Efficiency of the attention networks and severity of positive and negative symptoms in schizophrenia

Pultsina K.I.; Alekhin A.N.; Petrova E.V.; Vorobjeva N.V.

doi:https://doi.org/10.17116/jnevro202212202188

Pultsina K.I.

Herzen University of Russia of the Department of Clinical Psychology and Psychological Treatment

Alekhin A.N.

Herzen University of Russia of the Department of Clinical Psychology and Psychological Treatment

Petrova E.V.

Novosibirsk State Medical University

ORCID: 0000-0003-3839-655X

Vorobjeva N.V.

Lomonosov Moscow State University

RSCI AuthorID: 95671
ORCID: 0000-0001-5233-9338

Efficiency of the attention networks and severity of positive and negative symptoms in schizophrenia

Authors:

Pultsina K.I., Alekhin A.N., Petrova E.V., Vorobjeva N.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(2): 88‑96

DOI: 10.17116/jnevro202212202188

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To cite this article:

Pultsina KI, Alekhin AN, Petrova EV, Vorobjeva NV. Efficiency of the attention networks and severity of positive and negative symptoms in schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(2):88‑96. (In Russ.)
https://doi.org/10.17116/jnevro202212202188

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To examine the characteristics of the event related potentials during the attention network test in patients with schizophrenia depending on the severity of positive and negative symptoms.

MATERIAL AND METHODS

The study included 20 patients with schizophrenia, 10 of them with a predominance of positive symptoms and 10 patients with a predominance of negative symptoms. All patients were diagnosed with paranoid schizophrenia (F20.0). Attention function was assessed using the attention network test with parallel recording of evoked responses. Differences in the amplitude and latency of N100 potential when presented with different types of cues, as well as P300 potential when identifying a congruent and incongruent flanker were analyzed.

RESULTS

A comparative analysis of N100 potential for neutral cues and flankers showed significantly lower amplitude and longer latency in the group of patients with a predominance of negative symptoms (Cz channel).The amplitude of the evoked N100 response upon presentation of central and spatial cues was significantly higher in the group of patients with a predominance of positive symptoms. An analysis of P300 potential in Fz channel with congruent and incongruent flankers revealed no differences in the amplitude of both stimuli in the group of patients with a predominance of negative symptoms, while the amplitude of the evoked response to congruent and incongruent flankers was significantly higher in the group with a predominance of positive symptoms. In the group of patients with a predominance of positive symptoms, an inverse flanker response was established — P300 amplitude was significantly higher upon presentation of an incongruent flanker.

CONCLUSION

The specific characteristics of evoked responses describing the features of such systems of attention as vigilance, orientation and conflict resolution have been established.

Keywords:

evoked potentials

attention

attention network test

schizophrenia

positive symptoms

negative symptoms

N100

P300

Authors:

Pultsina K.I.

Herzen University of Russia of the Department of Clinical Psychology and Psychological Treatment

Alekhin A.N.

Herzen University of Russia of the Department of Clinical Psychology and Psychological Treatment

Petrova E.V.

Novosibirsk State Medical University

ORCID: 0000-0003-3839-655X

Vorobjeva N.V.

Lomonosov Moscow State University

RSCI AuthorID: 95671
ORCID: 0000-0001-5233-9338

Received:

14.09.2021

Accepted:

11.11.2021

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References:

Cornblatt BA, Lenzenweger MF, Dworkin RH, Erlenmeyer-Kimling L. Positive and negative schizophrenic symptoms, attention, and information processing. Schizophr Bull. 1985;11(3):397-408. https://doi.org/10.1093/schbul/11.3.397
Frangou S, Sharma T, Alarcon G, et al. The Maudsley Family Study, II: Endogenous event-related potentials in familial schizophrenia. Schizophr Res. 1997;23(1):45-53. https://doi.org/10.1016/S0920-9964(96)00089-8
Galaverna FS, Morra CA, Bueno AM. Attention in patients with chronic schizophrenia: Deficit in inhibitory control and positive symptoms. Eur J Psychiat. [Internet]. 2012 Sep [cited 2021 Aug 16];26(3):185-195. https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0213-61632012000300005&lng=en. https://doi.org/10.4321/S0213-61632012000300005
Harvey PD, Koren D, Reichenberg A, Bowie CR. Negative symptoms and cognitive deficits: what is the nature of their relationship? Schizophr Bull. 2006;32(2):250-258. https://doi.org/10.1093/schbul/sbj011
Vanes LD, Mouchlianitis E, Patel K, et al. Neural correlates of positive and negative symptoms through the illness course: an fMRI study in early psychosis and chronic schizophrenia. Sci Rep. 2019;9(1):14444. Published 2019 Oct 8. https://doi.org/10.1038/s41598-019-51023-0
Posner MI, Petersen SE. The attention system of the human brain. Annu Rev Neurosci. 1990;13:25-42. https://doi.org/10.1146/annurev.ne.13.030190.000325
Fan J, McCandliss BD, Sommer T, Raz A, Posner MI. Testing the efficiency and independence of attentional networks. J Cogn Neurosci. 2002;14(3):340-347. https://doi.org/10.1162/089892902317361886
Wang K, Fan J, Dong Y, Wang CQ, Lee TM, Posner MI. Selective impairment of attentional networks of orienting and executive control in schizophrenia. Schizophr Res. 2005;78(2-3):235-241. https://doi.org/10.1016/j.schres.2005.01.019
Orellana G, Slachevsky A, Peña M. Executive attention impairment in first-episode schizophrenia. BMC Psychiatry. 2012;12:154. Published 2012 Sep 22. https://doi.org/10.1186/1471-244X-12-154
Nestor PG, Kubicki M, Spencer KM, Niznikiewicz M, McCarley RW, Shenton ME. Attentional networks and cingulum bundle in chronic schizophrenia. Schizophr Res. 2007;90(1-3):308-315. https://doi.org/10.1016/j.schres.2006.10.005
Neuhaus AH, Urbanek C, Opgen-Rhein C, et al. Event-related potentials associated with Attention Network Test. Int J Psychophysiol. 2010;76(2):72-79. https://doi.org/10.1016/j.ijpsycho.2010.02.005
Frith CD. The positive and negative symptoms of schizophrenia reflect impairments in the perception and initiation of action. Psychol Med. 1987;17(3):631-648. https://doi.org/10.1017/s0033291700025873
Lijffijt M, Lane SD, Meier SL, et al. P50, N100, and P200 sensory gating: relationships with behavioral inhibition, attention, and working memory. Psychophysiology. 2009;46(5):1059-1068. https://doi.org/10.1111/j.1469-8986.2009.00845.x
Laurent A, Garcia-Larréa L, d’Amato T, et al. Auditory event-related potentials and clinical scores in unmedicated schizophrenic patients. Psychiatry Res. 1999;86(3):229-238. https://doi.org/10.1016/s0165-1781(99)00038-4
Kaufman DA, Sozda CN, Dotson VM, Perlstein WM. An Event-Related Potential Investigation of the Effects of Age on Alerting, Orienting, and Executive Function. Front Aging Neurosci. 2016;8:99. Published 2016 May 9. https://doi.org/10.3389/fnagi.2016.00099
Simons CJ, Sambeth A, Krabbendam L, Pfeifer S, van Os J, Riedel WJ. Auditory P300 and N100 components as intermediate phenotypes for psychotic disorder: familial liability and reliability. Clin Neurophysiol. 2011;122(10):1984-1990. https://doi.org/10.1016/j.clinph.2011.02.033