The role of saturated fatty acids in impaired lipid metabolism in patients with alcohol dependence syndrome

Solovieva V.A.; Leichter S.N.; Solovieva N.V.; Bichkaeva F.A.; Ishekov N.S.; Soloviev A.G.

doi:https://doi.org/10.17116/jnevro202012009193

Solovieva V.A.

Lomonosov Northern (Arctic) Federal University

Leichter S.N.

Northern State Medical University

Solovieva N.V.

Scientific Center of Personalized Medicine

Bichkaeva F.A.

Institute of Physiology of Natural Adaptations

Ishekov N.S.

Lomonosov Northern (Arctic) Federal University

Soloviev A.G.

Northern State Medical University

SPIN RSCI: 2952-0619
Scopus AuthorID: 7103242976
ORCID: 0000-0002-0350-1359

The role of saturated fatty acids in impaired lipid metabolism in patients with alcohol dependence syndrome

Authors:

Solovieva V.A., Leichter S.N., Solovieva N.V., Bichkaeva F.A., Ishekov N.S., Soloviev A.G.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(9): 93‑97

DOI: 10.17116/jnevro202012009193

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To cite this article:

Solovieva VA, Leichter SN, Solovieva NV, Bichkaeva FA, Ishekov NS, Soloviev AG. The role of saturated fatty acids in impaired lipid metabolism in patients with alcohol dependence syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(9):93‑97. (In Russ.)
https://doi.org/10.17116/jnevro202012009193

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To determine the content and role of saturated fatty acids (SFA) in lipid metabolism disorder in patients with alcohol dependence syndrome (ADS).

MATERIAL AND METHODS

A total of 123 men were examined: 44 patients with ADS and 79 healthy people. The patients were examined on the 5—6 day after admission to the hospital. The content of saturated fatty acids (SFA) (caproic, caprylic, capric, undecyl, lauric, tridecane, myristic, pentadecanoic, palmitic, margarine, stearic, arachin, eicosanoic, behenic) was determined by gas-liquid chromatography. Quantitative calculation of SFA levels was carried out by the AgilentChemStationB.03.01 program (USA). The ratio of stearic to palmitic acid (C18:0/C16:0) was calculated. The study of the enzymatic activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyltransferase (GGT) was carried out by generally accepted standardized methods on a Cobas Mirra automated analyzer.

RESULTS

In ADS patients, changes in the composition of SFA were found with an increase in the number of short-chain fatty acids (caproic acid by 52.2%, caprylic acid by 75.5%); medium-chain acids (capric acid by 47.9%, undecyl acid by 74.7%, lauric acid), but with a decrease in the concentration of long-chain acids (pentadecanoic by 5.1%, margarine by 34.7%, arachinic by 19.58%, eicosanoic by 26.6%, behenic by 5.1%). Less correlations between the fatty acid content and the parameters of the lipid transport system of blood serum were established in ADS patients compared to the controls. This indicates deep disorders of lipid metabolism.

CONCLUSION

The results expand the understanding of the complex mechanisms of lipid metabolism disorders in ASD, which is important for secondary prevention. They also substantiate the need for a purposeful study of lipid metabolism disorders in patients with ADS at an earlier stage of the disease.

Keywords:

alcohol dependence syndrome

saturated fatty acids

lipid metabolism disorders

Authors:

Solovieva V.A.

Lomonosov Northern (Arctic) Federal University

Leichter S.N.

Northern State Medical University

Solovieva N.V.

Scientific Center of Personalized Medicine

Bichkaeva F.A.

Institute of Physiology of Natural Adaptations

Ishekov N.S.

Lomonosov Northern (Arctic) Federal University

Soloviev A.G.

Northern State Medical University

SPIN RSCI: 2952-0619
Scopus AuthorID: 7103242976
ORCID: 0000-0002-0350-1359

Received:

15.04.2020

Accepted:

16.04.2020

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