The effect of various forms of folates on cognitive functions in patients with chronic schizophrenia

Zhilyaeva T.V.; Blagonravova A.S.; Mazo G.E.

doi:https://doi.org/10.17116/jnevro202012009187

Zhilyaeva T.V.

Privolzhsky Research Medical University

Blagonravova A.S.

Privolzhsky Research Medical University

Mazo G.E.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0001-7910-9129

The effect of various forms of folates on cognitive functions in patients with chronic schizophrenia

Authors:

Zhilyaeva T.V., Blagonravova A.S., Mazo G.E.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(9): 87‑92

DOI: 10.17116/jnevro202012009187

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To cite this article:

Zhilyaeva TV, Blagonravova AS, Mazo GE. The effect of various forms of folates on cognitive functions in patients with chronic schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(9):87‑92. (In Russ.)
https://doi.org/10.17116/jnevro202012009187

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

OBJECTIVE

To assess the dynamics of cognitive functions in patients with schizophrenia during intake of various forms of folate as an add-on to antipsychotic therapy.

MATERIAL AND METHODS

Using a battery of cognitive tests, the authors evaluated the dynamics of cognitive functions in 3 groups of patients with schizophrenia who received folic acid (n=25), metafolin (n=25) during 4 weeks and in the control group (n=25). Genetic variants of the polymorphism of the folate metabolism enzyme methylenetetrahydrofolate reductase (MTHFR) 677C>T were determined using real-time PCR. Only the carriers of the minor T allele were included in the study.

RESULTS AND CONCLUSION

The improvement of certain cognitive functions was noted after folate administration, it was more pronounced and statistically significant in the metapholin group. The results hold promises for further studies of prolonged use of folate in prophylactic doses for schizophrenia.

Keywords:

folates

schizophrenia

single nucleotide polymorphism MTHFR 677 C>T

cognitive impairment

Authors:

Zhilyaeva T.V.

Privolzhsky Research Medical University

Blagonravova A.S.

Privolzhsky Research Medical University

Mazo G.E.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0001-7910-9129

Received:

21.01.2020

Accepted:

08.04.2020

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References:

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