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Berezutsky M.A.

Razumovsky Saratov State Medical University

Durnova N.A.

Razumovsky Saratov State Medical University

Romanteeva Yu.V.

Razumovsky Saratov State Medical University

Neurobiological effects of gastrodin and its possible use in neurology and psychiatry

Authors:

Berezutsky M.A., Durnova N.A., Romanteeva Yu.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(8): 27‑34

DOI: 10.17116/jnevro202212208127

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NEUROBIOLOGICAL EFFECTS OF GASTRODIN AND ITS POSSIBLE USE IN NEUROLOGY AND PSYCHIATRY
NEUROBIOLOGICAL EFFECTS OF GASTRODIN AND ITS POSSIBLE USE IN NEUROLOGY AND PSYCHIATRY

To cite this article:

Berezutsky MA, Durnova NA, Romanteeva YuV. Neurobiological effects of gastrodin and its possible use in neurology and psychiatry. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(8):27‑34. (In Russ.)
https://doi.org/10.17116/jnevro202212208127

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

Gastrodin is the main biologically active component of the rhizomes of the Gastrodia elata Blume. In recent years, this compound has attracted attention through a wide range of neurobiological effects. The neuroprotective effect of gastrodin on the brain after ischemic damage and exposure to toxic compounds has been determined. Gastrodin reduces amyloid beta deposition and excess glutamate, inhibits ferroptosis and restores electrophysiological parameters of synaptic plasticity. Moreover, this substance increases the level of brain-derived neurotrophic factor and stimulates neurogenesis. Studies have revealed the ability of gastrodin to reduce microglial activity and modulate dopamine concentration. Clinical studies have shown the effectiveness of this drug in the treatment of post-stroke depression. This compound also improves cognitive functions, including memory and learning. The anticonvulsant effect of gastrodin has been established. Theoretical justifications of application of gastrodin in certain neurodegenerative and convulsive diseases, as well as some mental disorders are given.

Keywords:

gastrodin
neurodegenerative diseases
memory
learning
epilepsy
depression

Authors:

Berezutsky M.A.

Razumovsky Saratov State Medical University

Durnova N.A.

Razumovsky Saratov State Medical University

Romanteeva Yu.V.

Razumovsky Saratov State Medical University

Received:

25.01.2022

Accepted:

31.01.2022

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References:

