The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Bakhtadze M.A.

Research Institute of General Pathology and Pathophysiology;
Pirogov Russian National Research Medical University;
Rehabilitation Clinics “Quality of Life”

Berdnikova A.V.

Alexander Vein Clinic of Headache and Autonomic Disorders

Kukushkin M.L.

Research Institute of General Pathology and Pathophysiology

The Central Sensitization Inventory: modification for tension-type headache, migraine and cervicogenic headache

Authors:

Bakhtadze M.A., Berdnikova A.V., Kukushkin M.L.

More about the authors

Journal: Russian Journal of Pain. 2025;23(3): 22‑32

Read: 389 times


To cite this article:

Bakhtadze MA, Berdnikova AV, Kukushkin ML. The Central Sensitization Inventory: modification for tension-type headache, migraine and cervicogenic headache. Russian Journal of Pain. 2025;23(3):22‑32. (In Russ.)
https://doi.org/10.17116/pain20252303122

Recommended articles:
Oxidative stress in the pathogenesis of chro­nic headache. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):35-40
The follow-up examination of children with breath-holding spells. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11-2):76-80
The rela­tionship of diet and nutrition with the frequency of migraine atta­cks. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):30-35
Biochemical features of migraine pathogenesis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4):21-26
The effect of inso­mnia therapy on treatment outcomes in patients with chro­nic tension headache. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):77-83

References:

