The effect of Cerebrolysin on the development of skills in patients after acute cerebrovascular accidents

Shmonin A.A.; Kashaev I.Kh.; Luchinin E.A.; Bakulin G.S.

doi:https://doi.org/10.17116/jnevro202612602132

Shmonin A.A.

Academian I.P. Pavlov First Saint Petersburg State Medical University;
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology

ResearcherID: B-3619-2017
ORCID: 0000-0003-2232-4332

Kashaev I.Kh.

V.I. Razumovsky Saratov State Medical University

ORCID: 0009-0004-5814-3116

Luchinin E.A.

V.I. Razumovsky Saratov State Medical University

ORCID: 0000-0001-6304-4594

Bakulin G.S.

V.I. Razumovsky Saratov State Medical University

ORCID: 0009-0007-3849-9301

The effect of Cerebrolysin on the development of skills in patients after acute cerebrovascular accidents

Authors:

Shmonin A.A., Kashaev I.Kh., Luchinin E.A., Bakulin G.S.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2026;125(2): 32‑38

DOI: 10.17116/jnevro202612602132

Read: 398 times

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To cite this article:

Shmonin AA, Kashaev IKh, Luchinin EA, Bakulin GS. The effect of Cerebrolysin on the development of skills in patients after acute cerebrovascular accidents. S.S. Korsakov Journal of Neurology and Psychiatry. 2026;125(2):32‑38. (In Russ.)
https://doi.org/10.17116/jnevro202612602132

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

OBJECTIVE

To evaluate the effect of Cerebrolysin on improving the process of skill formation in patients with acute cerebrovascular accident during medical rehabilitation, based on a systematic review of the literature using elements of meta-analysis.

MATERIAL AND METHODS

A search of publications was conducted using the keywords «Cerebrolysin; Rehabilitation; Arm; Speech; Occupational therapy; Physical therapy; Ergotherapy» in the PubMed, Google Scholar and Elibrary databases. Original comparative studies investigating the effects of the drug on the human population after acute cerebrovascular accident, using rehabilitation measures and measuring the effectiveness using BI, ARAT, FIM, mRS, RMI, COPM, WAB and FMA were included. Mathematical processing of the arm action test (ARAT) results was performed using the SMD method.

RESULTS

The positive effect of potentiating neuroplasticity with Cerebrolysin consists in a significant improvement in daily activity in patients undergoing early comprehensive rehabilitation or physical therapy after a stroke. Patients statistically significantly restore the functionality of the affected upper limb during long-term rehabilitation initiated in the early subacute period. Improvement in speech and social activity is noted due to speech therapy interventions. A decrease in the level of depression and improvement in social adaptation have been proven during occupational therapy and psychological rehabilitation. The best results are observed with the introduction of the drug at a dosage of 30 ml. against the background of comprehensive multidisciplinary rehabilitation. Efficiency decreases with late onset of rehabilitation and a short course of drug administration.

CONCLUSION

The use of Cerebrolysin in a dose of 10 ml to 30 ml during post-stroke rehabilitation leads to an increase in the quantity and quality of restored functions and formed skills, which was shown in a small group of 10 studies.

Keywords:

rehabilitation

Cerebrolysin

neuroplasticity

skills

stroke

Authors:

Shmonin A.A.

Academian I.P. Pavlov First Saint Petersburg State Medical University;
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology

ResearcherID: B-3619-2017
ORCID: 0000-0003-2232-4332

Kashaev I.Kh.

V.I. Razumovsky Saratov State Medical University

ORCID: 0009-0004-5814-3116

Luchinin E.A.

V.I. Razumovsky Saratov State Medical University

ORCID: 0000-0001-6304-4594

Bakulin G.S.

V.I. Razumovsky Saratov State Medical University

ORCID: 0009-0007-3849-9301

Received:

26.11.2025

Accepted:

04.02.2026

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References:

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