  1. Chen PJ, Hsieh CL, Su KP, et al. The Antidepressant Effect of Gastrodia elata Bl. on the Forced-Swimming Test in Rats. Am J Chin Med. 2008;36(1):95-106.  https://doi.org/10.1142/S0192415X08005618
  2. Li C, Chen X, Zhang N, Song Y, Mu Y. Gastrodin inhibits neuroinflammation in rotenone-induced Parkinson’s disease model rats. Neural Regen Res. 2012;7(5):325-331.  https://doi.org/10.3969/j.issn.1673-5374.2012.05.001
  3. Bai Y, Yin H, Bi H, et al. De novo biosynthesis of gastrodin in Escherichia coli. Metab Eng. 2016;35:138-147.  https://doi.org/10.1016/j.ymben.2016.01.002
  4. Zhang Z, Ma P, Xu Y, et al. Preventive effect of gastrodin on cognitive decline after cardiac surgery with cardiopulmonary bypass: a double-blind, randomized controlled study. J Huazhong Univ Sci Technolog Med Sci. 2011;31(1):120-127.  https://doi.org/10.1007/s11596-011-0162-4
  5. Lin LC, Chen YF, Tsai TR, Tsai TH. Analysis of brain distribution and biliary excretion of a nutrient supplement, gastrodin, in rat. Anal Chim Acta. 2007;590:173-179.  https://doi.org/10.1016/j.aca.2007.03.035
  6. Lin LC, Chen YF, Lee WC, et al. Pharmacokinetics of gastrodin and its metabolite p-hydroxybenzyl alcohol in rat blood, brain and bile by microdialysis coupled to LC-MS/MS. J Pharm Biomed Anal. 2008;48(3):909-917.  https://doi.org/10.1016/j.jpba.2008.07.013
  7. Majid A. Neuroprotection in stroke: past, present, and future. ISRN Neurol. 2014;2014:515716. https://doi.org/10.1155/2014/515716
  8. Khadzieva KhI, Chernikova IV, Milyutina NP, Plotnikov AA. Clinical and biochemical heterogeneity of Parkinson’s disease. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2020;120(12):80-85. (In Russ.). https://doi.org/10.17116/jnevro202012012180
  9. Jiang G, Hu Y, Liu L, et al. Gastrodin protects against MPP+-induced oxidative stress by up regulates heme oxygenase-1 expression through p38 MAPK/Nrf2 pathway in human dopaminergic cells. Neurochem Int. 2014;75:79-88.  https://doi.org/10.1016/j.neuint.2014.06.003
  10. Kumar H, Kim IS, More SV, et al. Gastrodin Protects Apoptotic Dopaminergic Neurons in a Toxin-Induced Parkinson’s Disease Model. Evid Based Complement Alternat Med. 2013;2013:514095. https://doi.org/10.1155/2013/514095
  11. Yan J, Yang Z, Zhao N, et al. Gastrodin protects dopaminergic neurons via insulin-like pathway in a Parkinson’s disease model. BMC Neurosci. 2019;20(1):31.  https://doi.org/10.1186/s12868-019-0512-x
  12. Berezutsky MA, Durnova NA, Andronova TA, Sinichkina OV. Alzheimer’s disease: experimental and clinical researches of chinese herbal medicine neurobiological effects (a review). Uspekhi gerontologii. 2020;33(2):273-281. (In Russ.). https://doi.org/10.34922/AE.2020.33.2.008
  13. Hu Y, Li C, Shen W. Gastrodin alleviates memory deficits and reduces neuropathology in a mouse model of Alzheimer’s disease. Neuropathology. 2014;34(4):370-377.  https://doi.org/10.1111/neup.12115
  14. Zhou NN, Zhu R, Zhao XM, et al. Effect and mechanism of gastrodin inhibiting β-amyloid plaques in brain of mice. Yao Xue Xue Bao. 2016;51(4):588-594. 
  15. Zhang JS, Zhou SF, Wang Q, et al. Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer’s disease. Neuroscience. 2016;325:1-9.  https://doi.org/10.1016/j.neuroscience.2016.03.024
  16. Malashenkova IK, Hailov NA, Krynskiy SA, et al. Glutamate dehydrogenase activity in platelets of patients with endogenous psychosis. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2016;116(3):39-43. (In Russ.). https://doi.org/10.17116/jnevro20161163139-43
  17. Li M, Qian S. Gastrodin Protects Neural Progenitor Cells Against Amyloid β (1—42)-Induced Neurotoxicity and Improves Hippocampal Neurogenesis in Amyloid β (1—42)-Injected Mice. J Mol Neurosci. 2016;60(1):21-32.  https://doi.org/10.1007/s12031-016-0758-z