  1. Mayer TG, Neblett R, Cohen H, Howard KJ, Choi YH, Williams MJ, Perez Y, Gatchel RJ. The development and psychometric validation of the central sensitization inventory. Pain Pract. 2012 Apr;12(4):276-285. Epub 2011 Sept 27. PMID: 21951710; PMCID: PMC3248986. https://doi.org/10.1111/j.1533-2500.2011.00493.x
  2. Bakhtadze MA, Kukushkin ML, Filatova EG, Latisheva NV, Proskuryakov KV, Berdnikova AV. Russian language version of the Central sensitization inventory: validity and reliability of the questionnaire for nonspecific neck pain and headaches. Russian Journal of Pain. 2022;20(1):12-20. (In Russ.).
  3. Bakhtadze MA, Kukushkin ML, Churyukanov MV, Davydov OS, Proskuryakov KV, Kachanovsky MS. Russian language version of the Central sensitization inventory: validity and reliability of the questionnaire for chronic nonspecific neck and back pain. Russian Journal of Pain. 2021;19(3):12-20. (In Russ.). https://doi.org/10.17116/pain20211903112
  4. Kukushkin ML. Mechanisms of chronic pain development. Approaches to prevention and treatment. Consilium Medicum. 2017;19(2):110-117. (In Rus.).
  5. Yakhno NN, Kukushkin ML. Medico-biologic and sotsio-economic aspects. Vestnik Rossijskoj academii meditsinskikh nauk = Annals of Russian Academy of Medical Sciences. 2012; 67(9):54-58. (In Russ.).
  6. Nishigami T, Tanaka K, Mibu A, Manfuku M, Yono S, Tanabe A. Development and psychometric properties of short form of central sensitization inventory in participants with musculoskeletal pain: A cross-sectional study. PLoS One. 2018;13(7):e0200152. https://doi.org/10.1371/journal.pone.0200152
  7. Kirshner B, Guyatt G. A methodological framework for assessing health indices. J Chronic Dis. 1985;38(1):27-36.  https://doi.org/10.1016/0021-9681(85)90005-0
  8. Leonova MV. Patient reported ourcomes in clinical studis. Kachestvennaya klinicheskaya praktika. 2016;2:38-45. (In Russ.).
  9. Neblett R. The central sensitization inventory: A user’s manual. Journal of Applied Biobehavioral Research. 2018;23(2):e12123. https://doi.org/10.1111/jabr.12123
  10. FDA. Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims: draft guidance. Health and Quality of Life Outcomes. 2006;4(1):79  https://doi.org/10.1186/1477-7525-4-79
  11. Terwee CB, Bot SD, de Boer MR, van der Windt DA, Knol DL, Dekker J, Bouter LM, de Vet HC. Quality criteria were proposed for measurement properties of health status questionnaires. Journal of Clinical Epidemiology. 2007 Jan;60(1):34-42. Epub 2006 Aug 24. PMID: 17161752. https://doi.org/10.1016/j.jclinepi.2006.03.012
  12. Tanaka K, Nishigami T, Mibu A, Manfuku M, Yono S, Yukioka S, Miki K. Cutoff Value for Short Form of Central Sensitization Inventory. Pain Practice. 2020;20(3):269-276.  https://doi.org/10.1111/papr.12850
  13. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629-808.  https://doi.org/10.1177/0333102413485658
  14. Kochetov AG, Lyang OV, Masenko VP, Zhirov IV, Nakonechnikov SN, Tereshchenko SN. Methods of statistical processing of medical data. Methodical recommendations for residents, postgraduate students of medical educational institutions, researchers. Moscow: RKNPK; 2012.
  15. Kregel J, Vuijk PJ, Descheemaeker F, Keizer D, van der Noord R, Nijs J, Cagnie B, Meeus M, van Wilgen P. The Dutch Central Sensitization Inventory (CSI): Factor Analysis, Discriminative Power, and Test-Retest Reliability. The Clinical Journal of Pain. 2016 July;32(7):624-630. PMID: 26418360. https://doi.org/10.1097/ajp.0000000000000306
  16. Caumo W, Antunes LC, Elkfury JL, Herbstrith EG, Busanello Sipmann R, Souza A, Torres IL, Souza Dos Santos V, Neblett R. The Central Sensitization Inventory validated and adapted for a Brazilian population: psychometric properties and its relationship with brain-derived neurotrophic factor. Journal of Pain Research. 2017 Sept 01;10:2109-2122. PMID: 28979158; PMCID: PMC5589103. https://doi.org/10.2147/JPR.S131479
  17. Klute M, Laekeman M, Kuss K, Petzke F, Dieterich A, Leha A, Neblett R, Ehrhardt S, Ulma J, Schäfer Axel. Cross-cultural adaptation and validation of the German Central Sensitization Inventory (CSI-GE). BMC Musculoskeletal Disorders. 2021;22(1). https://doi.org/10.1186/s12891-021-04481-5
  18. Ashina S, Bendtsen L, Lyngberg AC, Lipton RB, Hajiyeva N, Jensen R. Prevalence of neck pain in migraine and tension-type headache: a population study. Cephalalgia. 2015;35(3):211-219.  https://doi.org/10.1177/0333102414535110
