Influence of resection quality on postoperative outcomes in children with atypical teratoid-rhabdoid tumor of the central nervous system

Olkhova LV, Kushel YV, Kadyrov ShU, et al. . Influence of resection quality on postoperative outcomes in children with atypical teratoid-rhabdoid tumor of the central nervous system. Burdenko's Journal of Neurosurgery. 2021;85(2):17‑25. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20218502117

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)

Использование инфографики авторами научных работ

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Abstract:

The purpose of this study was to assess the influence of resection quality on overall survival and disease-free survival in children with atypical teratoid-rhabdoid tumors (ATRT). The study included children younger than 18 years old for the period from 2008 to 2019. There were 134 interventions in 105 patients with ATRT including 11 redo resections («second-look» surgery) and 18 procedures for tumor recurrence. Age of patients ranged from 2 to 168 months (median 21 months). Patients with supratentorial tumors prevailed (50.5%), infratentorial neoplasms were diagnosed in 45.7% of patients, spinal cord lesion — 3.8% of cases. At the first stage, all patients underwent surgical treatment. Total resection was achieved in 34 (32.4%) patients, subtotal — 37 (35.2%) patients, partial resection — 30 (28.6%) patients. Biopsy was performed in 4 (3.8%) patients. Quality of resection and age at surgery significantly influenced overall and disease-free survival. Extended resection of tumor followed by adjuvant chemo- and radiotherapy are required to improve survival although ATRTs are high-grade neoplasms with poor prognosis.

Keywords:

ATRT

children

neurosurgery

neurooncology

Authors:

Olkhova L.V.

Children’s Clinical Hospital of the Pirogov Russian National Medical University

Kushel Y.V.

Burdenko Neurosurgical Center

ORCID: 0000-0001-7136-0693

Kadyrov Sh.U.

Burdenko Neurosurgical Center

RSCI AuthorID: 669386
Scopus AuthorID: 23473552800
ORCID: 0000-0001-5879-1333

Melikyan A.G.

Burdenko Neurosurgical Center

Gorelyshev S.K.

Burdenko Neurosurgical Center

ORCID: 0000-0003-0984-2039

Popov V.E.

Vladimirsky Moscow Regional Research Clinical Institute

SPIN RSCI: 5978-3811
Scopus AuthorID: 57203914025
ORCID: 0000-0003-4835-8047

Shults E.I.

Burdenko Neurosurgical Center

SPIN RSCI: 3255-8587
Scopus AuthorID: 57112078200
ORCID: 0000-0001-5406-944X

Ryzhova M.V.

Burdenko Neurosurgical Center

ORCID: 0000-0001-7206-6365

Zheludkova O.G.

V.F. Voyno-Yasenetsky Scientific and Practical Center of Specialized Medical Care for Children

ORCID: 0000-0002-8607-3635

Received:

04.03.2020

Accepted:

05.02.2021

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References:

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