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Mertsalova M.P.

Burdenko Neurosurgical Center

Pronin I.N.

Burdenko Neurosurgical Center

Zakharova N.E.

Burdenko Neurosurgical Center

Podoprigora A.E.

Burdenko Neurosurgical Center

Batalov A.I.

Burdenko Neurosurgical Center

Tyurina A.N.

Burdenko Neurosurgical Center

Shults E.I.

Burdenko Neurosurgical Center

Pogosbekyan E.L.

Burdenko Neurosurgical Center

Fadeeva L.M.

Burdenko Neurosurgical Center

Golanov A.V.

Burdenko Neurosurgical Center

Postnov A.A.

Burdenko National Medical Scientific Center for Neurosurgery;
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute);
Lebedev Physical Institute of the Russian Academy of Sciences

Rodionov P.V.

Burdenko Neurosurgical Center

Intracellular pH measurement in glioblastoma cells: the possibilities of phosphorus-31 MR spectroscopy

Authors:

Mertsalova M.P., Pronin I.N., Zakharova N.E., Podoprigora A.E., Batalov A.I., Tyurina A.N., Shults E.I., Pogosbekyan E.L., Fadeeva L.M., Golanov A.V., Postnov A.A., Rodionov P.V.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2020;84(6): 26‑32

DOI: 10.17116/neiro20208406126

Views: 1790

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To cite this article:

Mertsalova MP, Pronin IN, Zakharova NE, et al. . Intracellular pH measurement in glioblastoma cells: the possibilities of phosphorus-31 MR spectroscopy. Burdenko's Journal of Neurosurgery. 2020;84(6):26‑32. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20208406126

 
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OBJECTIVE

To analyze intracellular pH measurement with phosphorus-31 MR spectroscopy in glioblastoma cells and to compare these data with intracellular pH in healthy volunteers.

MATERIAL AND METHODS

There were 10 patients aged 41 — 67 years with supratentorial glioblastomas. Intracellular pH in glioblastoma cells was compared with pH in healthy persons.

RESULTS

We found a tendency to increased intracellular pH in glioblastoma cells in comparison with pH in intact brain tissue.

CONCLUSION

Intracellular pH in brain tissue can be used as a potential marker of early abnormalities which could not be detected by conventional MRI. Moreover, these data may be valuable to estimate the efficacy of chemotherapy. The study was supported by Russian Science Foundation (grant №18-15-00337)

Keywords:

MR spectroscopy
brain metabolism
intracellular pH
glioblastoma

Authors:

Mertsalova M.P.

Burdenko Neurosurgical Center

Pronin I.N.

Burdenko Neurosurgical Center

Zakharova N.E.

Burdenko Neurosurgical Center

Podoprigora A.E.

Burdenko Neurosurgical Center

Batalov A.I.

Burdenko Neurosurgical Center

Tyurina A.N.

Burdenko Neurosurgical Center

Shults E.I.

Burdenko Neurosurgical Center

Pogosbekyan E.L.

Burdenko Neurosurgical Center

Fadeeva L.M.

Burdenko Neurosurgical Center

Golanov A.V.

Burdenko Neurosurgical Center

Postnov A.A.

Burdenko National Medical Scientific Center for Neurosurgery;
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute);
Lebedev Physical Institute of the Russian Academy of Sciences

Rodionov P.V.

Burdenko Neurosurgical Center

Received:

08.06.2020

Accepted:

28.08.2020

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