The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Oshorov A.V.

Burdenko Neurosurgical Center

Polupan A.A.

Burdenko Neurosurgical Center

Sychev A.A.

Burdenko Neurosurgical Center

Baranich A.I.

Burdenko Neurosurgical Center

Kurdyumova N.V.

Burdenko Neurosurgical Center

Abramov T.A.

Burdenko Neurosurgical Center

Savin I.A.

Burdenko Neurosurgical Center

Potapov A.A.

Burdenko Neurosurgical Center

Influence of cerebral hyperthermia on intracranial pressure and autoregulation of cerebral circulation in patients with acute brain injury

Authors:

Oshorov A.V., Polupan A.A., Sychev A.A., Baranich A.I., Kurdyumova N.V., Abramov T.A., Savin I.A., Potapov A.A.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2021;85(1): 68‑77

DOI: 10.17116/neiro20218501168

Views: 3624

Downloaded: 95

Download PDF (RU)
Download PDF
Contact the author
Table of contents

INFLUENCE OF CEREBRAL HYPERTHERMIA ON INTRACRANIAL PRESSURE AND AUTOREGULATION OF CEREBRAL CIRCULATION IN PATIENTS WITH ACUTE BRAIN INJURY
INFLUENCE OF CEREBRAL HYPERTHERMIA ON INTRACRANIAL PRESSURE AND AUTOREGULATION OF CEREBRAL CIRCULATION IN PATIENTS WITH ACUTE BRAIN INJURY

To cite this article:

Oshorov AV, Polupan AA, Sychev AA, et al. . Influence of cerebral hyperthermia on intracranial pressure and autoregulation of cerebral circulation in patients with acute brain injury. Burdenko's Journal of Neurosurgery. 2021;85(1):68‑77. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20218501168

Подписка 2025-2 (Burdenko's Journal of Neurosurgery)
 
МСФ на ЯМ
Close metadata
Recommended articles:
Arti­ficial ventilation in patients with stroke: main resu­lts of the Russian multicenter obse­rvational clinical trial RETAS. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(8-2):5-13
Pathophysiologic mechanisms and risk factors of hype­rthermia in labor asso­ciated with epidural analgesia. (Data of a prospective study). Russian Bulletin of Obstetrician-Gynecologist. 2024;(4):13-20
Intracranial hype­rtension in hemo­rrhagic stroke: a single-center retrospective study. Russian Journal of Anesthesiology and Reanimatology. 2024;(6):23-29

Background. Hyperthermia is a common symptom in ICU patients with brain injury.

OBJECTIVE

To study the effect of hyperthermia on intracranial pressure (ICP) and cerebral autoregulation (Prx).

MATERIAL AND METHODS

There were 8 patients with acute brain injury, signs of brain edema and intracranial hypertension. Cerebral autoregulation was assessed by using of PRx. ICP, CPP, BP, PRx were measured before and during hyperthermia. We have analyzed 33 episodes of cerebral hyperthermia over 38.30 C. Statistica 10.0 (StatSoft) was used for statistical analysis.

RESULTS

Only ICP was significantly increased by 6 [3; 11] mm Hg (p<0.01). In patients with initially normal ICP, hyperthermia resulted increase of ICP in 48% of cases (median 24 [22; 28] mm Hg). In patients with baseline intracranial hypertension, progression of hypertension was noted in 100% cases (median 31 [27; 32] mm Hg) (p<0.01). Hyperthermia resulted intracranial hypertension regardless brain autoregulation status.

CONCLUSION

Cerebral hyperthermia in patients with initially normal ICP results intracranial hypertension in 48% of cases. In case of elevated ICP, further progression of intracranial hypertension occurs in 100% of cases. Cerebral hyperthermia is followed by ICP elevation in both intact and impaired cerebral autoregulation.

Keywords:

hyperthermia
intracranial pressure
intracranial hypertension
cerebral blood flow autoregulation

Authors:

Oshorov A.V.

Burdenko Neurosurgical Center

Polupan A.A.

Burdenko Neurosurgical Center

Sychev A.A.

Burdenko Neurosurgical Center

Baranich A.I.

Burdenko Neurosurgical Center

Kurdyumova N.V.

Burdenko Neurosurgical Center

Abramov T.A.

Burdenko Neurosurgical Center

Savin I.A.

Burdenko Neurosurgical Center

Potapov A.A.

Burdenko Neurosurgical Center

Received:

23.03.2020

Accepted:

28.08.2020

List of references:

