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Vasilitsyna A.V.

Saint Petersburg University, Dept of Anaesthesiology & Intensive Care, 199034, Saint Petersburg, Russia ,Saint-Petersburg I.I. Dzhanelidze research institute of emergency medicine, 192242, Saint Petersburg, Russia

Afonchikov V.S.

I.I. Dzhanelidze St. Petersburg Research Institute of Ambulance, St. Petersburg, Russia

Volchkov V.A.

Saint Petersburg University, Dept of Anaesthesiology &

The determination of platelet functional activity using the method of modified tromboelastography in patients with sepsis

Authors:

Vasilitsyna A.V., Afonchikov V.S., Volchkov V.A.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2019;(3): 56‑61

DOI: 10.17116/anaesthesiology201903156

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THE DETERMINATION OF PLATELET FUNCTIONAL ACTIVITY USING THE METHOD OF MODIFIED TROMBOELASTOGRAPHY IN PATIENTS WITH SEPSIS
THE DETERMINATION OF PLATELET FUNCTIONAL ACTIVITY USING THE METHOD OF MODIFIED TROMBOELASTOGRAPHY IN PATIENTS WITH SEPSIS

To cite this article:

Vasilitsyna AV, Afonchikov VS, Volchkov VA. The determination of platelet functional activity using the method of modified tromboelastography in patients with sepsis. Russian Journal of Anesthesiology and Reanimatology. 2019;(3):56‑61. (In Russ.)
https://doi.org/10.17116/anaesthesiology201903156

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Abstract:

Objective — the sepsis is characterized by systemic response of the organism on the disseminated bacterial infection. The system of hemostasis reacts by formation of diffuse microthrombs, causing the interruption of microcirculation and leading to multiorgan dysfunction. The activation and interaction of different cells of blood (platelets, neutrophils, lymphocytes) play a significant role in the development of procoagulant condition through different pathogenetic mechanisms: to detect the cellular (platelet) activation in the patients with sepsis, in which the modified method of tromboelastography (TEG) has been used. Furthermore, the influence of hemostasis activation on the frequency of development of multiorgan failure has been estimated. Material and methods. The 60 patients have been divided into two groups: the Group 1 consisted of 36 patients with sepsis and the multiorgan failure, while the Group 2 consisted of 24 patients with uncomplicated infections and without the signs of a multiorgan dysfunction. The routine coagulation tests (prothrombin index Quick’s value, activated partial thromboplastin time (aPTT), fibrinogen testing included), platelet count and modified thromboelastography method has been performed in every patient. The samples of whole blood and platelet-poor plasma have been examined simultaneously. The modified method of thromboelastography provided the differentiation of both cellular and plasma part of coagulation system. Results. The parameters of TEG in the patients with sepsis and multiorgan failure are characterized by the presence of hypercoagulation condition. Moreover they reflect the hemostasis activation. Conclusion. The activation of coagulation system plays a significant role in development of sepsis. It is manifested by formation of microtrombs and followed by multiorgan failure. The fact that there is no significant differences in the results of routine coagulation tests, during the comparison between the groups, shows their low sensibility as a diagnostic method for septic coagulopathy. However the usages of global coagulation tests are allowing determination of both signs of hypercoagulation.

Keywords:

sepsis
coagulopathy
thromboelastography
hypercoagulation
platelets activation

Authors:

Vasilitsyna A.V.

Saint Petersburg University, Dept of Anaesthesiology & Intensive Care, 199034, Saint Petersburg, Russia ,Saint-Petersburg I.I. Dzhanelidze research institute of emergency medicine, 192242, Saint Petersburg, Russia

Afonchikov V.S.

I.I. Dzhanelidze St. Petersburg Research Institute of Ambulance, St. Petersburg, Russia

Volchkov V.A.

Saint Petersburg University, Dept of Anaesthesiology &

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References:

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