The newer antipsychotic cariprazine (reagila): perspectives for use in different stages of schizophrenia therapy

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Cariprazine is a newer 3rd generation antipsychotic acting as partial agonist for dopamine receptors with unique higher affinity for D3 than D2 receptors. This review article summarizes key data from preclinical and clinical studies of cariprazine including pharmacodynamics, pharmacokinetics, clinical efficacy and safety/acceptability in acute short-term and long-term maintenance and relapse prevention therapy in patients with schizophrenia. Efficacy and safety of cariprazine in patients schizophrenia with predominantly negative symptoms resistant to previous antipsychotic therapy is discussed as well.

Keywords:

schizophrenia

positive disorders

negative disorders

therapy

antipsychotics

cariprazine

Authors:

Ivanov S.V.

Mental Health Research Center

ORCID: 0000-0001-9532-7150

Voronova E.I.

Sechenov First Moscow State Medical University (Sechenov University);
Mental Health Research Center

ORCID: 0000-0001-6605-4851

Received:

03.08.2021

Accepted:

06.08.2021

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