  19. Ashina S, Bendtsen L, Burstein R, Iljazi A, Jensen RH, Lipton RB. Pain sensitivity in relation to frequency of migraine and tension-type headache with or without coexistent neck pain: an exploratory secondary analysis of the population study. Scand J Pain. 2022 Sept 26;23(1):76-87. PMID: 36137215. https://doi.org/10.1515/sjpain-2022-0030
  20. Zenkevich AS, Filatova EG, Latysheva NV. Migraine and neck pain: Mechanisms of comorbidity. Neurology, Neuropsychiatry, Psychosomatics. 2016;8(1):29-34. (In Russ.). https://doi.org/10.14412/2074-2711-2016-1-29-34
  21. Cuesta-Vargas AI, Neblett R, Nijs J, Chiarotto A, Kregel J, van Wilgen CP, Pitance L, Knezevic A, Gatchel RJ, Mayer TG, Viti C, Roldan-Jiménez C, Testa M, Caumo W, Jeremic-Knezevic M, Nishigami T, Feliu-Soler A, Pérez-Aranda A, Luciano JV. Establishing Central Sensitization-Related Symptom Severity Subgroups: A Multicountry Study Using the Central Sensitization Inventory. Pain Medicine. 2020;21(10):2430-2440. https://doi.org/10.1093/pm/pnaa210
  22. Scerbo T, Colasurdo J, Dunn S, Unger J, Nijs J, Cook C. Measurement Properties of the Central Sensitization Inventory: A Systematic Review. Pain Pract. 2018;18(4):544-554.  https://doi.org/10.1111/papr.12636
  23. Fernández-De-Las-Peñas C, Fernández-Muñoz JJ, Palacios-Ceña M, Parás-Bravo P, Cigarán-Méndez M, Navarro-Pardo E. Sleep disturbances in tension-type headache and migraine. Therapeutic Advances in Neurological Disorders. 2018;11:175628561774544. https://doi.org/10.1177/1756285617745444
  24. Peris F, Donoghue S, Torres F, Mian A, Wöber C. Towards improved migraine management: Determining potential trigger factors in individual patients. Cephalalgia. 2017;37(5):452-463.  https://doi.org/10.1177/0333102416649761
  25. Peres MFP. Hypothalamic involvement in chronic migraine. Journal of Neurology, Neurosurgery and Psychiatry. 2001;71(6):747-751.  https://doi.org/10.1136/jnnp.71.6.747
  26. Karsan N, Goadsby PJ. Migraine Is More Than Just Headache: Is the Link to Chronic Fatigue and Mood Disorders Simply Due to Shared Biological Systems? Frontiers in Human Neuroscience. 2021 June 03;15:646692. https://doi.org/10.3389/fnhum.2021.646692
  27. de Araújo CM, Barbosa IG, Lemos SMA, Domingues RB, Teixeira AL. Cognitive impairment in migraine: A systematic review. Dement Neuropsychol. 2012;6(2):74-79.  https://doi.org/10.1590/s1980-57642012dn06020002
  28. Begasse De Dhaem O, Robbins MS. Cognitive Impairment in Primary and Secondary Headache Disorders. Current Pain and Headache Reports. 2022;26(5):391-404.  https://doi.org/10.1007/s11916-022-01039-5
  29. Cathcart S, Winefield AH, Lushington K, Rolan P. Stress and tension-type headache mechanisms. Cephalalgia. 2010;30(10):1250-1267. https://doi.org/10.1177/0333102410362927
  30. Yang F-C, Lin T-Y, Chen H-J, Lee J-T, Lin C-C, Kao C-H. Increased Risk of Dementia in Patients with Tension-Type Headache: A Nationwide Retrospective Population-Based Cohort Study. PLoS One. 2016;11(6):e0156097. https://doi.org/10.1371/journal.pone.0156097
  31. Kotb MA, Kamal AM, Al-Malki D, Abd El Fatah AS, Ahmed YM. Cognitive performance in patients with chronic tension-type headache and its relation to neuroendocrine hormones. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery. 2020;56(1):16.  https://doi.org/10.1186/s41983-020-0150-3
  32. Qu P, Yu J-X, Xia L, Chen G-H. Cognitive Performance and the Alteration of Neuroendocrine Hormones in Chronic Tension-Type Headache. Pain Practice. 2018;18(1):8-17.  https://doi.org/10.1111/papr.12574
  33. Beech EL, Riddell N, Murphy MJ, Crewther SG. Sex and stress hormone dysregulation as clinical manifestations of hypothalamic function in migraine disorder: A meta‐analysis. European Journal of Neuroscience. 2023;58(4):3150-3171. https://doi.org/10.1111/ejn.16087
  34. Paschali M, Lazaridou A, Rist P, Curiel M, Afsarifard K, Moore S, Bernstein C. Cortisol Awakening Response In Patients With Episodic Migraines Receiving Acceptance And Commitment Therapy. The Journal of Pain. 2023;24(4 Suppl):97-98.  https://doi.org/10.1016/j.jpain.2023.02.278
  35. Song T-J, Cho S-J, Kim W-J, Yang KI, Yun C-H, Chu MK. Anxiety and Depression in Tension-Type Headache: A Population-Based Study. PLoS One. 2016;11(10):e0165316. https://doi.org/10.1371/journal.pone.0165316
