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Aleksandrova E.V.
NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva
Iusupova M.M.
FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN
Tenedieva V.D.
NII neĭrokhirurgii im. N.N. Burdenko RAMN, Moskva
Sychev A.A.
FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva
Nosikov V.V.
Institut biokhimicheskoĭ fiziki im. N.M. Émanuélia RAN
Potapov A.A.
NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva
Clinical and prognostic significance of genetic markers in craniocerebral injury (Part III)
Journal: Burdenko's Journal of Neurosurgery. 2014;78(3): 53‑61
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To cite this article:
Aleksandrova EV, Iusupova MM, Tenedieva VD, Sychev AA, Nosikov VV, Potapov AA. Clinical and prognostic significance of genetic markers in craniocerebral injury (Part III). Burdenko's Journal of Neurosurgery. 2014;78(3):53‑61. (In Russ., In Engl.)
It is now becoming increasingly clear that the course and outcome of craniocerebral injury (CCI) are determined not only by its biomechanism, severity, patient's age, presence of premorbid factors, etc., but also by individual features of the genome of each patient, which puts traumatic brain injury among multifactorial diseases. The genome determines the presence or absence of "genetic predilection" to the development of various complications and sequelae of CCI, which generally determines the progression of traumatic brain injury disease. The first part of the review by Potapov et al. (2010) [2] was devoted to the role of apolipoprotein E (apoE) gene polymorphism in CCI, the second one [3] - to the role of inflammation and immune response genes in the course and outcome of CCI. The present (third) part will provide a review of modern data on the effect of genes underlying intracellular processes of oxidative stress, apoptosis, regeneration, and synthesis of neurotransmitters and their receptors.
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Aleksandrova E.V.
NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva
Iusupova M.M.
FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN
Tenedieva V.D.
NII neĭrokhirurgii im. N.N. Burdenko RAMN, Moskva
Sychev A.A.
FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva
Nosikov V.V.
Institut biokhimicheskoĭ fiziki im. N.M. Émanuélia RAN
Potapov A.A.
NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva
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