Alternative methods of therapy for comorbid sleep disorders as a method of choice in adult patients with epilepsy

Close metadata

OBJECTIVE

Systematization and generalization of data from domestic and foreign literature on alternative methods of treatment of sleep disorders in epilepsy.

MATERIAL AND METHODS

The search for data from domestic and foreign literary sources was carried out in the electronic databases Medline (PubMed), Scopus, Web of Science, eLibrary, CyberLeninka, Google Scholar.

RESULTS

The data of modern randomized trials, meta-analyzes on the effectiveness of various non-traditional methods as a method of choice for epilepsy with comorbid sleep disorders have been analyzed.

CONCLUSIONS

Complementary (alternative) treatments have many advantages over the classical pharmacotherapy of sleep disorders in epilepsy, in the form of non-invasiveness, low incidence of side-effects, ease of use, and lack of a dose-dependent effect. Of course, the targets of most of the above methods are not focused and not very specific, and the sample size is too small to obtain impartial and meaningful clinical conclusions, but this once again emphasizes the urgent need for large-scale clinical trials, which is necessary to develop evidence-based treatments for comorbid sleep disorders in epilepsy.

Keywords:

sleep disorders

insomnia

parasomnias

sleep breathing disorders

restless leg syndrome

sleep-dependent epilepsy

alternative treatment methods

Authors:

Zhidik A.G.

State Research Center — Burnasyan Federal Medical Biophysical Center

ORCID: 0009-0000-9789-8790

Kozhokaru A.B.

State Research Center — Burnasyan Federal Medical Biophysical Center;
Central State Medical Academy of Department of Presidential Affairs

ORCID: 0000-0001-9306-1686

Received:

14.03.2023

Accepted:

22.03.2023

List of references:

Derry CP, Duncan S. Sleep and epilepsy. Epilepsy Behav. 2013;26(3):394-404. https://doi.org/10.1016/j.yebeh.2012.10.033
Thomas RH, King WH, Johnston JA, Smith PE. Awake seizures after pure sleep-related epilepsy: a systematic review and implications for driving law. J Neurol Neurosurg Psychiatry. 2010;81(2):130-135. https://doi.org/10.1136/jnnp.2009.181438
Herman ST, Walczak TS, Bazil CW. Distribution of partial seizures during the sleep — wake cycle: differences by seizure onset site. Neurology. 2001;56(11):1453-1459. https://doi.org/10.1212/wnl.56.11.1453
Ferlisi M, Shorvon S. Seizure precipitants (triggering factors) in patients with epilepsy. Epilepsy Behav. 2014;33:101-105. https://doi.org/10.1016/j.yebeh.2014.02.019
Rajna P, Veres J. Correlations between night sleep duration and seizure frequency in temporal lobe epilepsy. Epilepsia. 1993;34(3):574-579. https://doi.org/10.1111/j.1528-1157.1993.tb02598.x
Fountain NB, Kim JS, Lee SI. Sleep deprivation activates epileptiform discharges independent of the activating effects of sleep. J Clin Neurophysiol. 1998;15(1):69-75. https://doi.org/10.1097/00004691-199801000-00009
Ellingson RJ, Wilken K, Bennett DR. Efficacy of sleep deprivation as an activation procedure in epilepsy patients. J Clin Neurophysiol. 1984;1(1):83-101. https://doi.org/10.1097/00004691-198401000-00005
Durazzo TS, Spencer SS, Duckrow RB, et al. Temporal distributions of seizure occurrence from various epileptogenic regions. Neurology. 2008;70(15):1265-1271. https://doi.org/10.1212/01.wnl.0000308938.84918.3f
Brutyan AG, Belyakova-Bodina AI. Epilepsiya i son. Annaly klinicheskoi i eksperimental’noi nevrologii. 2018;12(Spetsial’nyi vypusk):105-110. (In Russ.). https://doi.org/10.25692/ACEN.2018.5.14
Geyer JD, Geyer EE, Fetterman Z, Carney PR. Epilepsy and restless legs syndrome. Epilepsy Behav. 2017;68:41-44. https://doi.org/10.1016/j.yebeh.2016.12.010
Latreille V, St Louis EK, Pavlova M. Co-morbid sleep disorders and epilepsy: A narrative review and case examples. Epilepsy Res. 2018;145:185-197. https://doi.org/10.1016/j.eplepsyres.2018.07.005
Planas-Ballvé A, Grau-López L, Jiménez M, et al. Insomnia and poor sleep quality are associated with poor seizure control in patients with epilepsy. Neurologia (Engl Ed). 2022;37(8):639-646. https://doi.org/10.1016/j.nrleng.2019.07.008
Çilliler AE, Güven B. Sleep quality and related clinical features in patients with epilepsy: A preliminary report. Epilepsy Behav. 2020;102:106661. https://doi.org/10.1016/j.yebeh.2019.106661
Jain SV, Glauser TA. In response: Effects of epilepsy treatments on sleep architecture and daytime sleepiness: an evidence-based review of objective sleep metrics. Epilepsia. 2014;55(5):778. https://doi.org/10.1111/epi.12597
Malow BA, Levy K, Maturen K, Bowes R. Obstructive sleep apnea is common in medically refractory epilepsy patients. Neurology. 2000;55(7):1002-1007. https://doi.org/10.1212/wnl.55.7.1002
McCarter AR, Timm PC, Shepard PW, et al. Obstructive sleep apnea in refractory epilepsy: A pilot study investigating frequency, clinical features, and association with risk of sudden unexpected death in epilepsy. Epilepsia. 2018;59(10):1973-1981. https://doi.org/10.1111/epi.14548
Surges R, Thijs RD, Tan HL, Sander JW. Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms. Nat Rev Neurol. 2009;5(9):492-504. https://doi.org/10.1038/nrneurol.2009.118
Nobili L, Proserpio P, Rubboli G, et al. Sudden unexpected death in epilepsy (SUDEP) and sleep. Sleep Med Rev. 2011;15(4):237-246. https://doi.org/10.1016/j.smrv.2010.07.006
Derry CP. The sleep manifestations of frontal lobe epilepsy. Curr Neurol Neurosci Rep. 2011;11(2):218-226. https://doi.org/10.1007/s11910-011-0180-4
