Steadfastly increased level of the ciliary neurotrophic factor in the blood serum within the positive therapeutic dynamics of depression as possible prognostic marker of depressive relapse

Uzbekov M.G.

Serbsky National Medical Research Center of Psychiatry and Narcology — Moscow Research Institute of Psychiatry

ORCID: 0000-0002-1460-9146

Shikhov S.N.

Serbsky National Medical Research Center of Psychiatry and Narcology — Moscow Research Institute of Psychiatry

ORCID: 0000-0003-1246-2029

Kryukov V.V.

Serbsky National Medical Research Center of Psychiatry and Narcology — Moscow Research Institute of Psychiatry

ORCID: 0000-0002-9099-0989

Krasnov V.N.

Serbsky National Medical Research Center of Psychiatry and Narcology — Moscow Research Institute of Psychiatry

ORCID: 0000-0002-5249-3316

Steadfastly increased level of the ciliary neurotrophic factor in the blood serum within the positive therapeutic dynamics of depression as possible prognostic marker of depressive relapse

Authors:

Uzbekov M.G., Shikhov S.N., Kryukov V.V., Krasnov V.N.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(8): 120‑123

DOI: 10.17116/jnevro2023123081120

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To cite this article:

Uzbekov MG, Shikhov SN, Kryukov VV, Krasnov VN. Steadfastly increased level of the ciliary neurotrophic factor in the blood serum within the positive therapeutic dynamics of depression as possible prognostic marker of depressive relapse. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(8):120‑123. (In Russ.)
https://doi.org/10.17116/jnevro2023123081120

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To study a role of the ciliary neurotrophic factor (CNTF) in the pathogenesis of depression and its prognostic significance in dynamics of the antidepressant therapy.

MATERIAL AND METHODS

CNTF level was investigated in the blood serum of patients with melancholic depression (n=32) before the start of therapy and after 30 days, when improvement was achieved by at least 75% of baseline scores on the Hamilton Depression Rating Scale.

RESULTS

Steadfastly increased level of CNTF in the blood serum of patients with melancholic depression compared with the control, remaining practically unchanged with an obvious improvement in the condition — 732.2±126.5 and 679.1±63.1 pg/ml of serum, respectively (p>0.05).

CONCLUSION

The initially elevated level of CNTP indicates its probable significance in the pathogenesis of depression; persistently high serum CNTP level, despite clinical improvement during therapy, can serve as a predictor of the stability of the biological mechanisms of recurrent depressive disorder with a continuing risk of another relapse of a depressive episode.

Keywords:

recurrent depression

ciliary neurotrophic factor

antidepressive therapy

pathogenesis

prognosis

Authors:

Uzbekov M.G.

Serbsky National Medical Research Center of Psychiatry and Narcology — Moscow Research Institute of Psychiatry

ORCID: 0000-0002-1460-9146

Shikhov S.N.

Serbsky National Medical Research Center of Psychiatry and Narcology — Moscow Research Institute of Psychiatry

ORCID: 0000-0003-1246-2029

Kryukov V.V.

Serbsky National Medical Research Center of Psychiatry and Narcology — Moscow Research Institute of Psychiatry

ORCID: 0000-0002-9099-0989

Krasnov V.N.

Serbsky National Medical Research Center of Psychiatry and Narcology — Moscow Research Institute of Psychiatry

ORCID: 0000-0002-5249-3316

Received:

19.04.2023

Accepted:

24.04.2023

List of references:

Wittchen HU, Jacoby F, Rehm J, et al. The size and burden of mental disorders and other disorders of the brain in Europe. European Neuropsychopharmacology. 2011;21:655-679. https://doi.org/10.1016/j.euroneuro.2011.07.018
Patel V, Saxena S, Lund C, et al. The Lancet Comission on global mental health and sustainable development. Lancet Psychiatry. 2018;392:1553-1598. https://doi.org/10.1016/s0140-6736(19)31108-0
Kupfer DJ, Targ E, Stark J. Electroencephalographic sleep in unipolar depressive subtypes: support for biological and familial classification. J Nerv Ment Dis. 1982;189(8):494-498. https://doi.org/10.1097/00005053-198208000-00009
Syreishchikova TI, Smolina NV, Brilliantova VV, Uzbekov MG, Dobretsov GE. Changes in the binding centers of the albumin molecule in melancholic depression in the dynamics of pharmacotherapy: registration using subnanosecond fluorescence spectroscopy. Biofizika. 2017;62(2):364-369. (In Russ.).
Akahori Y, Takamoto N, Masumoto A, et al. Circulating levels of ciliary neurotrophic factor in normal pregnancy and preeclampsia. Acta Med Okayama. 2010;64(2):129-136. https://doi.org/10.18926/AMO/32847
Sendtner M, Carroll P, Holtmann B, et al. Ciliary neurotrophic factor. J Neurobiol. 1994;25(11):1436-1453. https://doi.org/10.1002/neu.480251110
Brondino N, Rocchetti M, Fusar-Poli L, et al. Increased CNTF levels in adults with autism spectrum disorders. World J Biol Psychiatry. 2019;20(9):742-746. https://doi.org/10.1080/15622975.2018.1481999
Peruga I, Hartwig S, Merkler D, et al. Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behavior. Behav Brain Res. 2012;229(2):325-332. https://doi.org/10.1016/j.bbr.2012.01.020
Beurrier C, Faideau M, Bennouar KE, et al. Ciliary neurotrophic factor protects striatal neurons against excitotoxicity by enhancing glial glutamate uptake. PLoS One. 2010;5(1):e8550. https://doi.org/10.1371/journal.pone.0008550
Uzbekov M, Shikhov S. Ciliary neurotrophic factor disturbances in patients with melancholic depression. Biomedical Journal of Scientific and Technical Research. 2019;13(3):1-2.
Musina LO, Uzbekov MG. Changes in the ciliary neurotrophic factor are related to the degree of severity of epilepsy. Neurochem J. 2017;11(1):112-114.
Kang SS, Keasey MP, Cai J, Hagg T. Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice. J Neurosci. 2012;32(27):9277-9287. https://doi.org/10.1523/JNEUROSCI.1746-12.2012
Lo DC. A central role for ciliary neurotrophic factor? Proc Natl Acad Sci USA. 1993;90(7):2557-2558. https://doi.org/10.1073/pnas.90.7.2557
Uzbekov M, Musina L. Serum ciliary neurotrophic factor concentration as a potential biomarker of efficacy of citicoline pharmacotherapy of temporal-lobe epilepsy in women. Theranostics of Brain, Spine & Neural Disorders. 2018;3(4):1-2.
Saver ZhL. Citicoline: new information about a promising drug that performs neuroprotection and neuropreparation. Mezhdunarodnyi Nevrologicheskii Zhurnal. 2010;1:108-117. (In Russ.).
Uzbekov MG. Endogenous intoxication and its role in the pathogenetic mechanisms of mental disorders. Sotsial’naya i Klinicheskaya Psikhiatriya. 2019;29(3):14-20. (In Russ.).
Maksimova NM, Bulgakova TS, Uzbekov MG. The role of cytokines in the pathogenesis and therapy of mental disorders. Sotsial’naya i Klinicheskaya Psikhiatriya. 2019;29(3):71-77. (In Russ.).
Morris G, Fernandes BS, Puri BK, et al. Leaky brain in neurological and psychiatric disorders: Drivers and consequences. Aust NZJ Psychiatry. 2018;52(10):924-948. https://doi.org/10.1177/0004867418796955

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