  18. Zhao X, Zou Y, Xu H, et al. Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1/2-Nrf2 pathway. Brain Res. 2012;1482:13-21.  https://doi.org/10.1016/j.brainres.2012.09.010
  19. Long H, Ruan J, Zhang M, et al. Gastrodin alleviates Tourette syndrome via Nrf-2/HO-1/HMGB1/NF-kB pathway. J Biochem Mol Toxicol. 2019;33(10):e22389. https://doi.org/10.1002/jbt.22389
  20. Sun X, Zhang X, Jiang K, WuM. Gastrodin Attenuates Tourette Syndrome by Regulating EAATs and NMDA Receptors in the Striatum of Rats. Neuropsychiatr Dis Treat. 2021;17:2243-2255. https://doi.org/10.2147/NDT.S305925
  21. Jiang G, Wu H, Hu Y, et al. Gastrodin Inhibits Glutamate-Induced Apoptosis of PC12 Cells via Inhibition of CaMKII/ASK-1/p38 MAPK/p53 Signaling Cascade. Cell Mol Neurobiol. 2014;34(4):591-602.  https://doi.org/10.1007/s10571-014-0043-z
  22. Qi YH, Zhu R, Wang Q, et al. Early intervention with gastrodin reduces striatal neurotoxicity in adult rats with experimentally-induced diabetes mellitus. Mol Med Rep. 2019;19(4):3114-3122. https://doi.org/10.3892/mmr.2019.9954
  23. Jiang T, Chu J, Chen H, et al. Gastrodin Inhibits H2O2-Induced Ferroptosis through Its Antioxidative Effect in Rat Glioma Cell Line C6. Biol Pharm Bull. 2020;43(3):480-487.  https://doi.org/10.1248/bpb.b19-00824
  24. Wang Y, Li S, Wang M, et al. Gastrodin inhibits H2O2-induced ferroptosis of PC12 cells. Chinese J Pharmacol Toxicol. 2021;26(5):532-538. 
  25. Liu B, Li F, Shi J, et al. Gastrodin ameliorates subacute phase cerebral ischemia-reperfusion injury by inhibiting inflammation and apoptosis in rats. Mol Med Rep. 2016;14(5):4144-4152. https://doi.org/10.3892/mmr.2016.5785
  26. Mao XN, Zhou HJ, Yang XJ, et al. Neuroprotective effect of a novel gastrodin derivative against ischemic brain injury: involvement of peroxiredoxin and TLR4 signaling inhibition. Oncotarget. 2017;8(53):90979-90995. https://doi.org/10.18632/oncotarget.18773
  27. Sui Y, Bian L, Ai Q, et al. Gastrodin Inhibits Inflammasome Through the STAT3 Signal Pathways in TNA2 Astrocytes and Reactive Astrocytes in Experimentally Induced Cerebral Ischemia in Rats. Neuromolecular Med. 2019;21(3):275-286.  https://doi.org/10.1007/s12017-019-08544-8
  28. Peng Z, Wang S, Chen G, et al. Gastrodin alleviates cerebral ischemic damage in mice by improving anti-oxidant and anti-inflammation activities and inhibiting apoptosis pathway. Neurochem Res. 2015;40(4):661-673.  https://doi.org/10.1007/s11064-015-1513-5
  29. Bie X, Chen Y, Han J, et al. Effects of gastrodin on amino acids after cerebral ischemia-reperfusion injury in rat striatum. Asia Pac J Clin Nutr. 2007;16(suppl 1):305-308. 
  30. Qiu CW, Liu ZY, Zhang FL, et al. Post-stroke gastrodin treatment ameliorates ischemic injury and increases neurogenesis and restores the Wnt/β-Catenin signaling in focal cerebral ischemia in mice. Brain Res. 2019;1712:7-15.  https://doi.org/10.1016/j.brainres.2019.01.043
  31. Luo L, Kim SW, Lee HK, et al. Gastrodin exerts robust neuroprotection in the postischemic brain via its protective effect against Zn 2+-toxicity and its anti-oxidative effects in astrocytes. Anim Cells Syst (Seoul). 2018;22(6):429-437.  https://doi.org/10.1080/19768354.2018.1549099
  32. Liu X, Wu C, Hu X, et al. Gastrodin Attenuates Neuronal Apoptosis and Neurological Deficits after Experimental Intracerebral Hemorrhage. J Stroke Cerebrovasc Dis. 2020;29(1):104483. https://doi.org/10.1016/j.jstrokecerebrovasdis.2019.104483
  33. Jiao M, Yin K, Zhang T, et al. Effect of the SSeCKS-TRAF6 interaction on gastrodin-mediated protection against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced astrocyte activation and neuronal death. Chemosphere. 2019;226:678-686.  https://doi.org/10.1016/j.chemosphere.2019.04.003