Thurman DJ, Hesdorffer DC, French JA. Sudden unexpected death in epilepsy: assessing the public health burden. Epilepsia. 2014;55(10):1479-1485. https://doi.org/10.1111/epi.12666
Mesraoua B, Tomson T, Brodie M, Asadi-Pooya AA. Sudden unexpected death in epilepsy (SUDEP): Definition, epidemiology, and significance of education. Epilepsy Behav. 2022;132:108742. https://doi.org/10.1016/j.yebeh.2022.108742
Ohayon MM, Schenck CH. Violent behavior during sleep: prevalence, comorbidity and consequences. Sleep Med. 2010;11(9):941-946. https://doi.org/10.1016/j.sleep.2010.02.016
Frauscher B, Gschliesser V, Brandauer E, et al. REM sleep behavior disorder in 703 sleep-disorder patients: the importance of eliciting a comprehensive sleep history. Sleep Med. 2010;11(2):167-171. https://doi.org/10.1016/j.sleep.2009.03.011
Kang SH, Yoon IY, Lee SD, et al. REM sleep behavior disorder in the Korean elderly population: prevalence and clinical characteristics. Sleep. 2013;36(8):1147-1152. https://doi.org/10.5665/sleep.2874
Boot BP, Boeve BF, Roberts RO, et al. Probable rapid eye movement sleep behavior disorder increases risk for mild cognitive impairment and Parkinson disease: a population-based study. Ann Neurol. 2012;71(1):49-56. https://doi.org/10.1002/ana.22655
Mahlknecht P, Seppi K, Frauscher B, et al. Probable RBD and association with neurodegenerative disease markers: A population-based study. Mov Disord. 2015;30(10):1417-1421. https://doi.org/10.1002/mds.26350
Adler CH, Hentz JG, Shill HA, et al. Probable RBD is increased in Parkinson’s disease but not in essential tremor or restless legs syndrome. Parkinsonism Relat Disord. 2011;17(6):456-458. https://doi.org/10.1016/j.parkreldis.2011.03.007
Tang WK, Hermann DM, Chen YK, et al. Brainstem infarcts predict REM sleep behavior disorder in acute ischemic stroke. BMC Neurol. 2014;14:88. https://doi.org/10.1186/1471-2377-14-88
Wing YK, Lam SP, Li SX, et al. REM sleep behaviour disorder in Hong Kong Chinese: clinical outcome and gender comparison. J Neurol Neurosurg Psychiatry. 2008;79(12):1415-1416. https://doi.org/10.1136/jnnp.2008.155374
Postuma RB, Gagnon JF, Vendette M, et al. Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology. 2009;72(15):1296-1300. https://doi.org/10.1212/01.wnl.0000340980.19702.6e
Iranzo A, Fernández-Arcos A, Tolosa E, et al. Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patients. PLoS One. 2014;9(2):e89741. https://doi.org/10.1371/journal.pone.0089741
Olson EJ, Boeve BF, Silber MH. Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases. Brain. 2000;123(Pt 2):331-339. https://doi.org/10.1093/brain/123.2.331
Fernández-Arcos A, Iranzo A, Serradell M, et al. The Clinical Phenotype of Idiopathic Rapid Eye Movement Sleep Behavior Disorder at Presentation: A Study in 203 Consecutive Patients. Sleep. 2016;39(1):121-132. https://doi.org/10.5665/sleep.5332
Menghi V, Bisulli F, Tinuper P, Nobili L. Sleep-related hypermotor epilepsy: prevalence, impact and management strategies. Nat Sci Sleep. 2018;10:317-326. https://doi.org/10.2147/NSS.S152624
Cornejo-Sanchez DM, Carrizosa-Moog J, Cabrera-Hemer D, et al. Sleepwalking and Sleep Paralysis: Prevalence in Colombian Families With Genetic Generalized Epilepsy. J Child Neurol. 2019;34(9):491-498. https://doi.org/10.1177/0883073819842422
McElroy-Cox C. Alternative approaches to epilepsy treatment. Curr Neurol Neurosci Rep. 2009;9(4):313-318. https://doi.org/10.1007/s11910-009-0047-0
McLaughlin DP, McFarland K. A randomized trial of a group based cognitive behavior therapy program for older adults with epilepsy: the impact on seizure frequency, depression and psychosocial well-being. J Behav Med. 2011;34(3):201-207. https://doi.org/10.1007/s10865-010-9299-z
