The relationship between visual dysfunction and cognitive deficit in schizophrenia

Karpinkaia V.Yu.; Tumova M.A.; Yanushko M.G.; Sosin D.N.; Maksimova A.A.; Ivanov M.V.

doi:https://doi.org/10.17116/jnevro202112108161

Karpinkaia V.Yu.

N. Bekhtereva Institute of the Human Brain Russian Academy of Sciences

Tumova M.A.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0002-3418-8596

Yanushko M.G.

Bekhterev National Research Medical Centre for Psychiatry and Neurology

Sosin D.N.

Russian Medical Academy of Continuing Professional Education

Maksimova A.A.

Pavlov St.-Petersburg State Medical University

Ivanov M.V.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0001-5851-0626

The relationship between visual dysfunction and cognitive deficit in schizophrenia

Authors:

Karpinkaia V.Yu., Tumova M.A., Yanushko M.G., Sosin D.N., Maksimova A.A., Ivanov M.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(8): 61‑66

DOI: 10.17116/jnevro202112108161

Read: 3499 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Karpinkaia VYu, Tumova MA, Yanushko MG, Sosin DN, Maksimova AA, Ivanov MV. The relationship between visual dysfunction and cognitive deficit in schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(8):61‑66. (In Russ.)
https://doi.org/10.17116/jnevro202112108161

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

Close metadata

OBJECTIVE

To investigate whether visual processing abnormalities are the result of visual dysfunction involving cognitive impairment or independent abnormalities and to identify the relationship of visual impairments with cognitive functions and severity of psychopathological symptoms.

MATERIAL AND METHODS

We compared results of visual size perception and actions on objects (motor assessment) in patients with schizophrenia (n=37), including patients with non-resistant schizophrenia (n=19) and healthy individuals (n=20). Cognitive impairments were assessed with BACS. Severity of schizophrenia symptoms was assessed with PANSS.

RESULTS

The error in the visual size perception test was smaller in healthy controls compared with non-resistant patients (p<0.03). There are no significant differences between non-resistant patients and other groups. Also, there are no significant differences in motor assessment between healthy controls and patients with schizophrenia. In the visual size perception test, the amount of error correlates with cognitive impairments (r= –0.84, p<0.001), and the severity of psychotic symptoms on PANSS (r=0.55, p<0.05).

CONCLUSION

Changes in visual threshold in patients with schizophrenia are correlated with cognitive dysfunction and reflect dysfunction in the parvocellular system.

Keywords:

schizophrenia

cognitive functions

verbal (visual) assessment

motor assessment

magnacellular system

parvocellular system

Authors:

Karpinkaia V.Yu.

N. Bekhtereva Institute of the Human Brain Russian Academy of Sciences

Tumova M.A.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0002-3418-8596

Yanushko M.G.

Bekhterev National Research Medical Centre for Psychiatry and Neurology

Sosin D.N.

Russian Medical Academy of Continuing Professional Education

Maksimova A.A.

Pavlov St.-Petersburg State Medical University

Ivanov M.V.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0001-5851-0626

Received:

10.11.2020

Accepted:

08.04.2021

Close metadata

References:

Linscott RJ, Allardyce J, van Os J. Seeking verisimilitude in a class: a systematic review of evidence that the criterial clinical symptoms of schizophrenia are taxonic. Schizophr Bull. 2010;36(4):811-829. https://doi.org/10.1093/schbul/sbn181
Ivanov MV, Tumova MA, Muslimova LM, Kapustina TV. Information processing deficits in patients with schizophrenia. Sibirskiy Vestnik Psikhiatrii i Narkologii. 2020;2(107):23-30. (In Russ.). https://doi.org/10.26617/1810-3111-2020-2(107)-41-50
Green MF, Lee J, Wynn JK, Mathis KI. Visual masking in schizophrenia: overview and theoretical implications. Schizophr Bull. 2011;37(4):700-708. https://doi.org/10.1093/schbul/sbr051
Simonova NA, Garakh ZhV, Zaytseva YuS, Shmukler AB. (2014). Neurophysiological mechanismsof impaired visual perception in schizophrenia. Sotsial’naya i Klinicheskaya Psikhiatriya. 2014;1(24):81-89. (In Russ.).
Laurens KR, Kiehl KA, Ngan ET, Liddle PF. Attention orienting dysfunction during salient novel stimulus processing in schizophrenia. Schizophr Res. 2005;75:159-171.
Nuechterlein KH, Barch DM, Gold JM, Goldberg TE, Green MF, Heaton RK. Identification of separable cognitive factors in schizophrenia. Schizophr Res. 2004;72(1):29-39. https://doi.org/10.1016/j.schres.2004.09.007
Silverstein SM, Bakshi S, Nuernberger S, Carpinello K, Wilkniss S. Effects of stimulus structure and target-distracter similarity on the development of visual memory representations in schizophrenia. Cogn Neuropsychiatry. 2005;10(3):215-229. https://doi.org/10.1080/13546800444000029
Hoff AL, Sakuma M, Razi K, Heydebrand G, Csernansky JG, DeLisi LE. Lack of association between duration of untreated illness and severity of cognitive and structural brain deficits at the first episode of schizophrenia. Am J Psychiatry. 2000;157(11):1824-1828. https://doi.org/10.1176/appi.ajp.157.11.1824
Green MF, Nuechterlein KH. Should schizophrenia be treated as a neurocognitive disorder? Schizophr Bull. 1999;25(2):309-319. https://doi.org/10.1093/oxfordjournals.schbul.a033380
Javitt DC, Liederman E, Cienfuegos A, Shelley AM. Panmodal processing imprecision as a basis for dysfunction of transient memory storage systems in schizophrenia. Schizophr Bull. 1999;25(4):763-775. https://doi.org/10.1093/oxfordjournals.schbul.a033417
Chang BP, Lenzenweger MF. Somatosensory processing in the biological relatives of schizophrenia patients: a signal detection analysis of two-point discrimination. J Abnorm Psychol. 2001;110(3):433-442. https://doi.org/10.1037//0021-843x.110.3.433
Marosi C, Fodor Z, Csukly G. From basic perception deficits to facial affect recognition impairments in schizophrenia. Sci Rep. 2019;9(1):8958. Published 2019 Jun 20. https://doi.org/10.1038/s41598-019-45231-x
Berkovitch L, Dehaene S, Gaillard R. Disruption of Conscious Access in Schizophrenia. Trends Cogn Sci. 2017;21(11):878-892. https://doi.org/10.1016/j.tics.2017.08.006
Gold JM, Fuller RL, Robinson BM, Braun EL, Luck SJ. Impaired top-down control of visual search in schizophrenia. Schizophr Res. 2007;94(1-3):148-155. https://doi.org/10.1016/j.schres.2007.04.023
Mishkin M, Ungerleider LG. Contribution of striate inputs to the visuospatial functions of parieto-preoccipital cortex in monkeys. Behav Brain Res. 1982;6(1):57-77. https://doi.org/10.1016/0166-4328(82)90081-x
Goodale MA, Milner AD. Separate visual pathways for perception and action. Trends Neurosci. 1992;15(1):20-25. https://doi.org/10.1016/0166-2236(92)90344-8
Goodale MA, Milner AD. Two visual pathways — Where have they taken us and where will they lead in future? Cortex. 2018;98:283-292. https://doi.org/10.1016/j.cortex.2017.12.002
Lehman AF, Lieberman JA, Dixon LB, McGlashan TH, Miller AL, Perkins DO, Kreyenbuhl J. Practice guideline for the treatment of patients with schizophrenia, second edition. Am J Psychiatry. 2004;161(2 suppl):1-56.
Bruno N, Franz VH. When is grasping affected by the Müller-Lyer illusion? A quantitative review. Neuropsychologia. 2009;47(6):1421-1433. https://doi.org/10.1016/j.neuropsychologia.2008.10.031
Karpinskaya VYu, Lyakhovetskiy VA. The differences in the sensorimotor estimation of the Ponzo and Müller-Lyer illusions. Psikhologicheskiye issledovaniya. 2014;7(38):3. (In Russ.). https://psystudy.ru
Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia. Schizophrenia Bulletin. 1987;2(13):261-276. https://doi.org/10.1093/schbul/13.2.261
Sarkisyan GR, Gurovich IYa, Keefe RS. Normative data for the russian population and standardization of The Brief assessment of cognition in schizophrenia (BACS) scale. Sotsial’naya i klinicheskaya psikhiatriya. 2010;3(20):13-19. (In Russ.).
Yeap S, Kelly SP, Sehatpour P, Magno E, Garavan H, Thakore JH, Foxe JJ. Visual sensory processing deficits in Schizophrenia and their relationship to disease state. Eur Arch Psychiatry Clin Neurosci. 2008;258(5):305-316. https://doi.org/10.1007/s00406-008-0802-2
Butler PD, Martinez A, Foxe JJ, Kim D, Zemon V, Silipo G, Mahoney J, Shpaner M, Jalbrzikowski M, Javitt DC. Subcortical visual dysfunction in schizophrenia drives secondary cortical impairments. Brain. 2007;130(Pt 2):417-430. https://doi.org/10.1093/brain/awl233
Herzog MH, Roinishvili M, Chkonia E, Brand A. Schizophrenia and visual backward masking: a general deficit of target enhancement. Front Psychol. 2013;4:254. Published 2013 May 14. https://doi.org/10.3389/fpsyg.2013.00254
Foxe JJ, Murray MM, Javitt DC. Filling-in in schizophrenia: a high-density electrical mapping and source-analysis investigation of illusory contour processing. Cereb Cortex. 2005;15(12):1914-1927. https://doi.org/10.1093/cercor/bhi069
Plomp G, Roinishvili M, Chkonia E, Kapanadze G, Kereselidze M, Brand A, Herzog MH. Electrophysiological evidence for ventral stream deficits in schizophrenia patients. Schizophr Bull. 2013;39(3):547-554. https://doi.org/10.1093/schbul/sbr175
Qiu L, Tian L, Pan C, Zhu R, Liu Q, Yan J, Zhao Q, Yuan H, Han Y, Yue W, Yan H, Zhang D. Neuroanatomical circuitry associated with exploratory eye movement in schizophrenia: a voxel-based morphometric study. PLoS One. 2011;6(10):e25805. https://doi.org/10.1371/journal.pone.0025805
Kudryashova VYu, Lutova NB. The role of self-regulation of behavior as an aspect of adaptive-compensatory mechanisms in patients with paranoid schizophrenia. Obozreniye Psikhiatrii i Meditsinskoy Psikhologii. 2019;1:26-33. (In Russ.). https://doi.org/10.31363/2313-7053-2019-1-26-33