The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Goryunov A.V.

Mental Health Research Center

Sergeeva O.E.

Mental Health Research Center

Experience of Teraligen usage in pediatric psychiatry

Authors:

Goryunov A.V., Sergeeva O.E.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(7): 142‑150

DOI: 10.17116/jnevro2022122071142

Read: 59698 times

Download PDF (RU)
Contact the author
Table of contents

EXPERIENCE OF TERALIGEN USAGE IN PEDIATRIC PSYCHIATRY
EXPERIENCE OF TERALIGEN USAGE IN PEDIATRIC PSYCHIATRY

To cite this article:

Goryunov AV, Sergeeva OE. Experience of Teraligen usage in pediatric psychiatry. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(7):142‑150. (In Russ.)
https://doi.org/10.17116/jnevro2022122071142

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
A clinical case of diabulimia in type 1 diabetes mellitus: Psychopathological mechanisms and psychosomatic rela­tionships. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4):118-123
Sleep diso­rders in imprinting diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):75-80
The effect of sleep and other medi­cal and social factors on a woman’s reproductive function. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):81-86
Analysis of cognitive status in patients with different noso­logies and clinical variants of very late mani­festing schi­zophreniform psychosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):88-93
The possibility of using neurotropic therapy in patients with persistent postural-perceptual dizziness. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):89-94
Modern concepts of sleep disturbances asso­ciated with mental diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):7-12
Asso­ciation of cortisol levels with psychopathological features of depression and therapeutic response in female patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):45-54
Psychosomatic sets of symptoms in schi­zotypal personality diso­rder. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7):46-54
Asso­ciation of sleep diso­rders with APOE gene poly­morphisms among the resi­dents aged 25—64 years of the Novo­sibirsk city: WHO «MONICA psychosocial study». Russian Journal of Preventive Medi­cine. 2025;(5):75-81
Clinical and morphological features of adenomatoid odontogenic tumor of the mandible in early childhood. Stomatology. 2025;(2):72-76
Abstract:

The data of studies on the use of Teraligen in various fields of clinical medicine — neurology, dermatology, gastroenterology, anesthesiology and psychiatry are presented. According to studies conducted in psychiatry, Teraligen is a drug for the balanced treatment of anxiety-phobic, behavioral and sleep disorders in children, both within neurotic conditions and in the structure of autistic and schizophrenic spectrum disorders. Based on 100 case histories of children aged 3 to 16 years, the experience of using Teraligen as part of mono- and combination therapy at a dosage of 1.25 mg to 50 mg/day in the treatment of autism spectrum disorders (n=31), psychotic disorders (n=18), schizotypal disorders (n=41), behavioral and emotional disorders on residual organic soil (n=10). A good clinical effect of Teraligen has been shown in anxiety-phobic, affective, somatovegetative disorders and sleep disorders in all identified nosologies. Good tolerability of Teraligen, the possibility of its use as part of complex therapy and the almost complete absence of adverse events, indicating the softness and balance of the drug were noted.

Keywords:

childhood
Teraligen
neurotic disorders
autism spectrum disorders (ASD)
schizophrenia
schizotypal disorder
behavioral disorders
sleep disorders

Authors:

Goryunov A.V.

Mental Health Research Center

Sergeeva O.E.

Mental Health Research Center

Received:

11.04.2022

Accepted:

11.04.2022

Close metadata

References:

  1. Courvoisier S, Ducrot R, Fournel J, et al. Proprietes pharmacologiques generales d’un nouveau derive de la pheniothiazine neuroleptique puissant a action neurovegetativ discrete, le chlorhydrate de (methyl-2 dimethylamino-3 propyl-1)-10 phenothiazine (6.549 RP). Arch Int Pharmacodyn Ther. 1958;115(1-2):90-113. 
  2. Hudson AL. A new drug for control of itching — Trimeprazine [10-(3-Dimethylamino-2-Methylpropyl)-Phenothiazine]. Can Med Assoc J. 1959;80(2):125. 
  3. Ibragimov DF. Alymemazine in medical practice. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2008;108(9):76-78. (In Russ.).
  4. Pushkarev DF. Alimemazine in psychiatric practice and general medicine (literature review). Psikhicheskie Rasstroistva v Obshchei Meditsine. 2013;1:56-61. (In Russ.). https://con-med.ru/magazines/psikhicheskie_rasstroystva_v_obshchey_meditsine-01-2013
  5. Bekker RA, Bykov YV. Alimemazine: application overview. Psychiatry and psychopharmacotherapy = Psikhiatriia i Psikhofarmakoterapiia. 2016;18(6):10-20. (In Russ.). https://psychiatr.ru/download/2903?view=1&name=Psi+6+2016%28Low%29.pdf
  6. Medvedev VE. Alimemazine in psychiatry and psychosomatic. Psychiatry and Psychopharmacotherapy = Psikhiatriia i Psikhofarmakoterapiia. 2018;20(3-4):26-33. (In Russ.).
  7. Roth BL, Craigo SC, Choudhary MS, et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994;268(3):1403-1410.
  8. Glusa E, Pertz HH. Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT2B receptors. Br J Pharmacol. 2000;130(3):692-698.  https://doi.org/10.1038/sj.bjp.0703341
  9. Savelev DV, Reznik AM, Chernov AS, et al. Alimemazine in treatment of agitation in schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2020;120(6-2):68-76. (In Russ.). https://doi.org/10.17116/jnevro202012006268
  10. Edin AS. To the question of the use of alimamazine (Teraligen) in patients with atopic dermatitis in combination with anxiety-depressive disorder. Consilium Medicum. 2018;20(2):145-150. (In Russ.). https://doi.org/10.26442/2075-1753_2018.2.145-150
  11. Pribytkov AA, Orlova EA. Psikhosomaticheskie rasstroistva s proiavleniiami v vide urtikarnoi sypi. Psychiatry and Psychopharmacotherapy. 2014;2:47-53. (In Russ.).
  12. Antao B, Ooi K, Ade-Ajayi N, Stevens Spitz L. Effectiveness of alimemazine in controlling retching after Nissen fundoplication. Journal of Pediatric Surgery. 2005;40:1737-1740.
  13. Demyanov IA, Boiko EO, Zaitseva OG, et al. The efficacy of alimemazine (solution for intramuscular injection) in complex with antidepressants in the treatment of anxiety and depressive disorders. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2019;119(8):32-37. (In Russ.). https://doi.org/10.17116/jnevro201911908132
  14. Morozova MA, Alekseev AA, Rupchev GE. Alimemazine: a convenient therapeutic tool for solving some complex problems in the treatment of functional psychotic disorders (clinical cases). Modern Therapy of Mental Disorders. 2017;2:40-43. (In Russ.).
  15. Poluektov MG. Narusheniia sna v detskom vozraste: prichiny i sovremennaia terapiia. Effektivnaia Farmakoterapiia. 2012;1:32-39. (In Russ.).
  16. Gurtler J, Goralsky G. Testing of theralene on 70 mentally-defective and unstable children and children with character disorders and mental retardation, in an I.M.P. medical unit. Rev Neuropshychiat Infant. 1961;9:284-287. 
  17. Simonoff EA, Stores G. Controlled trial of trimeprazine tart rate for night waking. Arch Disease Childhood. 1987;62(3):253-257.  https://doi.org/10.1136/adc.62.3.253
  18. Richman NA. Double blind trial of drug treatment in young children with waking problems. J Child Psychol Psychiat. 1985;26(4):591-598.  https://doi.org/10.1111/j.1469-7610.1985.tb01643.x
  19. Oftsti E. Alimemazine (Vallergan) an alternative to traditional hypnotic drugs. Tidsskr Nor Laegeforen. 1975;9(31):1796-1797.
  20. Goryunova AV, Goryunov AV. Classification metamorphoses of autism in child psychiatry. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2021;121(11 vyp 2):5-11. (In Russ.). https://doi.org/10.17116/jnevro20211211125
  21. Aleshina NV. The use of the drug «Teralidzhen» in the structure of pharmacotherapy of early childhood autism (procedural and organic). Mental health. 2014;12:2(93):70-72. (In Russ.).
  22. Aleshina NV, Filippova NV, Barylnik YuB. Teraligen in the complex therapy of organic and procedural early childhood autism. International Research Journal. 2014;2-3(21):89-90. (In Russ.).
  23. Aleshina NV. Therapy of autistic disorders with Teraligen (Alimemazine) in pediatric practice on an outpatient basis. Psychiatry and psychopharmacotherapy = Psikhiatriia i Psikhofarmakoterapiia. 2018;20(1):23-26. (In Russ.).
  24. Simashkova NV. Effective pharmacotherapy and rehabilitation of patients with autism spectrum disorders. Neurology and Psychiatry. 2011;3:14-22. (In Russ.).
  25. Zueva GA. Opyt primeneniia alimemazina tartrata dlia korrektsii narushenii sna u podrostkov s golovnoi bol’iu napriazheniia. V kn.: Aktual’nye voprosy reabilitatsii v nevrologii i psikhiatrii. Materialy nauchno-prakticheskoi konferentsii. Tver’: GBOU VPO Tverskaia GMA Minzdrava Rossii; 2014;16-18. (In Russ.).
  26. Chervin RD, Arcbhold KH, Panahi P, et al. Sleep problems seldom addressed at two general pediatrics clinics. Pediatrics. 2001;107(6)1375-1380. https://doi.org/10.1542/peds.107.6.1375
  27. Malinina EV, Chizhova TN, Zabozlaeva IV, et al. Study of the efficacy and tolerability of alimemazine in children with mixed disorder of emotions and behavior. Child neurology and psychiatry. 2015;106-107(5-6):67-70. (In Russ.).
  28. Mazaeva NA, Golovina AG. Alimemazine in outpatient therapy of non-psychotic mental disorders in adolescents. Psychiatry. 2015;1(65):11-16. (In Russ.).
  29. Balakireva EE. Eating disorders in children and adolescents. Psychiatry. 2013;4:16-21. (In Russ.).
  30. Goryunov AV. Using Lurasidone in the treatment of mental illness in childhood. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2021;121(11 issue 2):77-85. (In Russ.). https://doi.org/10.17116/jnevro202112111277
  31. Sychev DA, Otdelenov VA. Interdrug interactions in the practice of an internist: a clinical pharmacologist’s perspective. Reference Book of the Polyclinic doctor. 2014;12:18-21. (In Russ.).
  32. Kirilochev OO, Umerova AR, Dorfman IP, et al. The drug-drug interactions in a psychiatric hospital. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2017;117(5):26-30. (In Russ.). https://doi.org/10.17116/jnevro20171175126-30
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.