  34. Wang L, Wang H, Duan Z, Zhang J, Zhang W. Mechanism of gastrodin in cell apoptosis in rat hippocampus tissue induced by desflurane. Exp Ther Med. 2018;15(3):2767-2772. https://doi.org/10.3892/etm.2018.5770
  35. Yong W, Xing TR, Wang S, et al. Protective Effects of Gastrodin on Lead-Induced Synaptic Plasticity Deficits in Rat Hippocampus. Planta Med. 2009;75(10):1112-1117. https://doi.org/10.1055/s-0029-1185452
  36. Sun G, Yuan Z, Zhang B, et al. Gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid. Neural Regen Res. 2012;7(12):891-895.  https://doi.org/10.3969/j.issn.1673-5374.2012.12.002
  37. Yang H, Li Q, Li L, et al. Gastrodin modified polyurethane conduit promotes nerve repair via optimizing Schwann cells function. Bioact Mater. 2021;8:355-367.  https://doi.org/10.1016/j.bioactmat.2021.06.020
  38. Wang H, Zhang R, Qiao Y, et al. Gastrodin ameliorates depression-like behaviors and up-regulates proliferation of hippocampal-derived neural stem cells in rats: Involvement of its anti-inflammatory action. Behav Brain Res. 2014;266:153-160.  https://doi.org/10.1016/j.bbr.2014.02.046
  39. Song C, Fang S, Lv G, Mei X. Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord. Neural Regen Res. 2013;8(15):1383-1389. https://doi.org/10.3969/j.issn.1673-5374.2013.15.005
  40. Zhang R, Peng Z, Wang H, et al. Gastrodin Ameliorates Depressive-Like Behaviors and Up-Regulates the Expression of BDNF in the Hippocampus and Hippocampal-Derived Astrocyte of Rats. Neurochem Res. 2014;39(1):172-179.  https://doi.org/10.1007/s11064-013-1203-0
  41. Lee B, Sur B, Yeom M, et al. Gastrodin reversed the traumatic stress-induced depressed-like symptoms in rats. J Nat Med. 2016;70(4):749-759.  https://doi.org/10.1007/s11418-016-1010-4
  42. Li G, Ma Y, Ji J, et al. Effects of gastrodin on 5-HT and neurotrophic factor in the treatment of patients with post-stroke depression. Exp Ther Med. 2018;16(6):4493-4498. https://doi.org/10.3892/etm.2018.6760
  43. Zuo W, Xu F, Zhang K, et al. Proliferation-enhancing effects of gastrodin on RSC96 Schwann cells by regulating ERK1/2 and PI3K signaling pathways. Biomed Pharmacother. 2016;84:747-753.  https://doi.org/10.1016/j.biopha.2016.09.106
  44. Shu Y, Luo T, Wang M, et al. Gastrodin promotes CNS myelination via a lncRNA Gm7237/miR-142a/MRF pathway. RNA Biol. 2021;18(9):1279-1290. https://doi.org/10.1080/15476286.2020.1841976
  45. Liu SJ, Liu XY, Li J, et al. Gastrodin attenuates microglia activation through renin-angiotensin system and Sirtuin3 pathway. Neurochem Int. 2018;120:49-63.  https://doi.org/10.1016/j.neuint.2018.07.012
  46. Guo J, Zhang XLZ, Bao ZR, et al. Gastrodin Regulates the Notch Signaling Pathway and Sirt3 in Activated Microglia in Cerebral Hypoxic-Ischemia Neonatal Rats and in Activated BV-2 Microglia. Neuromolecular Med. 2021;23(3):348-362.  https://doi.org/10.1007/s12017-020-08627-x
  47. Chen L, Liu X, Wang H, et al. Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen-Activated Protein Kinase-Associated Inflammatory Responses in Mice. Neurosci Bull. 2017;33(3):264-272.  https://doi.org/10.1007/s12264-016-0084-z
  48. Yao YY, Li R, Guo YJ, et al. Gastrodin Attenuates Lipopolysaccharide-Induced Inflammatory Response and Migration via the Notch-1 Signaling Pathway in Activated Microglia. Neuromolecular Med. 2021 Jun 09.  https://doi.org/10.1007/s12017-021-08671-1
  49. Zavadenko NN, Doronina OB, Nesterovsky YuE. Chronic tics and Tourette syndrome in children and adolescents: diagnostic and treatment characteristics. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2015;115(1):102-109. (In Russ.). https://doi.org/10.17116/jnevro201511511102-109
  50. Zhang F, Li A. Dual regulating effects of gastrodin on extracellular dopamine concentration in rats models of Tourette’s syndrome. Int J Neurosci. 2015;125(10):784-792.  https://doi.org/10.3109/00207454.2014.971455
