Isaev PA. Effect of selective opioid agonist taphalgin on the risk of nausea and vomiting after thyroid surgery in young non-smoking females. Russian Journal of Anesthesiology and Reanimatology. 2025;(5):37‑41. (In Russ.)
https://doi.org/10.17116/anaesthesiology202505137

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Abstract:

The problem of postoperative nausea/vomiting (PONV) remains actual, especially for high risk patients.

OBJECTIVE

To analyze the effect of premedication with trimeperidine and taphalgin on the risk of PONV after thyroid surgery in young non-smoking females.

MATERIAL AND METHODS

There were 70 non-smoking female patients younger 50 years after thyroid surgery: group 1 (n=35) — premedication with trimeperidine, group 2 (n=35) — premedication with selective agonist of μ1 opioid receptors (taphalgin). The incidence and intensity of PONV within a day after surgery were assessed.

RESULTS

The absolute risk of postoperative nausea was 71.4% (95% CI 55.0—85.4%) and 31.4% (95% CI 16.9—48.2%) (p=0.0008), vomiting — 48.6% (95% CI 31.8—55.5%) and 22.9% (95% CI 10.3—38.6%) (p=0.023), respectively. The absolute risk reduction for nausea and vomiting was 40% (95% CI 16.6—57.8%) and 25.7% (95% CI 3.3—0.95%), respectively. The NNT score was 2.5 (95% CI 1.7—6.0) for nausea and 3.9 (95% CI 2.2—30.6) for vomiting. NRS scores of nausea were similar in both groups: 4 (3—6) and 4 (2—4) points, respectively (p=0.36). Course of anesthesia and early postoperative period, including the incidence of other complications, did not differ between groups.

CONCLUSION

Premedication with taphalgin instead of trimeperidine is advisable in patients with high risk of PONV.

Keywords:

anesthesia
premedication
postoperative nausea and vomiting
trimeperidine
taphalgin

Authors:

Potapov A.L.

Tsyba Medical Radiological Research Center

Dzagkoev D.M.

Tsyb Medical Radiological Research Center — National Medical Research Center of Radiology

Voltov A.A.

Tsyb Medical Radiological Research Center — National Medical Research Center of Radiology

Dorozhkin A.D.

Tsyb Medical Radiological Research Center — National Medical Research Center of Radiology

Khudyakov P.A.

Tsyb Medical Radiological Research Center — National Medical Research Center of Radiology

Isaev P.A.

Tsyb Medical Radiological Research Center — National Medical Research Center of Radiology

Received:

03.06.2025

Accepted:

28.07.2025

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