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Bykova K.M.

Almazov National Medical Research Centre

Savvina I.A.

Polenov Neurosurgical Institute;
Mechnikov North-West State Medical University

Rutkovsky R.V.

Almazov National Medical Research Center

Rodchenko A.M.

Almazov National Medical Research Center

Neuroinflammation in perioperative brain dysfunction

Authors:

Bykova K.M., Savvina I.A., Rutkovsky R.V., Rodchenko A.M.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2022;(6): 99‑106

DOI: 10.17116/anaesthesiology202206199

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To cite this article:

Bykova KM, Savvina IA, Rutkovsky RV, Rodchenko AM. Neuroinflammation in perioperative brain dysfunction. Russian Journal of Anesthesiology and Reanimatology. 2022;(6):99‑106. (In Russ.)
https://doi.org/10.17116/anaesthesiology202206199

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The number of elderly patients undergoing anesthesia and surgery is being increased along with aging of population and development of medical technologies. Perioperative cognitive impairment is a common complication, especially in elderly patients. Postoperative delirium is the most severe and acute event predisposing to long-term cognitive impairment. Experimental and clinical studies in the last decade demonstrate that maintaining the integrity of blood-brain barrier is essential for homeostasis of central nervous system. Specific laboratory markers, imaging techniques and omics technologies provide us with evidence that surgery and anesthesia induce neuroinflammation associated with blood-brain barrier dysfunction, microglial activation and neuronal damage.

Keywords:

neuroinflammation
perioperative cognitive disorders
postoperative delirium
postoperative cognitive dysfunction
blood-brain barrier

Authors:

Bykova K.M.

Almazov National Medical Research Centre

Savvina I.A.

Polenov Neurosurgical Institute;
Mechnikov North-West State Medical University

Rutkovsky R.V.

Almazov National Medical Research Center

Rodchenko A.M.

Almazov National Medical Research Center

Received:

27.05.2022

Accepted:

14.06.2022

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