Tang V, Poon WS, Kwan P. Mindfulness-based therapy for drug-resistant epilepsy: An assessor-blinded randomized trial. Neurology. 2015;85(13):1100-1107. https://doi.org/10.1212/WNL.0000000000001967
Kanhere SV, Bagadia DR, Phadke VD, Mukherjee PS. Yoga in Children with Epilepsy: A Randomized Controlled Trial. J Pediatr Neurosci. 2018;13(4):410-415. https://doi.org/10.4103/JPN.JPN_88_18
Morales-Quezada L, Martinez D, El-Hagrassy MM, et al. Neurofeedback impacts cognition and quality of life in pediatric focal epilepsy: An exploratory randomized double-blinded sham-controlled trial. Epilepsy Behav. 2019;101(Pt A):106570. https://doi.org/10.1016/j.yebeh.2019.106570
Peng WF, Wang X, Hong Z, et al. The anti-depression effect of Xylaria nigripes in patients with epilepsy: A multicenter randomized double-blind study. Seizure. 2015;29:26-33. https://doi.org/10.1016/j.seizure.2015.03.014
Joo EY, Han SJ, Chung SH, et al. Antiepileptic effects of low-frequency repetitive transcranial magnetic stimulation by different stimulation durations and locations. Clin Neurophysiol. 2007;118(3):702-708. https://doi.org/10.1016/j.clinph.2006.11.008
Sun W, Mao W, Meng X, et al. Low-frequency repetitive transcranial magnetic stimulation for the treatment of refractory partial epilepsy: a controlled clinical study. Epilepsia. 2012;53(10):1782-1789. https://doi.org/10.1111/j.1528-1167.2012.03626.x
Schachter SC. Botanicals and herbs: a traditional approach to treating epilepsy. Neurotherapeutics. 2009;6(2):415-420. https://doi.org/10.1016/j.nurt.2008.12.004
Sucher NJ, Carles MC. A pharmacological basis of herbal medicines for epilepsy. Epilepsy Behav. 2015;52(Pt B):308-318. https://doi.org/10.1016/j.yebeh.2015.05.012
Ko HJ, Song A, Lai MN, Ng LT. Antioxidant and antiradical activities of Wu Ling Shen in a cell free system. Am J Chin Med. 2009;37(4):815-828. https://doi.org/10.1142/S0192415X09007260
Ko HJ, Song A, Lai MN, Ng LT. Immunomodulatory properties of Xylaria nigripes in peritoneal macrophage cells of Balb/c mice. J Ethnopharmacol. 2011;138(3):762-768. https://doi.org/10.1016/j.jep.2011.10.022
Gibbon FM, Maccormac E, Gringras P. Sleep and epilepsy: unfortunate bedfellows. Arch Dis Child. 2019;104(2):189-192. https://doi.org/10.1136/archdischild-2017-313421
Saadeh C, Ulualp SO. The Effect of Tonsillectomy and Adenoidectomy on Isolated Sleep Associated Hypoventilation in Children. Laryngoscope. 2021;131(4):1380-1382. https://doi.org/10.1002/lary.29079
Pornsriniyom D, Kim Hw, Bena J, et al. Effect of positive airway pressure therapy on seizure control in patients with epilepsy and obstructive sleep apnea. Epilepsy Behav. 2014;37:270-275. https://doi.org/10.1016/j.yebeh.2014.07.005
Malow BA, Foldvary-Schaefer N, Vaughn BV, et al. Treating obstructive sleep apnea in adults with epilepsy: a randomized pilot trial. Neurology. 2008;71(8):572-577. https://doi.org/10.1212/01.wnl.0000323927.13250.54
Oh DM, Johnson J, Shah B, et al. Treatment of vagus nerve stimulator-induced sleep-disordered breathing: A case series. Epilepsy Behav Rep. 2019;12:100325. https://doi.org/10.1016/j.ebr.2019.100325
Vendrame M, Auerbach S, Loddenkemper T, et al. Effect of continuous positive airway pressure treatment on seizure control in patients with obstructive sleep apnea and epilepsy. Epilepsia. 2011;52(11):168-171. https://doi.org/10.1111/j.1528-1167.2011.03214.x
Pornsriniyom D, Shinlapawittayatorn K, Fong J, et al. Continuous positive airway pressure therapy for obstructive sleep apnea reduces interictal epileptiform discharges in adults with epilepsy. Epilepsy Behav. 2014;37:171-174. https://doi.org/10.1016/j.yebeh.2014.06.025
van Dijkman SC, de Jager NCB, Rauwé WM, et al. Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials. Clin Pharmacokinet. 2018;57(8):1039-1053. https://doi.org/10.1007/s40262-017-0614-5
