Clinical and neurophysiological parameters in patients with epilepsy in the long-term period after COVID-19

Selitsky G.V.; Sorokina N.D.; Pertsov S.S.; Zherdeva A.S.; Tsagashek A.V.

doi:https://doi.org/10.17116/jnevro202312302160

Selitsky G.V.

Evdokimov Moscow State University of Medicine and Dentistry

Sorokina N.D.

Evdokimov Moscow State University of Medicine and Dentistry

Pertsov S.S.

Anokhin Research Institute of Normal Physiology;
Evdokimov Moscow State University of Medicine and Dentistry

Zherdeva A.S.

Evdokimov Moscow State University of Medicine and Dentistry

Tsagashek A.V.

Evdokimov Moscow State University of Medicine and Dentistry

Clinical and neurophysiological parameters in patients with epilepsy in the long-term period after COVID-19

Authors:

Selitsky G.V., Sorokina N.D., Pertsov S.S., Zherdeva A.S., Tsagashek A.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(2): 60‑65

DOI: 10.17116/jnevro202312302160

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To cite this article:

Selitsky GV, Sorokina ND, Pertsov SS, Zherdeva AS, Tsagashek AV. Clinical and neurophysiological parameters in patients with epilepsy in the long-term period after COVID-19. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(2):60‑65. (In Russ.)
https://doi.org/10.17116/jnevro202312302160

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

Clinical and psychophysiological assessment of the dynamics of the condition of patients with epilepsy in 4-6 months after the coronavirus infection.

MATERIAL AND METHODS

An open controlled prospective comparative outpatient clinical and physiological study of patients diagnosed with epilepsy after suffering from COVID-19 (after 4—6 months) of moderate severity (n=16), patients diagnosed with epilepsy who did not suffer from COVID-19 (n=7), a control group (n=11) after confirmed COVID-19 (after 4—6 months). All groups were in the age range 23 to 50 years. Clinical/neurological and somatic research included: anamnesis, neurological examination, questioning, ECG, EEG, clinical and psychometric tests.

RESULTS

There was an increase in the representation of epileptiform activity in the background EEG and more pronounced activity in provoking samples compared with background recording in 26.5% of patients who had suffered COVID-19 compared with the group of patients with epilepsy who had not suffered COVID-19. The detection of rare epileptic seizures in 18.8% of cases in the group of epilepsy patients, who underwent COVID-19, indicates an increase in epileptogenesis and a decrease in therapeutic control over seizures. At the same time, 87.5% of patients in this group showed a statistically significant increase in the influence of the sympathetic nervous system on the regulation of heart rhythm and an increase in anxiety and depression.

CONCLUSION

The results can complement the understanding of the neuropsychiatric status of patients with epilepsy after COVID-19, which provides prerequisites for the development of optimal recovery directions in the rehabilitation period to maintain drug remission of epilepsy and reduce the possible progression of the disease.

Keywords:

epilepsy

COVID-19

heart rate variability

bioelectric activity of the brain

autonomous nervous system

Authors:

Selitsky G.V.

Evdokimov Moscow State University of Medicine and Dentistry

Sorokina N.D.

Evdokimov Moscow State University of Medicine and Dentistry

Pertsov S.S.

Anokhin Research Institute of Normal Physiology;
Evdokimov Moscow State University of Medicine and Dentistry

Zherdeva A.S.

Evdokimov Moscow State University of Medicine and Dentistry

Tsagashek A.V.

Evdokimov Moscow State University of Medicine and Dentistry

Received:

29.09.2022

Accepted:

12.10.2022

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References:

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