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Tishukov M.Yu.

Georgievsky Medical Academy

Tishukova I.I.

Pirogov Hospital No. 1

Voropaev V.M.

Semashko Republican Clinical Hospital

Muraviev A.V.

Sevastopol City Hospital No. 5 — Center for Maternal and Child Health Protection

Garapov T.A.

Sevastopol City Hospital No. 1

Ignat’ev V.V.

Sevastopol City Hospital No. 5 — Center for Maternal and Child Health Protection

Predictors of mortality in neonatal spontaneous gastric perforation: a multiple-center study

Authors:

Tishukov M.Yu., Tishukova I.I., Voropaev V.M., Muraviev A.V., Garapov T.A., Ignat’ev V.V.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2025;(9): 44‑53

DOI: 10.17116/hirurgia202509144

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Table of contents

PREDICTORS OF MORTALITY IN NEONATAL SPONTANEOUS GASTRIC PERFORATION: A MULTIPLE-CENTER STUDY
PREDICTORS OF MORTALITY IN NEONATAL SPONTANEOUS GASTRIC PERFORATION: A MULTIPLE-CENTER STUDY

To cite this article:

Tishukov MYu, Tishukova II, Voropaev VM, Muraviev AV, Garapov TA, Ignat’ev VV. Predictors of mortality in neonatal spontaneous gastric perforation: a multiple-center study. Pirogov Russian Journal of Surgery. 2025;(9):44‑53. (In Russ.)
https://doi.org/10.17116/hirurgia202509144

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To analyze clinical data and predictors of mortality in neonatal spontaneous gastric perforation (SGP).

MATERIAL AND METHODS

A two-center retrospective cohort study included neonates diagnosed with SGP between 1999 and 2023. This cohort was divided into survivors and dead neonates to identify prognostic factors of mortality.

RESULTS

There were 11 neonates (male-to-female ratio 8:3). Mean gestational age was 33±3.2 weeks. Nine (82%) ones were preterm infants. The mortality rate was 54.5% (6/11), mean age — 7.7 days (range 2—20). The most common signs were abdominal distension and respiratory distress. All patients had pneumoperitoneum upon admission. Concomitant gastrointestinal anomalies were necrotizing enterocolitis (3 patients), gastroschisis (1 patient), and tracheoesophageal fistula (1 patient). Neonatal respiratory distress syndrome (RDS) is a prognostic factor of fatal outcome in patients with SGP. RDS in patients with SGP increases the probability of death by 39 times (OR 39.0; 95% CI 1.3 — 1191; p=0.04).

CONCLUSION

RDS is a prognostic factor of mortality in neonates with SGP. Identification of modifiable prognostic factors of mortality in critical periods of life of neonates with SPG will facilitate effective strategies for prevention and treatment of this pathology.

Keywords:

spontaneous gastric perforation
neonates
gastrointestinal tract anomalies
prognostic factors of mortality
laparotomy

Authors:

Tishukov M.Yu.

Georgievsky Medical Academy

Tishukova I.I.

Pirogov Hospital No. 1

Voropaev V.M.

Semashko Republican Clinical Hospital

Muraviev A.V.

Sevastopol City Hospital No. 5 — Center for Maternal and Child Health Protection

Garapov T.A.

Sevastopol City Hospital No. 1

Ignat’ev V.V.

Sevastopol City Hospital No. 5 — Center for Maternal and Child Health Protection

Received:

04.11.2024

Accepted:

26.12.2024

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