The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Pronin I.N.

Burdenko Neurosurgical Center

Batalov A.I.

Burdenko Neurosurgical Center

Shults E.I.

Burdenko Neurosurgical Center

Mertsalova M.P.

Burdenko Neurosurgical Center

Vikhrova N.B.

Burdenko Neurosurgical Center

Pogosbekyan E.L.

Burdenko Neurosurgical Center

Konakova T.A.

Burdenko National Medical Scientific Center for Neurosurgery

Kornienko V.N.

Burdenko Neurosurgical Center

Phosphorus MR spectroscopy and 18F-FDG PET/CT in the study of energy metabolism of glial tumors

Authors:

Pronin I.N., Batalov A.I., Shults E.I., Mertsalova M.P., Vikhrova N.B., Pogosbekyan E.L., Konakova T.A., Kornienko V.N.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2021;85(2): 26‑33

DOI: 10.17116/neiro20218502126

Views: 1553

Downloaded: 35

Download PDF (RU)
Download PDF
Contact the author
Table of contents

To cite this article:

Pronin IN, Batalov AI, Shults EI, et al. . Phosphorus MR spectroscopy and 18F-FDG PET/CT in the study of energy metabolism of glial tumors. Burdenko's Journal of Neurosurgery. 2021;85(2):26‑33. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20218502126

 
МСФ на ЯМ
Close metadata
Recommended articles:
Magnetic reso­nance imaging and PET/CT with 11C-methionine for primary central nervous system vasculitis. Burdenko's Journal of Neurosurgery. 2024;(6):71-76
Analysis of state guarantees for MRI in acco­rdance with procedures for medi­cal care approved by the Mini­stry of Health. Medi­cal Technologies. Asse­ssment and Choice. 2024;(2):69-77
The central vein sign in the differential diagnosis of multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7-2):58-65
Pelvic recu­rrences of ovarian cancer: sono­graphic visualization and magnetic reso­nance imaging. P.A. Herzen Journal of Onco­logy. 2024;(5):31-39
Diagnostic value of cross-sectional imaging moda­lities in asse­ssment of peri­toneal carcinomatosis. P.A. Herzen Journal of Onco­logy. 2024;(5):82-88
Brain microstructural abno­rmalities asse­ssed by diffusion kurtosis MRI in patients with focal temporal lobe epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):171-177

OBJECTIVE

To study energy metabolism in glial tumors using dynamic MR spectroscopy and 18F-FDG PET/CT.

MATERIAL AND METHODS

The study included 19 patients (9 women and 10 men) with newly diagnosed supratentorial glial tumors WHO Grade I—IV (diffuse astrocytoma — 4 cases, oligodendroglioma — 4 cases, anaplastic astrocytoma — 5 cases, glioblastoma — 6 cases). All patients underwent examination and surgical treatment at the Burdenko Neurosurgery Center. Dynamic MR spectroscopy and 18F-FDG PET/CT were applied in each patient.

RESULTS

We found multiple correlations between the ratio of bioorganic phosphate peaks and parameters of glucose uptake by tumor tissue. These relationships were more significant in patients with high-grade tumors: positive significant correlation between SUVtumor and PME/PCr ratio (RS=0.75, p=0.01), T/Nmix and βATP/Pi ratio (Rs=0.76, p=0.02), SUVpeaktumor and aATP/Pi ratio (RS=0.77, p=0.008). Moreover, there were negative correlations between SUVtumor and PCr/bATP ratio (RS= –0.66, p=0.05), T/Nmix and PDE/bATP ratio (RS= –0.83, p=0.006), SUVpeaktumor and PDE/aATP ratio (RS= –0.76, p=0.009).

CONCLUSION

High-grade gliomas were characterized by higher glucose consumption, ATP release (intensification of energy metabolism) and faster cell membrane synthesis. These processes indicate enhanced proliferation of tumor cells (intensification of plastic metabolism).

Keywords:

glial tumors
phosphorus MR spectroscopy
positron emission tomography with 18F-fluoro-2-deoxy-D-glucose
18F-FDG PET/CT
MRI

Authors:

Pronin I.N.

Burdenko Neurosurgical Center

Batalov A.I.

Burdenko Neurosurgical Center

Shults E.I.

