A complex of B vitamins, choline and inosine in the treatment of chronic pain

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Chronic pain is an independent disease associated with multiple changes in the nervous, endocrine and immune systems. The use of B vitamins is pathogenetically justified. Unlike others, the CompligamB complex contains almost all fractions of B vitamins, inosine and para-aminobenzoic acid, which provides an additional therapeutic effect. The effects of vitamins are summarized, in some cases they are potentiated, while none of them can replace the other, so it is advisable to use vitamin complexes.

Keywords:

chronic pain

B complex vitamins

choline

inosine

CompligamB

Authors:

Putilina M.V.

Pirogov Russian National Research Medical University

ORCID: 0000-0002-8655-8501

Received:

15.02.2023

Accepted:

16.02.2023

List of references:

Fitzcharles MA, Cohen SP, Clauw DJ, et al. Nociplastic pain: towards an understanding of prevalent pain conditions. Lancet. 2021;397(10289):2098-2110. https://doi.org/10.1016/S0140-6736(21)00392-5
Cohen SP, Vase L, Hooten WM. Chronic pain: an update on burden, best practices, and new advances. Lancet. 2021;397(10289):2082-2097. https://doi.org/10.1016/S0140-6736(21)00393-7
Dagnino APA, Campos MM. Chronic Pain in the Elderly: Mechanisms and Perspectives. Front Hum Neurosci. 2022;16:736688. https://doi.org/10.3389/fnhum.2022.736688
Çoban Ö. Several Dosage Forms Containing Vitamin B and Their Use in Therapy. B-Complex Vitamins — Sources, Intakes and Novel Applications. IntechOpen. 2022. https://doi.org/10.5772/intechopen.99645
Shakoor H, Feehan J, Mikkelsen K, et al. Be well: A potential role for vitamin B in COVID-19. Maturitas. 2021;144(9):108-111. https://doi.org/10.1016/j.maturitas.2020.08.007
Cox MA, Bassi C, Saunders ME, et al. Beyond neurotransmission: acetylcholine in immunity and inflammation. J Intern Med. 2020;287(6):120-133.
Lu J, Wu W. Cholinergic modulation of the immune system — A novel therapeutic target for myocardial inflammation. Int Immunopharmacol. 2021;93(6):23-29. https://doi.org/10.1016/j.intimp.2021.107391
Alibekova DM, Saidov MB, Abdulkhanov MR. Modern ideas about the structure and functions of acetylcholinesterase. Bulletin of the Dagestan State University. Series 1: Natural Sciences. 2018;2:34-39. (In Russ.).
Rocha-Resende C, Mendes da Silva A, Prado M. Protective and anti-inflammatory effects of acetylcholine in the heart. Am J Physiol. 2021;320(2):155-161. https://doi.org/10.1152/ajpcell.00315.2020
Putilina MV. Endothelium as a target for new therapeutic strategies in cerebral vascular diseases. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2017;117(10):122-130. (In Russ.). https://doi.org/10.17116/jnevro2017117101122-130
Norat P, Soldozy S, Sokolowski JD, et al. Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation. NPJ Regen Med. 2020;5(1):22-28. https://doi.org/10.1038/s41536-020-00107-x
Dhanasobhon D, Medrano MC, Becker L, et al. Enhanced analgesic cholinergic tone in the spinal cord in a mouse model of neuropathic pain. Neurobiol Dis. 2021;155:105363. https://doi.org/10.1016/j.nbd.2021.105363
En-Nosse M, Hartmann S, Trinkaus K, et al. Expression of non-neuronal cholinergic system in osteoblast-like cells and its involvement in osteogenesis. Cell Tissue Res. 2009;338(7):203-215. https://doi.org/10.1007/s00441-009-0871-1
Moretti A, Paoletta M, Liguori S, et al. Choline: An Essential Nutrient for Skeletal Muscle. Nutrients. 2020;12(7):2144. https://doi.org/10.3390/nu12072144
Spieker J, Frieß JL, Sperling L, et al. Cholinergic control of bone development and beyond. Int Immunopharmacol. 2020;83(6):67-72. https://doi.org/10.1016/j.intimp.2020.106405
Putilina MV. A personalized selection of choline precursors in evidence — based medicine. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2020;120(6):144-151. (In Russ.). https://doi.org/10.17116/jnevro2020120061144
Calderón-Ospina CA, Nava-Mesa MO. B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin. CNS Neurosci Ther. 2020;26(1):5-13. https://doi.org/10.1111/cns.13207
Plantone D, Pardini M, Rinaldi G. Riboflavin in Neurological Diseases: A Narrative Review. Clin Drug Investig. 2021;41(6):513-527. https://doi.org/10.1007/s40261-021-01038-1
Badawy A. Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide. Biosci Rep. 2020;40(10):BSR20202856. https://doi.org/10.1042/BSR20202856
Thompson DF, Saluja HS. Prophylaxis of migraine headaches with riboflavin: A systematic review. J Clin Pharm Ther. 2017;42(4):394-403. https://doi.org/10.1111/jcpt.12548
Gasperi V, Sibilano M, Savini I, Catani MV. Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications. Int J Mol Sci. 2019;20(4):974. https://doi.org/10.3390/ijms20040974
Xu J, Patassini S, Begley P, et al. Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer’s disease. Biochem Biophys Res Commun. 2020;527(3):676-681. https://doi.org/10.1016/j.bbrc.2020.05.015
Saleem F, Soos MP. Biotin Deficiency. [Updated 2022 Mar 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. https://www.ncbi.nlm.nih.gov/books/NBK547751/
Reynolds EH. The neurology of folic acid deficiency. Handb Clin Neurol. 2014;120:927-943. https://doi.org/10.1016/B978-0-7020-4087-0.00061-9
Tamaddonfard E, Tamaddonfard S, Cheraghiyan S. Effects of intracerebroventricular injection of vitamin B12 on formalin-induced muscle pain in rats: Role of cyclooxygenase pathway and opioid receptors. Vet Res Forum. 2018;9(4):329-335.
Mahdavifar B, Hosseinzadeh M, Salehi-Abargouei A, et al. Dietary intake of B vitamins and their association with depression, anxiety, and stress symptoms: A cross-sectional, population-based survey. J Affect Dis. 2021;288:92-98. https://doi.org/10.1016/j.jad.2021.03.055
Chatree S, Thongmaen N, Tantivejkul K, et al. Role of Inositols and Inositol Phosphates in Energy Metabolism. Molecules. 2020;25(21):5079. https://doi.org/10.3390/molecules25215079
Chhetri DR. Myo-Inositol and Its Derivatives: Their Emerging Role in the Treatment of Human Diseases. Front Pharmacol. 2019;10:1172. https://doi.org/10.3389/fphar.2019.01172
Sawalha K. Treatment of scleroderma with para-aminobenzoic acid: effect on disease morbidity. Arch Gen Intern Med. 2018;2(3):19-22. https://doi.org/10.4066/2591-7951.1000052
Putilina MV. Features of the treatment of asthenic disorders. Consilicum Medicum. Neurology and rheumatology. 2010;12(1):30-35. (In Russ.).

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