Headache and cognitive impairment in patients with chronic cerebral ischemia

Vershuta V.A.; Voskresenskaya O.N.; Tabeeva G.R.

doi:https://doi.org/10.17116/jnevro202512512178

Vershuta V.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0001-6342-5450

Voskresenskaya O.N.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0002-7330-633X

Tabeeva G.R.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0002-3833-532X

Headache and cognitive impairment in patients with chronic cerebral ischemia

Authors:

Vershuta V.A., Voskresenskaya O.N., Tabeeva G.R.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(12): 78‑81

DOI: 10.17116/jnevro202512512178

Read: 535 times

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To cite this article:

Vershuta VA, Voskresenskaya ON, Tabeeva GR. Headache and cognitive impairment in patients with chronic cerebral ischemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(12):78‑81. (In Russ.)
https://doi.org/10.17116/jnevro202512512178

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

OBJECTIVE

Analysis of the relationship between cognitive impairment (CI) and headache (HA) in patients with chronic cerebral ischemia (CCI).

MATERIAL AND METHODS

The study included 97 patients aged 50 to 85 years (65 females, 32 males) diagnosed with CCI. The test group consisted of 64 patients with HA, and the comparison group included 33 patients without HA. The presence and severity of CI were determined by the Montreal Cognitive Assessment (MoCA) Score, and the brain white matter hyperintensity (WMHI) was determined by MRI according to the Fazekas scale.

RESULTS

Based on the HA diagnostic criteria of the International Classification of Headache Disorders, 3rd edition, primary forms of HA were diagnosed in 48 (75%) patients, tension headache (THA) prevailed (43.8%), migraine was diagnosed in 23.4%, and combined THA and migraine in 7.8%; secondary HA was detected in 16 (25%) patients. Moderate CI was more common in patients with CCI and HA than those without HA (48 vs. 18 subjects, respectively, p=0.041). In the test group, the mean MoCA total score was 19 [17, 24] vs. 23 [20, 26] in the comparison group (p=0.0001). Statistically significant differences were found when comparing the Fazekas score in WMHI groups (p=0.038).

CONCLUSION

HA can be a risk factor for CCI progression and should be considered when developing therapeutic strategies.

Keywords:

headache

chronic cerebral ischemia

cognitive impairment

white matter hyperintensity

Authors:

Vershuta V.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0001-6342-5450

Voskresenskaya O.N.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0002-7330-633X

Tabeeva G.R.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0002-3833-532X

Received:

19.08.2025

Accepted:

21.09.2025

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References:

Tabeeva GR, Kalimeeva EY, Koberskaya NN, et al. Possibilities of therapy for early manifestations of chronic cerebral ischemia: results of the PROFILE program. Nevrologiya, neiropsikhiatriya, psikhosomatika. 2017;9(3):36-41. (In Russ.). https://doi.org/10.14412/2074-2711-2017-3-36-41
Platov MP, Kosivtsova OV. Headache in elderly patients with chronic cerebral ischemia: outpatient diagnosis and treatment. Nevrologiya, neiropsikhiatriya, psikhosomatika. 2018;10(1):102-106. (In Russ.). https://doi.org/10.14412/2074-2711-2018-1-102-106
Zakharov VV, Sleptsova KB, Martynova OO. Chronic cerebral ischemia: a view from the XXI century. RMJ. 2021;5:45-49. (In Russ.).
Voskresenskaya ON, Zakharova NB, Tarasova YS, et al. Possible mechanisms of cognitive dysfunction in patients with chronic forms of cerebrovascular diseases. Nevrologiya, neiropsikhiatriya. 2018;10(1):32-36. (In Russ.). https://doi.org/10.14412/2074-2711-2018-1-32-36
Kulesh AA, Drobakha VE, Shestakov VV. Cerebral small vessel disease: classification, clinical manifestations, diagnosis, and features of treatment. Nevrologiya, neiropsikhiatriya, psikhosomatika. 2019;11(Suppl. 3):4-17. (In Russ.). https://doi.org/10.14412/2074-2711-2019-3S-4-17
Gusev EI, Chukanova AS. Modern pathogenetic aspects of development of cerebral chronic ischemia. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2015;115(3):4-8. (In Russ.). https://doi.org/10.17116/jnevro2015115314-8
Rundek T, Tolea M, Ariko T, et al. Vascular Cognitive Impairment (VCI). Neurotherapeutics. 2022 Jan;19(1):68-88. https://doi.org/10.1007/s13311-021-01170-y
Iadecola C, Duering M, Hachinski V, et al. Vascular Cognitive Impairment and Dementia: JACC Scientific Expert Panel. J Am Coll Cardiol. 2019;73(25):3326-3344. https://doi.org/10.1016/j.jacc.2019.04.034
Grishina DA, Lokshina AB. Issues of diagnosis and treatment of mild cognitive impairment. Meditsinskiy Sovet. 2022;16(21):46-53. (In Russ.). https://doi.org/10.21518/2079-701X-2022-16-21-46-53
Magalhães JE, Sampaio Rocha-Filho PA. Migraine and cerebrovascular diseases: Epidemiology, pathophysiological, and clinical considerations. Headache. 2018;58(8):1277-1286. https://doi.org/10.1111/head.13378
Kulesh AA, Emelin AYu, Bogolepova AN, et al. Clinical manifestations and issues of diagnosis of chronic cerebrovascular disease (chronic cerebral ischemia) at an early (pre-dementia) stage. Nevrologiya, neiropsikhiatriya, psikhosomatika. 2021;13(1):4-12. (In Russ.). https://doi.org/10.14412/2074-2711-2021-1-4-12
Chen SP, Eikermann-Haerter K. How Imaging Can Help Us Better Understand the Migraine-Stroke Connection. Headache. 2020;60(1):217-228. https://doi.org/10.1111/head.13664
Ashina S, Bentivegna E, Martelletti P, et al. Structural and Functional Brain Changes in Migraine. Pain Ther. 2021;10(1):211-223. https://doi.org/10.1007/s40122-021-00240-5
George KM, Folsom AR, Sharrett AR, et al. Migraine Headache and Risk of Dementia in the Atherosclerosis Risk in Communities Neurocognitive Study. Headache. 2020;60(5):946-953. https://doi.org/10.1111/head.13794
Wang L, Wu JC, Wang FY, et al. Meta-analysis of association between migraine and risk of dementia. Acta Neurol Scand. 2022;145(1):87-93. https://doi.org/10.1111/ane.13528
Honningsvåg LM, Hagen K, Håberg A, et al. Intracranial abnormalities and headache: A population-based imaging study (HUNT MRI). Cephalalgia. 2016;36(2):113-121. https://doi.org/10.1177/0333102415583147
Honningsvåg LM, Håberg AK, Hagen K, et al. White matter hyperintensities and headache: A population-based imaging study (HUNT MRI). Cephalalgia. 2018;38(13):1927-1939. https://doi.org/10.1177/0333102418764891
Hagen K, Stordal E, Linde M, et al. Headache as a risk factor for dementia: a prospective population-based study. Cephalalgia. 2014;34(5):327-335. https://doi.org/10.1177/0333102413513181
Yang FC, Lin TY, Chen HJ, et al. Increased Risk of Dementia in Patients with Tension-Type Headache: A Nationwide Retrospective Population-Based Cohort Study. PLoS One. 2016;11(6):e0156097. https://doi.org/10.1371/journal.pone.0156097
Kim SJ, Park SM, Cho HJ, et al. Primary headaches increase the risk of dementias: An 8-year nationwide cohort study. PLoS One. 2022;17(8):e0273220. https://doi.org/10.1371/journal.pone.0273220
Wang R, Laveskog A, Laukka EJ, et al. MRI load of cerebral microvascular lesions and neurodegeneration, cognitive decline, and dementia. Neurology. 2018;91(16):e1487-e1497. https://doi.org/10.1212/WNL.0000000000006355