The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Chutko L.S.

N. Bekhtereva Institute of Human Brain Russian Academy of Sciences

Surushkina S.Yu.

N. Bekhtereva Institute of Human Brain Russian Academy of Sciences

Yakovenko E.A.

N. Bekhtereva Institute of Human Brain Russian Academy of Sciences

Cherednichenko D.V.

N. Bekhtereva Institute of Human Brain Russian Academy of Sciences

Chronic fatigue syndrome in children

Authors:

Chutko L.S., Surushkina S.Yu., Yakovenko E.A., Cherednichenko D.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(9): 28‑33

DOI: 10.17116/jnevro202412409128

Read: 1662 times

Download PDF (RU)
Contact the author
Table of contents

CHRONIC FATIGUE SYNDROME IN CHILDREN
CHRONIC FATIGUE SYNDROME IN CHILDREN

To cite this article:

Chutko LS, Surushkina SYu, Yakovenko EA, Cherednichenko DV. Chronic fatigue syndrome in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(9):28‑33. (In Russ.)
https://doi.org/10.17116/jnevro202412409128

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Factors affe­cting the quality of life of patients with neurological mani­festations of post-COVID syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(9):44-50
Asso­ciation of inflammation and chro­nic fati­gue syndrome in patients with Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(9):79-87
The technology of indu­ction of physiological keto­sis in asthenia of various origins and decreased resi­stance to cognitive and physical acti­vity. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):48-54
Effi­cacy and safety of fonturacetam in asthenia: a systematic review and meta-analysis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(2):69-79
Asthenia in the acute period of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3-2):5-10
Cognitive impairment in asthenic diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):27-32
Modern approaches to diagnosis and treatment of postinfectious asthenic syndrome in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4):42-52
Possibilities of using meldonium as part of complex therapy in patients with ischemic heart disease and chro­nic heart failure combined with obesity. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(1):53-60
Abstract:

The article provides an overview of scientific publications devoted to the study of chronic fatigue syndrome (CFS). The results of works devoted to the study of the epidemiology of this pathology in childhood and adults are considered. The authors presented different views on the etiology and basic mechanisms of the pathogenesis of CFS, current diagnostic criteria for this disease and features of clinical manifestations in childhood. Special attention is paid to the description of the main neurocognitive deficits observed in CFS in children. Also reviewed are studies aimed at finding effective approaches to the treatment of CFS in children.

Keywords:

chronic fatigue syndrome
asthenia
Cogitum

Authors:

Chutko L.S.

N. Bekhtereva Institute of Human Brain Russian Academy of Sciences

Surushkina S.Yu.

N. Bekhtereva Institute of Human Brain Russian Academy of Sciences

Yakovenko E.A.

N. Bekhtereva Institute of Human Brain Russian Academy of Sciences

Cherednichenko D.V.

N. Bekhtereva Institute of Human Brain Russian Academy of Sciences

Received:

22.08.2024

Accepted:

23.08.2024

Close metadata

References:

  1. Putilina MV. Asthenic disorders as a manifestation of chronic fatigue syndrome. S.S. Korsakov Journal of Neurologyand Psychiatry. 2021;121(8):125-130. (In Russ.). https://doi.org/10.17116/jnevro2021121081125
  2. Nacul L, Authier FJ, Scheibenbogen C, et al. European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE): Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe. Medicina (Kaunas). 2021;57(5):510.  https://doi.org/10.3390/medicina57050510
  3. Grach SL, Seltzer J, Chon TY, Ganesh R. Diagnosis and Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Mayo Clin Proc. 2023;98(10):1544-1551. https://doi.org/10.1016/j.mayocp.2023.07.032
  4. Słomko J, Newton JL, Kujawski S. Prevalence and characteristics of chronic fatigue syndrome/ myalgic encephalomyelitis (CFS/ME) in Poland: a crosssectional study. BMJ Open 2019;9:e023955. https://doi.org/10.1136/bmjopen-2018-023955
  5. Lim E-J, Ahn Y-C, Jang E-S, et al. Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). J Transl Med. 2020;18:100. 
  6. Orji N, Campbell JA, Wills K, et al. Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in Australian primary care patients: only part of the story? BMC Public Health. 2022;22(1):1516. https://doi.org/10.1186/s12889-022-13929-9
  7. Fukuda K, Straus SE, Hickie I. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med. 1994;121(12):953-959.  Https://doi.org/10.7326/0003-4819-121-12-199412150-00009
  8. Bested AC, Marshall LM. Review of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An evidence-based approach to diagnosis and management by clinicians. Rev Environ Health. 2015;30:223-249. 
  9. Nijhof SL, Maijer K, Bleijenberg G, et al. Adolescent chronic fatigue syndrome: prevalence, incidence, and morbidity. Pediatrics. 2011;127(5):e1169-1175. https://doi.org/10.1542/peds.2010-1147
  10. Crawley E. The epidemiology of chronic fatigue syndrome/myalgic encephalitis in children. Arch Dis Child. 2014;99(2):171-174.  https://doi.org/10.1136/archdischild-2012-302156
  11. Knight S, Elders S, Rodda J, et al. Epidemiology of paediatric chronic fatigue syndrome in Australia. Arch Dis Child. 2019;104(8):733-738.  https://doi.org/10.1136/archdischild-2018-316450
  12. Collin SM, Norris T, Nuevo R. Chronic fatigue syndrome at Age 16 Years. Pediatrics. 2016;137(2):e20153434. https://doi.org/10.1542/peds.2015-3434
  13. Crawley E, Emond AM, Sterne JA. Unidentified Chronic Fatigue Syndrome/myalgic encephalomyelitis (CFS/ME) is a major cause of school absence: surveillance outcomes from school-based clinics. BMJ Open. 2011;1(2):e000252. https://doi.org/10.1136/bmjopen-2011-000252
  14. Missen A, Hollingworth W, Eaton N, Crawley E. The financial and psychological impacts on mothers of children with chronic fatigue syndrome (CFS/ME). Child Care Health Dev. 2012;38(4):505-512.  https://doi.org/10.1111/j.1365-2214.2011.01298.x
  15. Huth TK, Eaton-Fitch N, Staines D, Marshall-Gradisnik S. A systematic review of metabolomic dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID). J Transl Med. 2020;18(1):198.  https://doi.org/10.1186/s12967-020-02356-2
  16. Glassford JA. The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Front Physiol. 2017;8:88. 
  17. Nikitina AJ, Levin OS. Chronic fatigue syndrome against the background of the COVID-19 pandemic. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(10-2):92-98. (In Russ.). https://doi.org/10.17116/jnevro202112110292
  18. Sapra A, Bhandari P. Chronic Fatigue Syndrome. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024;32491608.
  19. Deumer US, Varesi A, Floris V, et al. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview. J Clin Med. 2021;10(20):4786. https://doi.org/10.3390/jcm10204786
  20. Mandarano AH, Maya J, Giloteaux L, et al. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients Exhibit Altered T Cell Metabolism and Cytokine Associations. J Clin Investig. 2020;130:1491-1505. https://doi.org/10.1172/JCI132185
  21. Overholser JC, Beale EE. Neurasthenia: Modern Malady or Historical Relic? J Nerv Ment Dis. 2019;207(9):731-739.  https://doi.org/10.1097/NMD.0000000000000943
  22. Loades M, Brigden A, Crawley E. Current treatment approaches for paediatric CFS/ME. Paediatr Child Health (Oxford). 2017;27(9):432-434.  https://doi.org/10.1016/j.paed.2017.05.007