  36. Luo J. Association between migraine and anxiety symptoms: Results from the study of women’s health across the nation. Journal of Affective Disorders. 2021;295:1229-1233. https://doi.org/10.1016/j.jad.2021.09.036
  37. Karimi L, Wijeratne T, Crewther SG, Evans AE, Ebaid D, Khalil H. The Migraine-Anxiety Comorbidity Among Migraineurs: A Systematic Review. Front Neurol. 2020;11:613372. https://doi.org/10.3389/fneur.2020.613372
  38. Raudenská J, Macko T, Vodičková Š, Buse DC, Javůrková A. Anxiety Disorders, Anxious Symptomology and Related Behaviors Associated With Migraine: A Narrative Review of Prevalence and Impact. Current Pain and Headache Reports. 2025;29(1):40.  https://doi.org/10.1007/s11916-024-01312-9
  39. Dresler T, Caratozzolo S, Guldolf K, Huhn J-I, Loiacono C, Niiberg-Pikksööt T, Puma M, Sforza G, Tobia A, Ornello R, Serafini G. Understanding the nature of psychiatric comorbidity in migraine: a systematic review focused on interactions and treatment implications. The Journal of Headache and Pain. 2019;20(1):51.  https://doi.org/10.1186/s10194-019-0988-x
  40. Falla K, Kuziek J, Mahnaz SR, Noel M, Ronksley PE, Orr SL. Anxiety and Depressive Symptoms and Disorders in Children and Adolescents With Migraine: A Systematic Review and Meta-analysis. JAMA Pediatrics. 2022;176(12):1176-1187. https://doi.org/10.1001/jamapediatrics.2022.3940
  41. Breslau N, Lipton RB, Stewart WF, Schultz LR, Welch KM. Comorbidity of migraine and depression: investigating potential etiology and prognosis. Neurology. 2003;60(8):1308-1312. https://doi.org/10.1212/01.wnl.0000058907.41080.54
  42. de Vries Lentsch S, Louter MA, van Oosterhout WPJ, van Zwet EW, van Noorden MS, Terwindt GM. Depressive symptoms during the different phases of a migraine attack: A prospective diary study. Journal of Affective Disorders. 2022;297:502-507.  https://doi.org/10.1016/j.jad.2021.10.046
  43. Borsook D, Maleki N, Becerra L, McEwen B. Understanding Migraine through the Lens of Maladaptive Stress Responses: A Model Disease of Allostatic Load. Neuron. 2012;73(2):219-234.  https://doi.org/10.1016/j.neuron.2012.01.001
  44. Rota E, Mongini F. Muscle Tenderness and Psychiatric Comorbidity: A Vicious Cycle in Migraine Chronicization. Frontiers in Neurology. 2014;5.  https://doi.org/10.3389/fneur.2014.00148
  45. Filatova E, Latysheva N, Kurenkov A. Evidence of persistent central sensitization in chronic headaches: a multi-method study. The Journal of Headache and Pain. 2008;9(5):295-300.  https://doi.org/10.1007/s10194-008-0061-7
  46. Wilkins AJ, Haigh SM, Mahroo OA, Plant GT. Photophobia in migraine: A symptom cluster? Cephalalgia. 2021;41(11-12):1240-1248. https://doi.org/10.1177/03331024211014633
  47. ICHD-3. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1-211.  https://doi.org/10.1177/0333102417738202
  48. Terrin A, Mainardi F, Lisotto C, Mampreso E, Fuccaro M, Maggioni F, Zanchin G. A prospective study on osmophobia in migraine versus tension-type headache in a large series of attacks. Cephalalgia. 2020 Apr;40(4):337-346. Epub 2019 Sept 19. PMID: 31537108. https://doi.org/10.1177/0333102419877661
  49. Azimova YuE, Amelin AV, Alferova VV, Artemenko AR, Akhmadeeva LR, Golovacheva VA, Danilov AB, Ekusheva EV, Isagulyan ED, Koreshkina MI, Kurushina OV, Latysheva NV, Lebedeva ER, Naprienko MV, Ostpova VV, Pavlov NA, Parfenov, VA, Rachin AP, Sergeev AV, Skorobogatikh KV, Tabeeva GR, Filatova EG. Clinical guidelines “Migraine”. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(1-3):4-36. (In Russ.). https://doi.org/10.17116/jnevro20221220134
  50. Azimova YuE, Amelin AV, Alferova VV, Artemenko AR, Akhmadeeva LR, Golovacheva VA, Danilov AB, Ekusheva EV, Isagulyan ED, Koreshkina MI, Kurushina OV, Latysheva NV, Lebedeva ER, Naprienko MV, Ostpova VV, Pavlov NA, Parfenov, VA, Rachin AP, Sergeev AV, Skorobogatikh KV, Tabeeva GR, Filatova EG. Clinical guidelines for Clinical Guidelines for Headache Stress. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(1-3):4-28. (In Russ.). https://doi.org/10.17116/jnevro20221220234
  51. Suzuki K, Suzuki S, Shiina T, Kobayashi S, Hirata K. Central Sensitization in Migraine: A Narrative Review. Journal of Pain Research. 2022 Sept 07;15:2673-2682. PMID: 36101891; PMCID: PMC9464439. https://doi.org/10.2147/JPR.S329280

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.