Electroencephalographic differences in patients with paranoid schizophrenia with or without a history of suicide attempts

Galkin S.A.; Kornetova E.G.; Azarenko N.N.; Oshkina T.A.; Kornetov A.N.; Bokhan N.A.

doi:https://doi.org/10.17116/jnevro2024124051113

Galkin S.A.

Mental Health Research Institute — Tomsk National Research Medical Center Russian Academy of Science

ORCID: 0000-0002-7709-3917

Kornetova E.G.

Mental Health Research Institute — Tomsk National Research Medical Center Russian Academy of Science

ORCID: 0000-0002-5179-9727

Azarenko N.N.

Mental Health Research Institute — Tomsk National Research Medical Center Russian Academy of Science;
Siberian State Medical University

Oshkina T.A.

Mental Health Research Institute — Tomsk National Research Medical Center Russian Academy of Science

ORCID: 0000-0003-0927-0050

Kornetov A.N.

Mental Health Research Institute — Tomsk National Research Medical Center Russian Academy of Science;
Siberian State Medical University

ORCID: 0000-0002-2342-7504

Bokhan N.A.

Mental Health Research Institute — Tomsk National Research Medical Center Russian Academy of Science;
Siberian State Medical University

ORCID: 0000-0002-1052-855X

Electroencephalographic differences in patients with paranoid schizophrenia with or without a history of suicide attempts

Authors:

Galkin S.A., Kornetova E.G., Azarenko N.N., Oshkina T.A., Kornetov A.N., Bokhan N.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(5): 113‑119

DOI: 10.17116/jnevro2024124051113

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To cite this article:

Galkin SA, Kornetova EG, Azarenko NN, Oshkina TA, Kornetov AN, Bokhan NA. Electroencephalographic differences in patients with paranoid schizophrenia with or without a history of suicide attempts. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(5):113‑119. (In Russ.)
https://doi.org/10.17116/jnevro2024124051113

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To identify differences in electroencephalographic parameters in schizophrenia patients with and without a history of suicide attempts.

MATERIAL AND METHODS

Eighty-seven inpatients (50 men and 37 women) with paranoid schizophrenia were examined. Suicidal attempts in the anamnesis of patients were verified by a psychiatrist on the basis of clinical interviewing. The severity of psychopathological symptoms was assessed using The Positive and Negative Syndrome Scale (PANSS) based on a five-factor model. Electroencephalogram (EEG) parameters were recorded and evaluated using a 16-channel encephalograph. A clinical and quantitative analysis of the recordings was carried out with the calculation of absolute spectral power indicators for theta, alpha and beta rhythms, as well as the severity of the activation reaction (Berger effect).

RESULTS

Significantly higher rates of the PANSS depression factor were revealed in patients with a history of suicide attempts (p=0.016). Clinical analysis of EEG changes did not reveal any significant differences between the groups (p>0.05). The spectral analysis of the EEG showed significant differences only in the spectral power of the beta rhythm in the central (p=0.048) and occipital (p=0.021) leads with closed eyes, which was lower in the group with a history of suicide attempts. The degree of alpha rhythm depression in the occipital leads was also significantly lower in this group (p=0.016). The regression analysis showed that significant correlates of suicidal attempts in patients with paranoid schizophrenia are the PANSS depressive factor (t=2.784; p=0.016) and a deficiency in the activation response to EEG (t=–2.035; p=0.045).

CONCLUSION

The results complement previous studies on the relationship between suicidal attempts, clinical symptoms and neurophysiological features of the functioning of the brain of patients with paranoid schizophrenia.

Keywords:

paranoid schizophrenia

suicidal attempts

electroencephalography

beta rhythm

Berger effect

Authors:

Galkin S.A.

Mental Health Research Institute — Tomsk National Research Medical Center Russian Academy of Science

ORCID: 0000-0002-7709-3917

Kornetova E.G.

Mental Health Research Institute — Tomsk National Research Medical Center Russian Academy of Science

ORCID: 0000-0002-5179-9727

Azarenko N.N.

Mental Health Research Institute — Tomsk National Research Medical Center Russian Academy of Science;
Siberian State Medical University

Oshkina T.A.

Mental Health Research Institute — Tomsk National Research Medical Center Russian Academy of Science

ORCID: 0000-0003-0927-0050

Kornetov A.N.

Mental Health Research Institute — Tomsk National Research Medical Center Russian Academy of Science;
Siberian State Medical University

ORCID: 0000-0002-2342-7504

Bokhan N.A.

Mental Health Research Institute — Tomsk National Research Medical Center Russian Academy of Science;
Siberian State Medical University

ORCID: 0000-0002-1052-855X

Received:

25.11.2023

Accepted:

17.01.2024

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