Burdenko Neurosurgical Center

Mertsalova M.P.

Burdenko Neurosurgical Center

Vikhrova N.B.

Burdenko Neurosurgical Center

Pogosbekyan E.L.

Burdenko Neurosurgical Center

Konakova T.A.

Burdenko National Medical Scientific Center for Neurosurgery

Kornienko V.N.

Burdenko Neurosurgical Center

Received:

08.12.2020

Accepted:

05.02.2021

List of references:

  1. Andrade CS, Otaduy CG, Park EJ, Leite CC. Phosphorus-31 MR spectroscopy of the human brain: technical aspects and biomedical applications. International Journal of Current Research and Review. 2014;6(9):41-57. 
  2. Hess S, Blomberg BA, Zhu HJ, Høilund-Carlsen PF, Alavi A. The pivotal role of FDG-PET/CT in modern medicine. Academic Radiology. 2014;21(2):232-249.  https://doi.org/10.1016/j.acra.2013.11.002
  3. Heindel W, Bunke J, Glathe S, Steinbrich W, Mollevanger L. Combined 1H-MR imaging and localized 31P-spectroscopy of intracranial tumors in 43 patients. Journal of Computer Assisted Tomography. 1988;12(6):907-916.  https://doi.org/10.1097/00004728-198811000-00001
  4. Hubesch B, Sappey-Marinier D, Roth K, Meyerhoff DJ, Matson GB, Weiner MW. P-31 MR spectroscopy of normal human brain and brain tumors. Radiology. 1990;174(2):401-409.  https://doi.org/10.1148/radiology.174.2.2296651
  5. Arnold DL, Emrich JF, Shoubridge EA, Villemure JG, Feindel W. Characterization of astrocytomas, meningiomas, and pituitary adenomas by phosphorus magnetic resonance spectroscopy. Journal Neurosurgery. 1991;74(3):447-453.  https://doi.org/10.3171/jns.1991.74.3.0447
  6. Maintz D, Heindel W, Kugel H, Jaeger R, Lackner K. Phosphorus-31 MR spectroscopy of normal adult human brain and brain tumours. NMR in Biomedicine. 2002;15(1):18-27.  https://doi.org/10.1002/nbm.735
  7. Esmaeili M, Hamans BC, Navis AC, van Horssen R, Bathen TF, Gribbestad IS, Leenders WP, Heerschap A. IDH1 R132H mutation generates a distinct phospholipid metabolite profile in glioma. Cancer Research. 2014;74(17):4898-4907. https://doi.org/10.1158/0008-5472.CAN-14-0008
  8. Novak J, Wilson M, Macpherson L, Arvanitis TN, Davies NP, Peet AC. Clinical protocols for ³¹P MRS of the brain and their use in evaluating optic pathway gliomas in children. European Journal of Radiology. 2014;83(2):106-112.  https://doi.org/10.1016/j.ejrad.2013.11.009
  9. Pronin IN, Zakharova NE, Podoprigora AE, Batalov AI, Tyurina AN, Mertsalova MP, Fadeeva LM, Golanov AV, Postnov AA, Rodionov PV, Potapov AA. Phosphorus (P) magnetic resonance spectroscopy for evaluation of brain tissue metabolism and measuring non-invasive pH. A study involving 23 volunteers. Part I. Voprosy neirokhirurgii imeni N.N. Burdenko. 2019;83(2):5-10. (In Russ.). https://doi.org/10.17116/neiro2019830
  10. Warburg O, Wind F, Negelein E. The metabolism of tumors in the body. Journal of General Physiology. 1927;8(6):519-530.  https://doi.org/10.1085/jgp.8.6.519
  11. Di Chiro G. Positron emission tomography using [18F] fluorodeoxyglucose in brain tumors. A powerful diagnostic and prognostic tool. Investigative Radiology. 1987;22(5):360-371.  https://doi.org/10.1097/00004424-198705000-00002
  12. Di Chiro G, Brooks RA. PET-FDG of untreated and treated cerebral gliomas. Journal of Nuclear Medicine. 1988;29(3):421-423. 
  13. Patronas NJ, Di Chiro G, Kufta C, Bairamian D, Kornblith PL, Simon R, Larson SM. Prediction of survival in glioma patients by means of positron emission tomography. Journal of Neurosurgery. 1985;62(6):816-822.  https://doi.org/10.3171/jns.1985.62.6.0816