  51. Wang Y, Zhao L, Li AY. Gastrodin — A potential drug used for the treatment of Tourette Syndrome. J Pharmacol Sci. 2021;145(3):289-295.  https://doi.org/10.1016/j.jphs.2021.01.005
  52. Wang X, Yan S, Wang A, Li Y, Zhang F. Gastrodin Ameliorates Memory Deficits in 3,3′-Iminodipropionitrile-Induced Rats: Possible Involvement of Dopaminergic System. Neurochem Res. 2014;39(8):1458-1466. https://doi.org/10.1007/s11064-014-1335-x
  53. Liu X, Wang M. Improving effects of gastrodin on learning and memory in model rats with Alzheimer disease induced by intra-hippocampal Aβ1-40 injection. Chinese J Pharmacol Toxicol. 2012;17(4):408-411.  https://doi.org/10.1186/1750-1326-7-S1-S15
  54. Shi R, Zheng C, Wang H, et al. Dementia Rat Model by Altering Amyloid and Tau Levels. Pharmacology. 2020;105:386-396.  https://doi.org/10.1159/000504056
  55. Lei X, Yefeng Y, Zou O. The role and mechanism of gastrodin in the medial prefrontal cortex autophagy of PTSD rats. Int J Clin Exp Pathol. 2020;13(5):989-994. 
  56. Wang X, Tanc Y, Zhang F. Ameliorative effect of gastrodin on 3,3′-iminodipropionitrile-induced memory impairment in rats. Neurosci Lett. 2015;594:40-45.  https://doi.org/10.1016/j.neulet.2015.03.049
  57. Wang X, Li P, Liu J, et al. Gastrodin Attenuates Cognitive Deficits Induced by 3,3′-Iminodipropionitrile. Neurochem Res. 2016;41(6):1401-1409. https://doi.org/10.1007/s11064-016-1845-9
  58. Chen TT, Zhou X, Xu YN, et al. Gastrodin ameliorates learning and memory impairment in rats with vascular dementia by promoting autophagy flux via inhibition of the Ca 2+/CaMKII signal pathway. Aging (Albany NY). 2021;13(7):9542-9565. https://doi.org/10.18632/aging.202667
  59. Liu ZH, Ma H, Wang WP, et al. Structure-activity relationship of gastrodin and parishins on learning and memory deficits induced by scopolamine. Yao Xue Xue Bao. 2016;51(5):743-748.  https://doi.org/10.16438/j.0513-4870.2016-0196
  60. Wang X, Chen L, Xu Y, et al. Gastrodin alleviates perioperative neurocognitive dysfunction of aged mice by suppressing neuroinflammation. Eur J Pharmacol. 2021;892:173734. https://doi.org/10.1016/j.ejphar.2020.173734
  61. Ye T, Meng X, Wang R, et al. Gastrodin Alleviates Cognitive Dysfunction and Depressive-Like Behaviors by Inhibiting ER Stress and NLRP3 Inflammasome Activation in db/db Mice. Int J Mol Sci. 2018;19(12):3977. https://doi.org/10.3390/ijms19123977
  62. Shao H, Yang Y, Qi A, et al. Gastrodin Reduces the Severity of Status Epilepticus in the Rat Pilocarpine Model of Temporal Lobe Epilepsy by Inhibiting Nav1.6 Sodium Currents. Neurochem Res. 2017;42(2):360-374.  https://doi.org/10.1007/s11064-016-2079-6
  63. Yang CS, Chiu SC, Liu PY, et al. Gastrodin alleviates seizure severity and neuronal excitotoxicities in the rat lithium-pilocarpine model of temporal lobe epilepsy via enhancing GABAergic transmission. J Ethnopharmacol. 2021;269:113751. https://doi.org/10.1016/j.jep.2020.113751
  64. An SJ, Park SK, Hwang IK, et al. Gastrodin decreases immunoreactivities of γ-aminobutyric acid shunt enzymes in the hippocampus of seizure-sensitive gerbils. J Neurosci Res. 2003;71(4):534-543.  https://doi.org/10.1002/jnr.10502
  65. Yang Y, Li Y, Han J, Wang Y. Gastrodin attenuates lithium-pilocarpine-induced epilepsy by activating AMPK-mediated PPARα in a juvenile rat model. Biosci Biotechnol Biochem. 2021;85(4):798-804.  https://doi.org/10.1093/bbb/zbab013
  66. Wang JQ, Han DN, Guan BY, et al. The therapeutic effect of gastrodin in treating chronic refractory epilepsy. Chin Gen Prac. 2005;8:1181-1182.
  67. Lu YA, Xu DJ. The study of EEG changes in epilepsy patients treated with gastrodin. Pharmac Clin Chin Mat Med. 2015;31(02):114.  https://doi.org/10.13412/j.cnki.zyyl.2015.02.049
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