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Davydova Yu.D.

Institute of Biochemistry and Genetics — Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences;
Ufa University of Science and Technology

Kazantseva A.V.

Institute of Biochemistry and Genetics — Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences;
Ufa State Petroleum Technical University

Khusnutdinova E.K.

Institute of Biochemistry and Genetics — Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences;
Ufa University of Science and Technology

A perspective on the application of CRISPR/CAS9 genome editing system to study of molecular-genetic basis of mental disorders

Authors:

Davydova Yu.D., Kazantseva A.V., Khusnutdinova E.K.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(3): 27‑33

DOI: 10.17116/jnevro202412403127

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Table of contents

A PERSPECTIVE ON THE APPLICATION OF CRISPR/CAS9 GENOME EDITING SYSTEM TO STUDY OF MOLECULAR-GENETIC BASIS OF MENTAL DISORDERS
A PERSPECTIVE ON THE APPLICATION OF CRISPR/CAS9 GENOME EDITING SYSTEM TO STUDY OF MOLECULAR-GENETIC BASIS OF MENTAL DISORDERS

To cite this article:

Davydova YuD, Kazantseva AV, Khusnutdinova EK. A perspective on the application of CRISPR/CAS9 genome editing system to study of molecular-genetic basis of mental disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(3):27‑33. (In Russ.)
https://doi.org/10.17116/jnevro202412403127

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Abstract:

Schizophrenia, depression, bipolar disorder and autism spectrum disorders are common mental disorders that are among the leading causes of disability worldwide. The major complication to effective therapies for mental disorders is the poor understanding of their pathogenic mechanisms. Currently, an increasing number of research groups are focusing on uncovering the molecular mechanisms of mental disorders and developing novel therapies using the CRISPR/Cas9 (Clustered, Regularly Interspaced, Short Palindromic Repeats (CRISPR) — CRISPR-associated system 9 (Cas9)) system to determine the molecular mechanisms of developing mental disorders and novel therapy. The CRISPR/Cas9 system is the most promising among genome editing tools. Numerous advantages of the CRISPR/Cas9 system and its successful application in some studies provide wide opportunities for genome therapy and regeneration medicine. In this review we shortly describe structure and function of the CRISPR/Cas9 system and its application to study the molecular-genetic basis of mental disorders in human.

Keywords:

CRISPR/Cas9
mental disorder
schizophrenia
depression
autism spectrum disorder
bipolar disorder

Authors:

Davydova Yu.D.

Institute of Biochemistry and Genetics — Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences;
Ufa University of Science and Technology

Kazantseva A.V.

Institute of Biochemistry and Genetics — Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences;
Ufa State Petroleum Technical University

Khusnutdinova E.K.

Institute of Biochemistry and Genetics — Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences;
Ufa University of Science and Technology

Received:

14.09.2023

Accepted:

24.11.2023

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