  14. Tyler JL, Diksic M, Villemure JG, Evans AC, Meyer E, Yamamoto YL, Feindel W. Metabolic and hemodynamic evaluation of gliomas using positron emission tomography. Journal of Nuclear Medicine.1987;28(7):1123-1133.
  15. Herholz K, Ziffling P, Staffen W, Pawlik G, Wagner R, Wienhard K, Heiss WD. Uncoupling of hexose transport and phosphorylation in human gliomas demonstrated by PET. European Journal of Cancer and Clinical Oncology. 1988;24(7):1139-1150. https://doi.org/10.1016/0277-5379(88)90120-4
  16. Solivera J, Cerdán S, Pascual JM, Barrios L, Roda JM. Assessment of 31P-NMR analysis of phospholipid profiles for potential differential diagnosis of human cerebral tumors. NMR in Biomedicine. 2009;22(6):663-674.  https://doi.org/10.1002/nbm.1387
  17. Sutton LN, Lenkinski RE, Cohen BH, Packer RJ, Zimmerman RA. Localized 31P magnetic resonance spectroscopy of large pediatric brain tumors. Journal of Neurosurgery. 1990;72(1):65-70.  https://doi.org/10.3171/jns.1990.72.1.0065
  18. Bulakbasi N, Kocaoglu M, Sanal HT, Tayfun C. Efficacy of in vivo 31Phosphorus Magnetic Resonance Spectroscopy in Differentiation and Staging of Adult Human Brain Tumors. The Neuroradiology Journal. 2007;20(6):646-655.  https://doi.org/10.1177/197140090702000608
  19. Cadoux-Hudson TA, Blackledge MJ, Rajagopalan B, Taylor DJ, Radda GK. Human primary brain tumour metabolism in vivo: a phosphorus magnetic resonance spectroscopy study. British Journal of Cancer. 1989;60:430-436.  https://doi.org/10.1038/bjc.1989.300
  20. Lehnhardt FG, Röhn G, Ernestus RI, Grüne M, Hoehn M. 1H- and (31)P-MR spectroscopy of primary and recurrent human brain tumors in vitro: malignancy-characteristic profiles of water soluble and lipophilic spectral components. NMR in Biomedicine. 2001;14(5):307-317.  https://doi.org/10.1002/nbm.708
  21. Hattingen E, Bähr O, Rieger J, Blasel S, Steinbach J, Pilatus U. Phospholipid metabolites in recurrent glioblastoma: in vivo markers detect different tumor phenotypes before and under antiangiogenic therapy. Public Library of Science One. 2013;8(3):1-10.  https://doi.org/10.1371/journal.pone.0056439
  22. Kemp GJ. Non-invasive methods for studying brain energy metabolism: what they show and what it means. Developmental Neuroscience. 2000;22(5-6):418-428.  https://doi.org/10.1159/000017471
  23. Steen RG. Characterization of tumor hypoxia by 31P MR spectroscopy. American Journal of Roentgenology. 1991;157(2):243-248.  https://doi.org/10.2214/ajr.157.2.1853799
  24. Fais S, Venturi G, Gatenby B. Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy. Cancer and Metastasis Reviews. 2014;33(4):1095-1108. https://doi.org/10.1007/s10555-014-9531-3
  25. Schornack PA, Gillies RJ. Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors. Neoplasia. 2003;5(2):135-145.  https://doi.org/10.1016/s1476-5586(03)80005-2
  26. Kamble RB, Peruvumba NJ, Shivashankar R. Energy status and metabolism in intracranial space occupying lesions: a prospective 31p spectroscopic study. Journal of Clinical and Diagnostic Research. 2014;8(11):RC05-RC8.  https://doi.org/10.7860/JCDR/2014/10176.5139
  27. Arnold DL, Shoubridge EA, Feindel W, Villemure JG. Metabolic changes in cerebral gliomas within hours of treatment with intra-arterial BCNU demonstrated by phosphorus magnetic resonance spectroscopy. Canadian Journal of Neurological Sciences. 1987;14(4):570-575.  https://doi.org/10.1017/S0317167100037380

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.