Comparative chemoreactome analysis of the synergism of vinpocetine, piracetam, and cinnarizine molecules

Gromova O.A.; Torshin I.Yu.

doi:https://doi.org/10.17116/jnevro202112112169

Gromova O.A.

Federal Research Center «Computer Science and Control»

ORCID: 0000-0002-7663-710X

Torshin I.Yu.

Federal Research Center «Computer Science and Control»

ORCID: 0000-0002-2659-7998

Comparative chemoreactome analysis of the synergism of vinpocetine, piracetam, and cinnarizine molecules

Authors:

Gromova O.A., Torshin I.Yu.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(12): 69‑76

DOI: 10.17116/jnevro202112112169

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To cite this article:

Gromova OA, Torshin IYu. Comparative chemoreactome analysis of the synergism of vinpocetine, piracetam, and cinnarizine molecules. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(12):69‑76. (In Russ.)
https://doi.org/10.17116/jnevro202112112169

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

Neuroprotective and nootropic drugs often exhibit complementary, «synergistic» effects, the consideration of which is important for choosing the most effective and safe drug combinations.

MATERIAL AND METHODS

Chemoinformatic analysis of vinpocetine, piracetam and cinnarizine on neuron cultures, on model organisms (mice, rats) based on modern data mining and machine learning methods.

RESULTS

The paper presents the results of the chemoreactom analysis of vinpocetine, piracetam, and cinnarizine. Estimates of various biological activities of molecules on neuronal cultures, on model organisms (mice, rats) and estimates of modulation of the activity of target proteins in rats and humans were obtained. The data obtained made it possible to quantify the value of the synergism score for the combination «vinpocetine + piracetam» (54 points) compared with the combination «piracetam + cinnarizine» (25 points).

CONCLUSIONS

The combination of «vinpocetine + piracetam» in the fixed combination (Vinpotropil) is thus more preferable for combined use than for the combination of «piracetam + cinnarizine».

Keywords:

combination therapy

neuroprotection

chemoinformatics

synergism

Vinpotropil

vinpocetine

piracetam

cinnarizine

data mining

Authors:

Gromova O.A.

Federal Research Center «Computer Science and Control»

ORCID: 0000-0002-7663-710X

Torshin I.Yu.

Federal Research Center «Computer Science and Control»

ORCID: 0000-0002-2659-7998

Received:

16.08.2021

Accepted:

28.08.2021

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References:

Zhang YS, Li JD, Yan C. An update on vinpocetine: New discoveries and clinical implications. Eur J Pharmacol. 2018;819:30-34. https://doi.org/10.1016/j.ejphar.2017.11.041
Svab G, Doczi J, Gerencser AA, Ambrus A, Gallyas F, Sümegi B, Tretter L. The Mitochondrial Targets of Neuroprotective Drug Vinpocetine on Primary Neuron Cultures, Brain Capillary Endothelial Cells, Synaptosomes, and Brain Mitochondria. Neurochem Res. 2019;44(10):2435-2447. https://doi.org/10.1007/s11064-019-02871-9
Zhang C, Hsu CG, Mohan A, Shi H, Li D, Yan C. Vinpocetine protects against the development of experimental abdominal aortic aneurysms. ClinSci (Lond). 2020;134(22):2959-2976. https://doi.org/10.1042/CS20201057
Gouliaev AH, Senning A. Piracetam and other structurally related nootropics. Brain Research. Brain Research Reviews. 1994;19(2):180-222.
Pimenov LT, Kalinina SA, Churshin AD. Clinical and hemodynamic efficacy of piracetam (nootropil) in elderly and senile patients with ischemic heart disease at the outpatient rehabilitation stage. Cardiology. 1992;5:35-38. (In Russ.).
Niss AI, Umansky KG. On the effectiveness of treatment with piracetam for acute viral neuroinfections. Journal Neuropathology and Psychiatry named after S.S. Korsakov. 1985;2:189-195. (In Russ.).
Pimenov LT, Churshin AD, Ezhov AV. On the ability of piracetam and tocopherol acetate to potentiate the clinical efficacy of antianginal drugs in patients with coronary heart disease. Clinical Medicine. 1997;1:32-35. (In Russ.).
Avedisova AS, Akhapkin RV, Akhapkina VI, Verigo NN. Piracetam in modern research (analysis of foreign studies). Psychiatry and psychopharmacotherapy. 2000;2:6:178-184. (In Russ.).
Chetly E. Stimulants of the central nervous system, Problem drugs. Per. from English. Riga, Latvia: Landmark; 1998. (In Russ.).
Mashkovsky MD. Medicines. 16th ed. revised, revised and add. M.: New Wave; 2019. (In Russ.).
Mikhailov IB. Clinical pharmacology. SPb.: Foliant; 1998. (In Russ.).
Haress NG. Cinnarizine: Comprehensive Profile. Profiles Drug Subst Excip Relat Methodol. 2015;40:1-41. Epub 2015 Apr 1. PMID: 26051684. https://doi.org/10.1016/bs.podrm.2015.01.001
Torshin IU, Gromova OA, Mayorova LA, et al. Chemoreactom analysis of cytidyldiphosphocholine indicates synergistic combinations of neuroprotective agents. Neurology, neuropsychiatry, psychosomatics. 2021;13(2):144-156. (In Russ.). https://doi.org/10.14412/2074-2711-2021-2-144-156
Gromova OA, Torshin IYu, Grishina TR, Demidov VI, Bogacheva TE. Molecular and clinical aspects of the effect of cytidine diphosphocholine on cognitive function. Journal of Neurology and Psychiatry S.S. Korsakov. 2021;121(5):81-90. (In Russ.). https://doi.org/10.17116/jnevro202112105188
Gromova OA, Torshin IYu, Putilina MV, Stakhovskaya LV, Rudakov KV. Chemoreactom analysis of the central mechanisms of non-steroidal anti-inflammatory drugs. Journal of Neurology and Psychiatry S.S. Korsakov. 2020;120(1):70-77. (In Russ.). https://doi.org/10.17116/jnevro202012001170
Torshin IYu, Gromova OA, Stakhovskaya LV, Semenov VA, Gromov AN. Differential chemoreactome analysis of synergistic combinations of tolperisone and nonsteroidal anti-inflammatory drugs. Neurology, Neuropsychiatry, Psychosomatics. 2019;11(2):78-85. (In Russ.). https://doi.org/10.14412/2074-2711-2019-2-78-85