Yang D, Wang Q, Xu C, et al. Transcranial direct current stimulation reduces seizure frequency in patients with refractory focal epilepsy: A randomized, double-blind, sham-controlled, and three-arm parallel multicenter study. Brain Stimul. 2020;13(1):109-116. https://doi.org/10.1016/j.brs.2019.09.006
Frase L, Piosczyk H, Zittel S, et al. Modulation of Total Sleep Time by Transcranial Direct Current Stimulation (tDCS). Neuropsychopharmacology. 2016;41(10):2577-2586. https://doi.org/10.1038/npp.2016.65
Frase L, Selhausen P, Krone L, et al. Differential effects of bifrontal tDCS on arousal and sleep duration in insomnia patients and healthy controls. Brain Stimul. 2019;12(3):674-683. https://doi.org/10.1016/j.brs.2019.01.001
Riemann D, Baglioni C, Bassetti C, et al. European guideline for the diagnosis and treatment of insomnia. J Sleep Res. 2017;26(6):675-700. https://doi.org/10.1111/jsr.12594
McLaughlin DP, McFarland K. A randomized trial of a group based cognitive behavior therapy program for older adults with epilepsy: the impact on seizure frequency, depression and psychosocial well-being. J Behav Med. 2011;34(3):201-207. https://doi.org/10.1007/s10865-010-9299-z
Blocher JB, Fujikawa M, Sung C, et al. Computer-assisted cognitive behavioral therapy for children with epilepsy and anxiety: a pilot study. Epilepsy Behav. 2013;27(1):70-76. https://doi.org/10.1016/j.yebeh.2012.12.014
Gandy M, Karin E, Fogliati VJ, et al. A feasibility trial of an Internet-delivered and transdiagnostic cognitive behavioral therapy treatment program for anxiety, depression, and disability among adults with epilepsy. Epilepsia. 2016;57(11):1887-1896. https://doi.org/10.1111/epi.13569
Macrodimitris S, Wershler J, Hatfield M, et al. Group cognitive-behavioral therapy for patients with epilepsy and comorbid depression and anxiety. Epilepsy Behav. 2011;20(1):83-88. https://doi.org/10.1016/j.yebeh.2010.10.028
Panebianco M, Sridharan K, Ramaratnam S. Yoga for epilepsy. Cochrane Database Syst Rev. 2017;10(10):CD001524. https://doi.org/10.1002/14651858.CD001524.pub3
Yang C, Hao Z, Zhang LL, Guo Q. Efficacy and safety of acupuncture in children: an overview of systematic reviews. Pediatr Res. 2015;78(2):112-119. https://doi.org/10.1038/pr.2015.91
Cheuk DK, Wong V. Acupuncture for epilepsy. Cochrane Database Syst Rev. 2014;(5):CD005062. https://doi.org/10.1002/14651858.CD005062.pub4
Lee SH, Lim SM. Acupuncture for insomnia after stroke: a systematic review and meta-analysis. BMC Complement Altern Med. 2016;16:228. https://doi.org/10.1186/s12906-016-1220-z
Yin X, Gou M, Xu J, et al. Efficacy and safety of acupuncture treatment on primary insomnia: a randomized controlled trial. Sleep Med. 2017;37:193-200. https://doi.org/10.1016/j.sleep.2017.02.012
Huang W, Johnson TM, Kutner NG, et al. Acupuncture for Treatment of Persistent Disturbed Sleep: A Randomized Clinical Trial in Veterans With Mild Traumatic Brain Injury and Posttraumatic Stress Disorder. J Clin Psychiatry. 2018;80(1):18m12235. https://doi.org/10.4088/JCP.18m12235
Leeman-Markowski BA, Schachter SC. Cognitive and Behavioral Interventions in Epilepsy. Curr Neurol Neurosci Rep. 2017;17(5):42. https://doi.org/10.1007/s11910-017-0752-z
Melo DLM, Carvalho LBC, Prado LBF, Prado GF. Biofeedback Therapies for Chronic Insomnia: A Systematic Review. Appl Psychophysiol Biofeedback. 2019;44(4):259-269. https://doi.org/10.1007/s10484-019-09442-2
Schabus M, Griessenberger H, Gnjezda MT, et al. Better than sham? A double-blind placebo-controlled neurofeedback study in primary insomnia. Brain. 2017;140(4):1041-1052. https://doi.org/10.1093/brain/awx011

Close metadata