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Moskvina E.A.

Department of Oncological Neurosurgery, Blokhin Russian Cancer Research Center, Moscow, Russia

Naskhletashvili D.R.

Department of Oncological Neurosurgery, Blokhin Russian Cancer Research Center, Moscow, Russia

Bekiashev A.Kh.

FGBU "Rossiĭskiĭ nauchnyĭ onkologicheskiĭ tsentr im. N.N. Blokhina" RAMN, Moskva, Rossiia

Medvedev S.V.

Department of Oncological Neurosurgery, Blokhin Russian Cancer Research Center, Moscow, Russia

Belov D.M.

Department of Oncological Neurosurgery, Blokhin Russian Cancer Research Center, Moscow, Russia

Gasparyan T.G.

Department of Oncological Neurosurgery, Blokhin Russian Cancer Research Center, Moscow, Russia

A clinical case of combined treatment of a patient with breast cancer and metastases to the brain and meninges

Authors:

Moskvina E.A., Naskhletashvili D.R., Bekiashev A.Kh., Medvedev S.V., Belov D.M., Gasparyan T.G.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2016;80(1): 83‑87

DOI: 10.17116/neiro201680183-87

Views: 6073

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Table of contents

A CLINICAL CASE OF COMBINED TREATMENT OF A PATIENT WITH BREAST CANCER AND METASTASES TO THE BRAIN AND MENINGES
A CLINICAL CASE OF COMBINED TREATMENT OF A PATIENT WITH BREAST CANCER AND METASTASES TO THE BRAIN AND MENINGES

To cite this article:

Moskvina EA, Naskhletashvili DR, Bekiashev AKh, Medvedev SV, Belov DM, Gasparyan TG. A clinical case of combined treatment of a patient with breast cancer and metastases to the brain and meninges. Burdenko's Journal of Neurosurgery. 2016;80(1):83‑87. (In Russ., In Engl.)
https://doi.org/10.17116/neiro201680183-87

Подписка 2025-2 (Burdenko's Journal of Neurosurgery)
 
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The article describes a clinical case of successful chemotherapeutic and radiation treatment of a patient with breast cancer and metastases to the brain and meninges and with a pronounced neurological deficit. The patient underwent combined treatment (whole brain radiation with TBD of 30 Gy and local radiation of a metastasis with TBD of 15 Gy associated with capecitabine therapy) with continued administration of capecitabine until improvement. A partial metastasis reduction by 50% and complete regression of the neurological deficit were observed. Disease-free period was 1 year and 10 months, and the overall survival amounted to 2 years.

Keywords:

breast cancer
brain metastases
meningeal metastases
chemoradiotherapy

Authors:

Moskvina E.A.

Department of Oncological Neurosurgery, Blokhin Russian Cancer Research Center, Moscow, Russia

Naskhletashvili D.R.

Department of Oncological Neurosurgery, Blokhin Russian Cancer Research Center, Moscow, Russia

Bekiashev A.Kh.

FGBU "Rossiĭskiĭ nauchnyĭ onkologicheskiĭ tsentr im. N.N. Blokhina" RAMN, Moskva, Rossiia

Medvedev S.V.

Department of Oncological Neurosurgery, Blokhin Russian Cancer Research Center, Moscow, Russia

Belov D.M.

Department of Oncological Neurosurgery, Blokhin Russian Cancer Research Center, Moscow, Russia

Gasparyan T.G.

Department of Oncological Neurosurgery, Blokhin Russian Cancer Research Center, Moscow, Russia

List of references:

  1. Cardoso F, Senkus-Konefka E, Fallowfield L, Costa A, Castiglione M. Locally recurrent or metastatic breast cancer. Clinical Practice Guidelines for diagnosis, treatment and follow-up. ESMO. Ann?ls of Oncology. 2010;21(Suppl 5):15-19. doi: 10.1093/annonc/mdq160
  2. Wood WC, Muss HB, Solin LJ, Olopade OI. Cancer of the breast. In: DeVita VTJr, Hellman S, Rosenberg SA. (eds). Cancer Principles & Practice of Oncology. Philadelphia: PA, Lippincott Williams & Wilkins. 2005;1453-1462.
  3. Delattre JY, Krol G, Thaler HT, Posner JB. Distribution of brain metastases. Arch Neurol. 1988;45(7):741-744.
  4. Lee YT. Breast carcinoma: pattern of metastasis at autopsy. Surgical Oncology. 1983;23(3):175-180. doi: 10.1002/jso.2930230311
  5. DiStefano A, Yong Yap Y, Hortobagyi GN, Blumenschein GR. The natural history of breast cancer patients with brain metastases. Cancer. 1979;44(5):1913-1918.
  6. Posner JB. Back pain and epidural spinal cord compression. Med Clin North Am. 1987;71:185-205.
  7. Chowdhary S, Chamberlain M. Leptomeningeal metastases: current concepts and management guidelines. Natl Compr Canc Netw. 2005;3(5):693-703.
  8. Grossman SA, Krabak MJ. Leptomeningeal - carcinomatosis. Cancer Treatment Rev. 1999;25(2):103-119.
  9. Chamberlain MC. Neoplastic meningitis. Neurologist. 2006;12(4):179-187.
  10. Herrlinger U, Forschler H, Kuker W, Meyermann R, Bamberg M, Dichgans J, Weller M. Leptomeningeal metastasis: survival and prognostic factors in 155 patients. J Neurol Sci. 2004;30:223(2):167-178. doi: 0.1016_j.jns.2004.05.008
  11. Lee SS, Ahn JH, Kim MK, Sym SJ, Gong G, Ahn SD, Kim SB, Kim WK. Brain metastases in breast cancer: prognostic factors and management. Breast Cancer Research and Treatment. 2008;111(3):523-530. doi: 10.1007/s10549-007-9806-2

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