Basal ganglia germinomas in children. Four clinical cases and a literature review

Konovalov A.N.; Kadyrov Sh.U.; Tarasova E.M.; Mazerkina N.A.; Gorelyshev S.K.; Khukhlaeva E.A.; Kobiakov G.L.; Trunin Yu.Yu.; Sanakoeva A.V.; Kholodov B.V.; Shishkina L.V.; Panina T.N.; Ryzhova M.V.

doi:https://doi.org/10.17116/neiro201680171-82

Konovalov A.N.

Burdenko Neurosurgical Institute, Moscow, Russian Federation

Kadyrov Sh.U.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Tarasova E.M.

FGBU "Nauchno-issledovatel'skiĭ institut neĭrokhirurgii im. akad. N.N. Burdenko" RAMN

Mazerkina N.A.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko", Moskva

Gorelyshev S.K.

GBU NII neĭrokhirurgii im. N.N. Burdenko

Khukhlaeva E.A.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Kobiakov G.L.

GBU NII neĭrokhirurgii im. N.N. Burdenko

Trunin Yu.Yu.

Burdenko Neurosurgical Institute, Moscow, Russian Federation

Sanakoeva A.V.

Burdenko Neurosurgical Institute, Moscow, Russia

Kholodov B.V.

GBU NII neĭrokhirurgii im. N.N. Burdenko

Shishkina L.V.

Burdenko Neurosurgery Institute, Moscow, Russia

ORCID: 0000-0001-7045-7223

Panina T.N.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Ryzhova M.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Basal ganglia germinomas in children. Four clinical cases and a literature review

Authors:

Konovalov A.N., Kadyrov Sh.U., Tarasova E.M., Mazerkina N.A., Gorelyshev S.K., Khukhlaeva E.A., Kobiakov G.L., Trunin Yu.Yu., Sanakoeva A.V., Kholodov B.V., Shishkina L.V., Panina T.N., Ryzhova M.V.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2016;80(1): 71‑82

DOI: 10.17116/neiro201680171-82

Read: 3052 times

To cite this article:

Konovalov AN, Kadyrov ShU, Tarasova EM, et al. . Basal ganglia germinomas in children. Four clinical cases and a literature review. Burdenko's Journal of Neurosurgery. 2016;80(1):71‑82. (In Russ., In Engl.)
https://doi.org/10.17116/neiro201680171-82

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)

Использование инфографики авторами научных работ

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Abstract:

Basal ganglia germinomas are a specific group of intracranial germinomas. Their early diagnosis is complicated due to their atypical localization and diversity of neuroimaging and clinical signs. Material and methods. We describe 4 cases of basal ganglia germinoma in boys of 13, 14, 15, and 16 years of age. The medical history data, clinical features, neuroimaging and histological characteristics of basal ganglia germonomas, and preliminary results of the treatment are presented. Conclusion. Basal ganglia germinomas are usually verified at the late stage of the disease when patients are detected with extended lesions of the basal ganglia and severe neurological and neuroendocrine deficits. This situation is due to clinical and imaging signs that are untypical of common germinomas.

Keywords:

basal ganglia germinoma

clinical signs

diagnosis

Authors:

Konovalov A.N.

Burdenko Neurosurgical Institute, Moscow, Russian Federation

Kadyrov Sh.U.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Tarasova E.M.

FGBU "Nauchno-issledovatel'skiĭ institut neĭrokhirurgii im. akad. N.N. Burdenko" RAMN

Mazerkina N.A.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko", Moskva

Gorelyshev S.K.

GBU NII neĭrokhirurgii im. N.N. Burdenko

Khukhlaeva E.A.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Kobiakov G.L.

GBU NII neĭrokhirurgii im. N.N. Burdenko

Trunin Yu.Yu.

Burdenko Neurosurgical Institute, Moscow, Russian Federation

Sanakoeva A.V.

Burdenko Neurosurgical Institute, Moscow, Russia

Kholodov B.V.

GBU NII neĭrokhirurgii im. N.N. Burdenko

Shishkina L.V.

Burdenko Neurosurgery Institute, Moscow, Russia

ORCID: 0000-0001-7045-7223

Panina T.N.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Ryzhova M.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

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References:

