Clinical and prognostic significance of genetic markers in craniocerebral injury (Part III)

Aleksandrova E.V.; Iusupova M.M.; Tenedieva V.D.; Sychev A.A.; Nosikov V.V.; Potapov A.A.

doi:https://doi.org/

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Abstract:

It is now becoming increasingly clear that the course and outcome of craniocerebral injury (CCI) are determined not only by its biomechanism, severity, patient's age, presence of premorbid factors, etc., but also by individual features of the genome of each patient, which puts traumatic brain injury among multifactorial diseases. The genome determines the presence or absence of "genetic predilection" to the development of various complications and sequelae of CCI, which generally determines the progression of traumatic brain injury disease. The first part of the review by Potapov et al. (2010) [2] was devoted to the role of apolipoprotein E (apoE) gene polymorphism in CCI, the second one [3] - to the role of inflammation and immune response genes in the course and outcome of CCI. The present (third) part will provide a review of modern data on the effect of genes underlying intracellular processes of oxidative stress, apoptosis, regeneration, and synthesis of neurotransmitters and their receptors.

Keywords:

gene polymorphism

craniocerebral injury

Authors:

Aleksandrova E.V.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Iusupova M.M.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN

Tenedieva V.D.

NII neĭrokhirurgii im. N.N. Burdenko RAMN, Moskva

Sychev A.A.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

SPIN RSCI: 1171-7690
Scopus AuthorID: 36997601100
ORCID: 0000-0002-0038-1005

Nosikov V.V.

Institut biokhimicheskoĭ fiziki im. N.M. Émanuélia RAN

Potapov A.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

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