  1. Niven D, Laupland K. Pyrexia: aetiology in the ICU. Critical Care. 2016;20(1):247.  https://doi.org/10.1186/s13054-016-1406-2
  2. Andrews P, Verma V, Healy M, Lavinio A, Curtis C, Reddy U, Andrzejowski J, Foulkes A, Canestrini S. Targeted temperature management in patients with intracerebral haemorrhage, subarachnoid haemorrhage, or acute ischaemic stroke: consensus recommendations. British Journal of Anaesthesia. 2018;121(4):768-775.  https://doi.org/10.1016/j.bja.2018.06.018
  3. Greer D, Funk S, Reaven N, Ouzounelli M, Uman G. Neurologic injury: a comprehensive meta-analysis. Stroke. 2008;39(11):3029-3036. https://doi.org/0.1161/STROKEAHA.108.521583
  4. Madden LK, Hill M, May TL, Human T, Guanci MM, Jacobi J, Moreda MV, Badjatia N. The implementation of targeted temperature management: an evidence-based guideline from the Neurocritical Care Society. Neurocritical Care. 2017;27(3):468-487.  https://doi.org/10.1007/s12028-017-0469-5
  5. Scaravilli V, Tinchero G, Citerio G; Participants in the International Multi-Disciplinary Consensus Conference on the Critical Care Management of Subarachnoid Hemorrhage. Fever management in SAH. Neurocritical Care. 2011;15(2):287-294.  https://doi.org/10.1007/s12028-011-9588-6
  6. Badjatia N. Fever Control in the NeuroICU: Why, Who and When? Current Opinion in Critical Care. 2009;15(2):79-82.  https://doi.org/10.1097/MCC.0b013e32832922e9
  7. Prasad K, Krishnan P. Fever is associated with doubling of odds of short-term mortality in ischemic stroke: an updated meta-analysis. Acta Neurologica Scandinavica. 2010;122(6):404-408.  https://doi.org/10.1111/j.1600-0404.2010.01326.x
  8. Hajat C, Hajat S, and Sharma P. Effects of Poststroke Pyrexia on Stroke Outcome: A Meta-Analysis of Studies in Patients. Stroke. 2000;31(2):410-414.  https://doi.org/10.1161/01.str.31.2.410
  9. Fernandez A, Schmidt JM, Claassen J, Pavlicova M, Huddleston D, Kreiter KT, Ostapkovich ND, Kowalski RG, Parra A, Connolly ES, Mayer SA. Fever after subarachnoid hemorrhage: risk factors and impact on outcome. Neurology. 2007;68(3):1013-1019. https://doi.org/10.1212/01mnl.0000258543.45879.f5
  10. Springer M, Schmidt J, Wartenberg K, Frontera J, Badjatia N, Mayer S. Predictors of Global Cognitive Impairment 1 Year after Subarachnoid Hemorrhage. Neurosurgery. 2009;65(6):1043-1051. https://doi.org/10.1227/01.NEU.0000359317.15269.20
  11. Stocchetti N, Rossi S, Zanier ER, Colombo A, Beretta L, Citerio G. Pyrexia in head-injured patients admitted to intensive care. Intensive Care Medicine. 2002;28(11):1555-1562. https://doi.org/10.1007/s00134-002-1513-1
  12. Childs C, Lunn KW. Clinical review: Brain-body temperature differences in adults with severe traumatic brain injury. Critical Care. 2013;17(2):222.  https://doi.org/10.1186/cc11892
  13. Huschak G, Hoell T, Wiegel M, Hohaus C, Stuttmann R, Meisel HJ, Mast H. Does brain temperature correlate with intracranial pressure? Journal of Neurosurgical Anesthesiology. 2008;20(2):105-109.  https://doi.org/10.1097/ANA.0b013e31815f528c
  14. Nyholm L, Howells T, Lewén A, Hillered L, Enblad P. The influence of hyperthermia on intracranial pressure, cerebral oximetry and cerebral metabolism in traumatic brain injury. Upsala Journal of Medical Sciences. 2017;122(3):177-184.  https://doi.org/10.1080/03009734.2017.1319440
  15. Rossi S, Zanier ER, Mauri I, Columbo A, Stocchetti N. Brain temperature, body core temperature, and intracranial pressure in acute cerebral damage. Journal of Neurology, Neurosurgery, and Psychiatry. 2001;71(4):448-454.  https://doi.org/10.1136/jnnp.71.4.448
  16. Busto R, Dietrich WD, Globus MY, Ginsberg MD. The importance of brain temperature in cerebral ischemic injury. Stroke. 1989;20:1113-1114. https://doi.org/10.1161/01.str.20.8.1113
  17. Mellergard P, Nordstrom C. Intracerebral temperature in neurosurgical patients. Neurosurgery. 1991;28:709-713. 
  18. Takagi K, Ginsberg MD, Globus MY, Martinez E, Busto R. Effect of hyperthermia on glutamate release in ischemic penumbra after middle cerebral artery occlusion in rats. The American Journal of Physiology. 1994;267(5 Pt 2):1770-1776. https://doi.org/10.1152/ajpheart.1994.267.5.H1770
  19. Globus MY, Busto R, Lin B, Schnippering H, Ginsberg MD. Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation. Journal of Neurochemistry. 1995;65(3):1250-1256. https://doi.org/10.1046/j.1471-4159.1995.65031250.x
  20. Clasen R, Pandolfi S, Laing I, Casey D Jr. Experimental study of relationof fever to cerebral edema. Journal of Neurosurgery. 1974;41(5):576-581.  https://doi.org/10.3171/jns.1974.41.5.0576
  21. Morimoto T, Ginsberg MD, Dietrich WD, Zhao W. Hyperthermia enhances spectrin breakdown in transient focal cerebral ischemia. Brain Research. 1997;746(1-2):43-51.  https://doi.org/10.1016/s0006-8993(96)01154-7
  22. Kiyatkin EA. Brain temperature: from physiology and pharmacology to neuropathology. Handbook of Clinical Neurology. 2018;157:483-504.  https://doi.org/10.1016/B978-0-444-64074-1.00030-6
  23. Oshorov A., Savin I., Popugaev K., Potapov A. Influence of hyperthermia on the parameters of MAP, CPP and Prx in patients with severe TBI. Brain Injury. 2014;28(5-6):797.  https://doi.org/10.3109/02699052.2014.892379
  24. Stretti F, Gotti M, Pifferi S, Brandi G, Annoni F, Stocchetti N. Body temperature affects cerebral hemodynamics in acutely brain injured patients: an observational transcranial color-coded duplex sonography study. Critical Care. 2014;18(5):552.  https://doi.org/10.1186/s13054-014-0552-7

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.