  23. Sotzny F, Blanco J, Capelli E, et al. European Network on ME/CFS (EUROMENE). Myalgic Encephalomyelitis/Chronic Fatigue Syndrome — Evidence for an autoimmune disease. Autoimmun Rev. 2018;17(6):601-609.  https://doi.org/10.1016/j.autrev.2018.01.009
  24. Collin SM, Nuevo R, van de Putte EM. Chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME) is different in children compared to in adults: A study of UK and Dutch clinical cohorts. BMJ Open. 2015;5(10):e008830. https://doi.org/10.1136/bmjopen-2015-008830
  25. Solomon-Moore E, Jago R, Beasant L, et al. Physical activity patterns among children and adolescents with mild-to-moderate chronic fatigue syndrome/myalgic encephalomyelitis. BMJ Paediatrics Open. 2019;3(1):e000425. https://doi.org/10.1136/bmjpo-2018-000425
  26. Norris T, Hawton K, Hamilton-Shield J, Crawley E. Obesity in adolescents with chronic fatigue syndrome: an observational study. Arch Dis Child. 2017;102(1):35-39.  https://doi.org/10.1136/archdischild-2016-311293
  27. Collin SM, Norris T, Gringras P, et al. Childhood sleep and adolescent chronic fatigue syndrome (CFS/ME): evidence of associations in a UK birth cohort. Sleep Med. 2018;46:26-36.  https://doi.org/10.1016/j.sleep.2018.01.005
  28. Winger A, Kvarstein G, Wyller VB, et al. Health related quality of life in adolescents with chronic fatigue syndrome: a cross-sectional study. Health Qual Life Outcomes. 2015;13:96.  https://doi.org/10.1186/s12955-015-0288-3
  29. Loades ME, Stallard P, Morris R, et al. Do adolescents with chronic fatigue syndrome (CFS/ME) and co-morbid anxiety and/or depressive symptoms think differently to those who do not have co-morbid psychopathology? J Affect Disord. 2020 Sep 1;274:752-758.  https://doi.org/10.1016/j.jad.2020.05.113
  30. Miike T, Tomoda A, Jhodoi T, et al. Learning and memorization impairment in childhood chronic fatigue syndrome manifesting as school phobia in Japan. Brain Develop. 2004; 26(7):442-447.  https://doi.org/10.1016/j.braindev.2003.10.004
  31. Mizuno K, Watanabe Y. Neurocognitive impairment in childhood chronic fatigue syndrome. Front Physiol. 2013;4:87.  https://doi.org/10.3389/fphys.2013.00087
  32. Sáez Francàs N, Alegre J, Calvo Piñero N. Prevalence of ADHD in chronic fatigue syndrome. Eur Psychiatry. 2011;26(S2):1574-1574. https://doi.org/10.1016/S0924-9338(11)73278-3
  33. Cockshell SJ, Mathias JL. Cognitive deficits in chronic fatigue syndrome and their relationship to psychological status, symptomatology, and everyday functioning. Neuropsychology. 2013;27(2):230-242.  https://doi.org/10.1037/a0032084
  34. Haig-Ferguson A, Tucker P, Eaton N, Hunt L, Crawley E. Memory and attention problems in children with chronic fatigue syndrome or myalgic encephalopathy. Arch Dis Child. 2009;94(10):757-762.  https://doi.org/10.1136/adc.2008.143032
  35. Kawatani J, Mizuno K, Shiraishi S. Cognitive dysfunction and mental fatigue in childhood chronic fatigue syndrome--a 6-month follow-up study. Brain Dev. 2011;33(10):832-841.  https://doi.org/10.1016/j.braindev.2010.12.009
  36. Mizuno K, Tanaka M, Tanabe H, et al. Less efficient and costly processes of frontal cortex in childhood chronic fatigue syndrome. Neuroimage Clin. 2015;9:355-368.  https://doi.org/10.1016/j.nicl.2015.09.001
  37. Parslow RM, Anderson N, Byrne D, et al. Adolescent’s descriptions of fatigue, fluctuation and payback in chronic fatigue syndrome/myalgic encephalopathy (CFS/ME): Interviews with adolescents and parents. BMJ Paediatrics Open. 2018;2(1):e000281 
  38. Josev EK, Jackson ML, Bei B, et al. Sleep quality in adolescents with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). J Clinl Sleep Med. 2017;13(9):1057-1066.
  39. Pedersen M, Ekstedt M, Småstuen M, et al. A wake rhythm disturbances and perceived sleep in adolescent chronic fatigue syndrome. J Sleep Res. 2017;26(5):595-601. 
  40. Loades ME Rimes KA, Chalder T. Sleep problems in adolescents with CFS: A case-control study nested within a prospective clinical cohort. Clin Child Psychol Psychiatry. 2020;25(4):816-832.  https://doi.org/10.1177/1359104520918364
