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Pronin I.N.

Burdenko Neurosurgical Center

Batalov A.I.

Burdenko Neurosurgical Center

Shults E.I.

Burdenko Neurosurgical Center

Mertsalova M.P.

Burdenko Neurosurgical Center

Vikhrova N.B.

Burdenko Neurosurgical Center

Pogosbekyan E.L.

Burdenko Neurosurgical Center

Konakova T.A.

Burdenko National Medical Scientific Center for Neurosurgery

Kornienko V.N.

Burdenko Neurosurgical Center

Phosphorus MR spectroscopy and 18F-FDG PET/CT in the study of energy metabolism of glial tumors

Authors:

Pronin I.N., Batalov A.I., Shults E.I., Mertsalova M.P., Vikhrova N.B., Pogosbekyan E.L., Konakova T.A., Kornienko V.N.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2021;85(2): 26‑33

DOI: 10.17116/neiro20218502126

Read: 2236 times

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Table of contents

PHOSPHORUS MR SPECTROSCOPY AND 18F-FDG PET/CT IN THE STUDY OF ENERGY METABOLISM OF GLIAL TUMORS
PHOSPHORUS MR SPECTROSCOPY AND 18F-FDG PET/CT IN THE STUDY OF ENERGY METABOLISM OF GLIAL TUMORS

To cite this article:

Pronin IN, Batalov AI, Shults EI, et al. . Phosphorus MR spectroscopy and 18F-FDG PET/CT in the study of energy metabolism of glial tumors. Burdenko's Journal of Neurosurgery. 2021;85(2):26‑33. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20218502126

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To study energy metabolism in glial tumors using dynamic MR spectroscopy and 18F-FDG PET/CT.

MATERIAL AND METHODS

The study included 19 patients (9 women and 10 men) with newly diagnosed supratentorial glial tumors WHO Grade I—IV (diffuse astrocytoma — 4 cases, oligodendroglioma — 4 cases, anaplastic astrocytoma — 5 cases, glioblastoma — 6 cases). All patients underwent examination and surgical treatment at the Burdenko Neurosurgery Center. Dynamic MR spectroscopy and 18F-FDG PET/CT were applied in each patient.

RESULTS

We found multiple correlations between the ratio of bioorganic phosphate peaks and parameters of glucose uptake by tumor tissue. These relationships were more significant in patients with high-grade tumors: positive significant correlation between SUVtumor and PME/PCr ratio (RS=0.75, p=0.01), T/Nmix and βATP/Pi ratio (Rs=0.76, p=0.02), SUVpeaktumor and aATP/Pi ratio (RS=0.77, p=0.008). Moreover, there were negative correlations between SUVtumor and PCr/bATP ratio (RS= –0.66, p=0.05), T/Nmix and PDE/bATP ratio (RS= –0.83, p=0.006), SUVpeaktumor and PDE/aATP ratio (RS= –0.76, p=0.009).

CONCLUSION

High-grade gliomas were characterized by higher glucose consumption, ATP release (intensification of energy metabolism) and faster cell membrane synthesis. These processes indicate enhanced proliferation of tumor cells (intensification of plastic metabolism).

Keywords:

glial tumors
phosphorus MR spectroscopy
positron emission tomography with 18F-fluoro-2-deoxy-D-glucose
18F-FDG PET/CT
MRI

Authors:

Pronin I.N.

Burdenko Neurosurgical Center

Batalov A.I.

Burdenko Neurosurgical Center

Shults E.I.

Burdenko Neurosurgical Center

Mertsalova M.P.

Burdenko Neurosurgical Center

Vikhrova N.B.

Burdenko Neurosurgical Center

Pogosbekyan E.L.

Burdenko Neurosurgical Center

Konakova T.A.

Burdenko National Medical Scientific Center for Neurosurgery

Kornienko V.N.

Burdenko Neurosurgical Center

Received:

08.12.2020

Accepted:

05.02.2021

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