Surgical management of brain metastases following female reproductive system cancers: analysis of 37 cases

Sevyan N.V.; Karakhan V.B.; Prozorenko E.V.; Bekyashev A.Kh.; Mitrofanov A.A.

doi:https://doi.org/10.17116/neiro20218501156

Sevyan N.V.

Blokhin National Cancer Medical Research Center;
Sechenov First Moscow State Medical University

Karakhan V.B.

Blokhin National Cancer Medical Research Center

Prozorenko E.V.

Sechenov First Moscow State Medical University

Bekyashev A.Kh.

Blokhin National Cancer Medical Research Center

SPIN RSCI: 1140-1406
Scopus AuthorID: 15729212400
ORCID: 0000-0002-4160-9598

Mitrofanov A.A.

Mental Health Research Center

Surgical management of brain metastases following female reproductive system cancers: analysis of 37 cases

Authors:

Sevyan N.V., Karakhan V.B., Prozorenko E.V., Bekyashev A.Kh., Mitrofanov A.A.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2021;85(1): 56‑67

DOI: 10.17116/neiro20218501156

Read: 2691 times

To cite this article:

Sevyan NV, Karakhan VB, Prozorenko EV, Bekyashev AKh, Mitrofanov AA. Surgical management of brain metastases following female reproductive system cancers: analysis of 37 cases. Burdenko's Journal of Neurosurgery. 2021;85(1):56‑67. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20218501156

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)

Использование инфографики авторами научных работ

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OBJECTIVE

To demonstrate an appropriateness and role of neurosurgical care in the complex management of women with brain metastases following reproductive system cancers.

MATERIAL AND METHODS

There were 78 women with brain metastases following reproductive system cancer. All patients were treated at the Blokhin National Cancer Medical Research Center for the period 2004—2019. We have also reviewed the literature data for the last 30 years.

Results and discussion. Resection of brain metastases in complex treatment of endometrial, ovarian and cervical cancer ensured favorable long-term survival in our material. Thus, mean life expectancy after resection of brain metastases was 16.3 months in patients with ovarian cancer, uterine cancer — 15.6 months, cervical cancer — 10.25 months. Obviously, surgery is not indicated in all cases. However, this approach improves local control and should be used in combination with other treatment methods for improvement of life expectancy and its quality in certain patients.

CONCLUSION

Selective surgical approach should be essential in the treatment of patients with brain metastases following reproductive system cancer. A multidisciplinary approach ensures the best treatment outcomes.

Keywords:

brain metastases

ovarian cancer

endometrial cancer

cervical cancer

surgical neurooncology

Authors:

Sevyan N.V.

Blokhin National Cancer Medical Research Center;
Sechenov First Moscow State Medical University

Karakhan V.B.

Blokhin National Cancer Medical Research Center

Prozorenko E.V.

Sechenov First Moscow State Medical University

Bekyashev A.Kh.

Blokhin National Cancer Medical Research Center

SPIN RSCI: 1140-1406
Scopus AuthorID: 15729212400
ORCID: 0000-0002-4160-9598

Mitrofanov A.A.

Mental Health Research Center

Received:

16.06.2020

Accepted:

02.11.2020

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References:

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