  41. Smith MS, Buchwald DS, Bogart A. Adolescent offspring of mothers with chronic fatigue syndrome. J Adolesc Health 2010;46:284-291.  https://doi.org/10.1016/j.jadohealth.2009.08.001
  42. van de Putte EM, van Doornen LJ, Engelbert R, et al. Mirrored symptoms in mother and child with chronic fatigue syndrome. Pediatrics. 2006;117(6):2074-2079. https://doi.org/10.1542/peds.2005-2307
  43. Loades ME, Rimes KA, Ali S. Does fatigue and distress in a clinical cohort of adolescents with chronic fatigue syndrome correlate with fatigue and distress in their parents? Child Care Health Dev. 2019;45(1):129-137.  https://doi.org/10.1111/cch.12626
  44. Rangel L, Garralda ME, Jeffs J, Rose G. Family health and characteristics in chronic fatigue syndrome, juvenile rheumatoid arthritis, and emotional disorders of childhood. J Am Acad Child Adol Psychiatry. 2005;44(2):150-158.  https://doi.org/10.1097/00004583-200502000-00007
  45. Knoop H, Stulemeijer M, de Jong LW, et al. Efficacy of cognitive behavioral therapy for adolescents with chronic fatigue syndrome: long-term follow-up of a randomized, controlled trial. Pediatrics. 2008;121(3):e619-625.  https://doi.org/10.1542/peds.2007-1488
  46. Chalder T, Deary V, Husain K, Walwyn R. Family-focused cognitive behaviour therapy versus psycho-education for chronic fatigue syndrome in 11- to 18-year-olds: A randomized controlled treatment trial. Psychol Med. 2010;40(8):1269-1279.
  47. Stoll S, Crawley E, Richards V, et al. What treatments work for anxiety in children with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)? Systematic review. BMJ Open. 2017;7(9):e015481. https://doi.org/10.1136/bmjopen-2016-015481
  48. Vink M, Vink-Niese A. The Draft Report by the Institute for Quality and Efficiency in Healthcare Does Not Provide Any Evidence That Graded Exercise Therapy and Cognitive Behavioral Therapy Are Safe and Effective Treatments for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Diseases. 2023;11(1):11.  https://doi.org/10.3390/diseases11010011
  49. Gaunt DM, Brigden A, Harris S, et al. Graded exercise therapy compared to activity management for paediatric chronic fatigue syndrome/myalgic encephalomyelitis: pragmatic randomized controlled trial. Eur J Pediatr. 2024;183(5):2343-2351. https://doi.org/10.1007/s00431-024-05458-x
  50. Shchederkina IO, Ovsyannikov DYu, Glazyrina AA. Asthenic syndrome in children and adolescents: choice of therapy. Nervnye Bolezni. 2021;2:34-39. (In Russ). https://doi.org/10.24412/2226-0757-2021-12322
  51. Nemkova SA. Modern possibilities of using N-acetylaspartate (the drug Cogitum) in the treatment of asthenic syndrome in children. Nervnye Bolezni. 2023;3:82-89. (In Russ.). https://doi.org/10.24412/2226-0757-2023-13011
  52. Esin RG, Khayrullin IKh, Esin OR, et al. Efficacy of potassium N-acetylaminosuccinate (Cogitum) in the treatment of asthenic syndrome: results of double-blind placebo-controlled trial. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(6):52-56. (In Russ.). https://doi.org/10.17116/jnevro202312306152
  53. Shishkova VN, Dranitsina BG. Postcovid cognitive impairment. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(12):45-49. (In Russ.). https://doi.org/10.17116/jnevro202212212145
  54. Milovanova OA, Astanina SYu. Treatment of asthenoneurotic disorders in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(12):112-113. (In Russ.). https://doi.org/10.17116/jnevro2016116121112-113
  55. Goryunova AV, Shevchenko YuS, Goryunov AV. Cogitum in children’s neurology and psychiatry (experience in the practical use). S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(7-2):58-66. (In Russ.). https://doi.org/10.17116/jnevro201911907258
  56. Bobylova MYu. Utility of Cogitum in children with attention deficit hyperactivity disorder and subclinical epileptiform activity on the electroencephalogram. Russkiy Zhurnal Detskoy Nevrologii. 2022;17(4):54-62. (In Russ.). https://doi.org/10.17650/2073-8803-2022-17-4-54-62
  57. Chutko LS, Surushkina SYu, Yakovenko EA, et al. Cognitive impairment in children with organic asthenic disorder. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(9-2):92-99. (In Russ.). https://doi.org/10.17116/jnevro202312309292
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.