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Yakupov E.Z.

Scientific Research Medical Complex «Your Health»;
Kazan State Medical University

Troshina Y.V.

Scientific Research Medical Complex «Your Health»;
Kazan State Medical University

Gainutdinova R.R.

Scientific Research Medical Complex «Your Health»

Kashapova A.O.

Scientific Research Medical Complex «Your Health»

Evaluation of the efficacy and safety of the neuroprotective complex Neurouridin in patients with back pain

Authors:

Yakupov E.Z., Troshina Y.V., Gainutdinova R.R., Kashapova A.O.

More about the authors

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To cite this article:

Yakupov EZ, Troshina YV, Gainutdinova RR, Kashapova AO. Evaluation of the efficacy and safety of the neuroprotective complex Neurouridin in patients with back pain. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(6):46‑51. (In Russ.)
https://doi.org/10.17116/jnevro202112106146

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References:

  1. Yakupov EZ. Adjuvant therapy of pain syndromes: possibilities of using nucleotides. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2019;119(10):141-145. (In Russ.). https://doi.org/10.17116/jnevro2019119101141
  2. Yakupov EZ. Treatment of the pain syndroms.New look at the old problem? Medical Sovet. 2019;12:50-54. (In Russ.).
  3. Goldberg H, Mibielli MA, Nunes CP, et al. A double-blind, randomized, comparative study of the use of a combination of uridine triphosphate trisodium, cytidine monophosphate disodium, and hydroxocobalamin, versus isolated treatment with hydroxocobalamin, in patients presenting with compressive neuralgias. J Pain Res. 2017;10:397-404.  https://doi.org/10.2147/JPR.S123045
  4. Palomo-Guerrero M, Cosgaya JM, Gella A, Casals N, Grjiota-Martinez C. Uridine-5’-triphosphate partially blocks differentiation signals and favors a more repair state in cultured rat Schwann cells. Neuroscience. 2018;372:255-265.  https://doi.org/10.1016/j.neuroscience.2018.01.010
  5. Kukushkin ML, Reshetnyk VK. Purynergic mechanisms of pain and analgesia. Russian Journal of Pain. 2019;17(1):51-56. (In Russ.). https://doi.org/10.25731/RASP.2019.01.09
  6. Lamarca A, Gella A, Martiañez T, Segura M, Figueiro-Silva J, Grijota-Martinez C, Trullas R, Casals N. Uridine-5-triphosphate promotes in vitro schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014;9(6):e98998. https://doi.org/10.1371/journal.pone.0098998
  7. Ford AP. In pursuit of P2X3 antagonists: Novel therapeutics for chronic pain and afferent sensitization. Purinergic Signalling. 2012;8:3-26. 
  8. Ahlawat A, Sharma S. A new promising simultaneous approach for attenuating type II diabetes mellitus induced neuropathic pain in rats: iNOS inhibition and neuroregeneration. Eur J Pharmacol. 2018;818:419-428.  https://doi.org/10.1016/j.ejphar.2017.11.010
  9. Negrão L, Almeida P, Alcino S, Libório T, Silva UM, Figueira R, Gonçalves S, Parra LN. Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies. Pain Manag. 2014;4(3):191-196.  https://doi.org/10.2217/pmt.14.10
  10. Trippe BS, Barrentine LW, Curole MV, Tipa E. Nutritional management of patients with diabetic peripheral neuropathy with Metanx: results of a real-world patient experience trial. Curr Med Res Opin. 2016;32(2):219-227.  https://doi.org/10.1185/03007995.2015.1103215
  11. Mibielli MA, Nunes CP, Scussel Jr AB. Symptomatic improvement in an acute, non-traumatic spine pain model with a combination of uridine triphosphate, cytidine monophosphate, and hydroxocobalamin. Pain Studies and Treatment. 2014;2(1):6-10.  https://doi.org/10.4236/pst.2014.21002
  12. Sloan G, Shillo P, Selvarajah D, Jing Wu, Wilkinson ID, Tracey I, Anand P, Tesfaye S. A new look at painful diabetic neuropathy. Diabetes Res Clin Pract. 2018. pii: S0168-8227(18)31192-6.  https://doi.org/10.1016/j.diabres.2018.08.020
  13. Yakupov EZ, Troshina JV, Kashapova AO, Nasrieva AM, Chigg RS. Results of observational study in the Russian Federation of the efficacy and safety of high doses of supplement «Neurouridine» (combination of uridine monophosphate (150 mg) with choline) in the treatment of patients with nonspecific low back pain. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2020;120(9):53-59. (In Russ.). https://doi.org/10.17116/jnevro202012009153

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