Surgical and combined treatment of patients with craniovertebral junction meningioma: a single-center retrospective study of 196 cases

Shimansky VN, Sultanov RA, Tanyashin SV, et al. . Surgical and combined treatment of patients with craniovertebral junction meningioma: a single-center retrospective study of 196 cases. Burdenko's Journal of Neurosurgery. 2023;87(2):22‑29. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20238702122

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)

Использование инфографики авторами научных работ

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OBJECTIVE

To present the results of surgical and combined treatment of patients with craniovertebral junction meningioma.

MATERIAL AND METHODS

There were 196 patients with craniovertebral junction meningioma who underwent surgical or combined (surgery + radiotherapy) treatment at the Burdenko Neurosurgery Center between January 2005 and June 2022. The sample included 151 women and 45 men (3.4:1). Resection of tumor was performed in 97.4% of patients, craniovertebral junction decompression with dural defect closure — 2%, ventriculoperitoneostomy — 0.5%. As the second stage, 40 patients (20.4%) underwent radiotherapy.

RESULTS

Total resection was achieved in 106 patients (55.2%), subtotal — 63 (32.8%), partial — 20 (10.4%), tumor biopsy was performed in 3 (1.6%) cases. Intraoperative complications occurred in 8 patients (4%), postoperative complications — in 19 (9.7%) cases. Radiosurgery was carried out in 6 (15%) patients, hypofractionated irradiation — 15 (37.5%), standard fractionation — 19 (47.5%) patients. Tumor growth control after combined treatment made up 84%.

CONCLUSION

Clinical outcomes in patients with craniovertebral junction meningioma depend on tumor dimensions, topographic and anatomical localization of tumor, resection quality and relationship with surrounding structures. Combined treatment of anterior and anterolateral meningiomas of the craniovertebral junction is preferable compared to total resection.

Keywords:

meningioma

craniovertebral junction

skull base tumor

posterior cranial fossa

combined treatment

radiosurgery

Authors:

Shimansky V.N.

Burdenko Neurosurgical Center

ORCID: 0000-0002-3816-847X

Sultanov R.A.

Burdenko Neurosurgical Center

Tanyashin S.V.

Burdenko Neurosurgical Center

ORCID: 0000-0001-8351-5074

Golanov A.V.

Burdenko Neurosurgical Center

ORCID: 0000-0002-0976-4547

Galkin M.V.

Burdenko National Medical Research Center for Neurosurgery

SPIN RSCI: 7745-6695
Scopus AuthorID: 36099071200
ResearcherID: AAH-4783-2019
ORCID: 0000-0002-1436-0010

Karnaukhov V.V.

Burdenko Neurosurgical Center

Danilov G.V.

Burdenko Neurosurgical Center

SPIN RSCI: 4140-8998
Scopus AuthorID: 56042615200
ResearcherID: P-6080-2016
ORCID: 0000-0003-1442-5993

Strunina Yu.V.

Burdenko Neurosurgical Center

ORCID: 0000-0003-1696-4050

Received:

14.11.2022

Accepted:

27.01.2023

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