Osuka S, Tsuboi K, Takano S, Ishikawa E, Matsushita A, Tok- Uuye K, Akine Y, Matsumura A. Long-term outcome of patients with intracranial germinoma. J of Neurooncology. 2007;83:71-79.
Ramelli G.P, Vonder Weid N., Stanga Z., Mullis P.E., Buergi U. Suprasellar germinomas in childhood and adolescence: Diagnostic pitfalls. J of pediatric endocrinology & metabolis. 1998;11:693-697.
Tamaki N, Lin T, Shirataki K, Hosoda K, Kurata H, Matsumoto S, Ito H. Germcell tumors of the thalamus and the basal ganglia. Childs Nervous System. 1990;6:3-7.
Matsutani M, Sano K, Takakura K, Fujimaki T, Nakamura O, Funata N, Seto T. Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verifled cases. J of neurosurgery. 1997;86:446-455.
Kim CH, Paek SH, Park IA, Chi JG, Kim DG. Cerebral Germinoma with hemiatrophy of the brain: report of three cases. Acta Neurochirurgica (Wien). 2002;144:145-150.
Takeda N, Fujita K, Katayama S, Uchihashi Y, Okamura Y, Nigami H, Hashimoto K, Kohmura E. Germinoma of the basal ganglia. An 8-year asymptomatic history after detection of abnormality on CT. Pediatric Neurosurgery. 2004;40:306-311. 7. Kawai N, Miyake K, Nishiyama Y, Yamamoto Y, Miki A, Haba R, Imai T, Tamiya T, Nagao S. Targeting optimal biopsy location in basal ganglia germinoma using (11) C-methionine positron emission tomography. Surgical Neurology. 2008;70:408-413.
Moon WK, Chang KH, Kim IO, Han MH, Choi CG, Suh DC, Yoo SJ, Han MC. Germinomas of the basal ganglia and thalamus: MR findings and a comparison between MR and CT. American J of Roentgenology. 1994;162:1413-1417.
Sonoda Y, Kumabe T, Sugiyama S, Kanamori M, Yamashita Y, Saito R., Ariga H, Takai Y, Tominaga T. Germcell tumors in the basal ganglia: Problems of early diagnosis and treatment. J of Neurosurgery: Pediatrics. 2008;2:118-124. doi: 10.3171/PED/2008/2/8/118
Phi JH, Cho B-K, Kim S-K, Paeng JC, Kim I-O, Kim IH, Kim DG, Jung HW, Kim JE, Wang KC. Germinomas in the basal ganglia: magnetic resonance imaging classification and the prognosis. J of Neurooncology. 2010;99:227-236. doi: 10.1007/s11060-010-0119-7
Utsuki S., Oka H., TanizakiY., Kondo K., Fujii K. Radiological features of germinoma arising from atypical locations. Neurologia Medica-chirurgica (Tokyo). 2005;45:268-271.
Wang KC, Kim SK, Park SH, Kim IO, Cho BK. Intracranial germcell tumors. In: Tonn JC, Westphal M, Rutka JT. Neurooncology of CNS tumors. Springer. (Berlin). 2006;517-527.
Birnbaum T, Pellkofer H, Buettner U. Intracranial germinoma clinically mimicking chronic progressive multiple sclerosis. J of Neurolology. 2008;255:775-776. doi: 10.1007/s00415-008-0811-0
Ozelame RV, Shroff M, Wood B, Bouffet E, Bartels U, Drake JM. Hawkins C., Blaser S. Basal ganglia germinoma in children with associated ipsilateral cerebral and brainstem hemiatrophy. Pediatric Radiology. 2006;36:325-330.
Okamoto K, Ito J, Ishikawa K, Morii K, Yamada M, Takahashi N, Tokiguchi S, Furusawa T, Sakai K. Atrophy of the basal ganglia as the initial diagnostic sign of germinoma in the basal ganglia. Neuroradiology. 2002;44:389-394.
Tang J, Ma Z, Luo S, Zhang Y, Jia G, Zhang J. The Germinomas arising from the basal ganglia and thalamus. Childs Nervous System. 2008;24:303-306.
Kawabata Y., Takahashi J.A., Arakawa Y., Shirahata M., Hashimoto N. Long-term outcomes in patients within intracranial germinomas: a single institution experience of irradiation with or without chemotherapy. J of Neurooncology. 2008;88:161-167. doi: 10.1007/s11060-008-9542-4
Tsuchida Y, Tsuboi K, Yanaka K, Nose T. Basal ganglia germinoma with crossed cerebellar diaschisis - case report. Neurologia Medica-chirurgica. (Tokyo). 1993;33:779-782.
Nagata K, Nikaido Y, Yuasa T, Fujimoto K, Kim YJ, Inoue M. Germinoma causing wallerian degeneration. Case report and review of the literature. Journal of Neurosurgery. 1998;88:126-128.
Sano K. Pathogenesis of intracranial germ cell tumors reconsidered. J of Neurosurgery. 1999;90:258-264.
Lee J, Lee BL, Yoo KH, Sung KW, Koo HH, Lee SJ, Choi JY, Lee KH, Lee JI, Shin HJ, Kim JH, Suh YL, Lee KH, Lee M. Atypical basal ganglia germinoma presenting as cerebral hemiatrophy: diagnosis and follow-up with(11)C-methionine positron emission tomography. Childs Nervous System. 2009;25:29-37. doi: 10.1007/s00381-008-0674-9
Sudo A, Shiga T, Okajima M, Takano K, Terae S, Sawamura Y, Ohnishi A, Nagashima K, Saitoh S. High uptake on 11C-methionine positron emission tomographic scan of basal ganglia germinoma with cerebral Hemiatrophy. AJNR American J of Neuroradiology. 2003;24:1909-1911.
Haddock MG, Schild SE, Scheithauer BW, Schomberg PJ. Radiation therapy for histologically confirmed primary central nervous system germinoma. International J of Radiation Oncology Biology Physics. 1997;38:915-923.
Nakamura H, Takeshima H, Makino K, Kochi M, Ushio Y, Kuratsu J. Recurrent intracranial germinoma outside the initial radiation field: a single-institution study. Acta Oncology. 2006;45:476-483.