Asthenic disorders. History and modernity

Chutko L.S.; Surushkina S.Yu.

doi:https://doi.org/10.17116/jnevro2020120061131

Close metadata

Recommended articles:

Current aspects of the relationship between depression and cognitive impairment in patients with Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(10):66-74

Results of the observational program CITOTREK (use of the drug CITOflavin in Tablets) in patients with tension headaches against the backgRound of asthenic syndromE taKing into account comorbidity. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(10):104-112

Cogitum in the treatment of mental disorders in childhood. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(10-2):88-95

Search for risk factors for slowed intra-atrial conduction in patients with schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(11):111-116

Study of the role of interleukin-1β in blood serum in patients with acne. Russian Journal of Clinical Dermatology and Venereology. 2025;(4):421-424

Mitochondrial cytoprotectors in complex therapy of chronic heart failure in patients with metabolic syndrome or type 2 diabetes mellitus: subanalysis of the INDIKOR study. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(5):566-576

Community-acquired pneumonia in adults. Clinical guidelines 2024 (short version). Journal of Respiratory Medicine. 2025;(3):6-18

Pulmonary heart: definition, classification, pathogenesis, diagnostics. Morphologist’s view. Journal of Respiratory Medicine. 2025;(3):60-64

Analytical review of the pathophysiological mechanisms of ischemia-reperfusion syndrome development in PCI. Russian Journal of Anesthesiology and Reanimatology. 2025;(5):88-97

Endometriosis-associated infertility and the efficacy of dienogest. Russian Journal of Human Reproduction. 2025;(5):58-63

Abstract:

The article presents a review of publications devoted to asthenic disorders. The authors consider the various views on the etiology and basic mechanisms of the pathogenesis of asthenia and features of clinical manifestations of various diseases with asthenia as a key syndrome, as well as modern approaches to the treatment of these disorders.

Keywords:

asthenia

etiology

pathogenesis

therapy

Authors:

Chutko L.S.

N. Bekhtereva Institute of Human Brain Russian Academy of Sciences

SPIN RSCI: 8414-1893
Scopus AuthorID: 6507009385
ORCID: 0000-0002-1065-9859

Surushkina S.Yu.

N. Bekhtereva Institute of Human Brain Russian Academy of Sciences

SPIN RSCI: 2823-4890
Scopus AuthorID: 35771705500
ORCID: 0000-0001-9510-7182

Received:

14.04.2020

Accepted:

15.04.2020

Close metadata

References:

Aleksandrovskii YuA. Pogranichnye psikhicheskie rasstroistva. M. 2000. (In Russ).
Bamdas BS. Astenicheskie sostoyaniya. M. 1961. (In Russ).
Beard GM. Neurasthenia, or Nervous Exhaustion. Boston Med Surg J. 1869;80:217-222. https://doi.org/10.1056/nejm186904290801301
Belitskii Yu. Nevrasteniya. Ee sushchnost’, prichiny, simptomy, vidy i lechenie. SPb. 1906. (In Russ).
Kennaway J. Stimulating Music: The Pleasures and Dangers of «Electric Music», 1750—1900. Configurations. 2011;19(2):191-211. https://doi.org/10.1353/con.2011.0018
Price RK, North CS, Wessely S, Fraser VJ. Estimating the prevalence of chronic fatigue syndrome and associated symptoms in the community. Public Health Rep. 1992;107(5):514-522.
Hickie I, Da Venport T, Issakidis C, Andrews G. Neurasthenia: prevalence, disability and health care characteristics in the Australian community. British Journal of Psychiatry. 2002;181:56-61. https://doi.org/10.1192/bjp.181.1.56
Skapinakis P, Lewis G, Mavreas V. Temporal relation between unexplained fatigue and depression: longitudinal data from an international study in primary care. Psychosom Med. 2004;66(3):330-335. https://doi.org/10.1097/01.psy.0000124757.10167.b1
Watanabe N, Stewart R, Jenkins R, Bhugra DK, Furukawa TA. The epidemiology of chronic fatigue, physical illness, and symptoms of common mental disorders: a cross-sectional survey from the second British National Survey of Psychiatric Morbidity. J Psychosom Res. 2008;64(4):357-362. https://doi.org/10.1016/j.jpsychores.2007.12.003
Akarachkova ES. Chronic fatigue syndrome and an approach to its treatment. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2010;1(2):48-54. (In Russ).
Kreindler A. Astenicheskii nevroz. Per. s rum. Bukharest. 1963. (In Russ).
Polozhii BS. Psikhicheskoe zdorov’e i sotsial’noe sostoyanie obshchestva. Sotsiokul’tural’nye problemy sovremennoi psikhiatrii. Materialy VIII nauchnyh Kerbikovskih chtenij. M. 1994;88-94. (In Russ).
Myasishchev VN. Lichnost’ i nevrozy. Monografiya. Izdatel’stvo Leningradskogo Universiteta; 1960. (In Russ).
Svyadoshch AM. Nevrozy. Ruk-vo dlya vrachei. SPb.: Piter; 1997. (In Russ).
Stubhaug B, Tveito TH, Eriksen HR, Ursin H. Neurasthenia, subjective health complaints and sensitization. Psychoneuroendocrinology. 2005;30(10):1003-1009. https://doi.org/10.1016/j.psyneuen.2005.04.011
Smulevich AB. Pogranichnye psikhicheskie narusheniya. Rukovodstvo po psikhiatrii. M. 1999. (In Russ).
Vasil’eva AV, Karavaeva TA, Poltorak SV. Lingering forms of neurotic disorders: clinical-psychopathological aspects and therapy issues. Obozrenie Psikhiatrii i Meditsinskoi Psikhologii. 2012;4:81-87 (In Russ).
Afari N, Buchwald D. Chronic fatigue syndrome: a review. Am J Psychiatry. 2003;160:221-236. https://doi.org/10.1176/appi.ajp.160.2.221
Bested AC, Marshall LM. Review of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: an evidence-based approach to diagnosis and management by clinicians. Rev Environ Health. 2015;30(4):223-249. https://doi.org/10.1515/reveh-2015-0026
White PD. What causes chronic fatigue syndrome? BMJ. 2004;329(7472):928-929. https://doi.org/10.1136/bmj.329.7472.928
Underhill RA. Myalgic encephalomyelitis, chronic fatigue syndrome: An infectious disease. Med Hypotheses. 2015;85(6):765-773. https://doi.org/10.1016/j.mehy.2015.10.011
Van Houdenhove B, Kempke S, Luyten P. Psychiatric Aspects of Chronic Fatigue Syndrome and Fibromyalgia. Current Psychiatry. 2010;12(3):208-214. https://doi.org/10.1007/s11920-010-0105-y
Rollnik JD. Chronic Fatigue Syndrome: A Critical Review. Fortschr Neurol Psychiatr. 2017;85(2):79-85. https://doi.org/10.1055/s-0042-121259
Słomko J, Newton JL, Kujawski S, Tafil-Klawe M, Klawe J, Staines D, Marshall-Gradisnik S, Zalewski P. Prevalence and characteristics of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in Poland: a cross-sectional study. BMJ Open. 2019;9(3):e023955. https://doi.org/10.1136/bmjopen-2018-023955
Johnston SC, Staines DR, Marshall-Gradisnik SM. Epidemiological characteristics of chronic fatigue syndrome/myalgic encephalomyelitis in Australian patients. Clin Epidemiol. 2016;8:97-107. https://doi.org/10.2147/CLEP.S96797
Owe JF, Næss H, Gjerde IO, Bødtker JE, Tysnes OB. Investigation of suspected chronic fatigue syndrome/myalgic encephalopathy. Tidsskr Nor Laegeforen. 2016;136(3):227-232. https://doi.org/10.4045/tidsskr.15.0229
Wessely S. Chronic fatigue syndrome. British Journal of Psychiatry. 1990;157(3):447-448. https://doi.org/10.1192/bjp.157.3.447
Overholser J, Beale E. Neurasthenia. The Journal of Nervous and Mental Disease. 2019;207(9):731-739. https://doi.org/10.1097/nmd.0000000000000943
Galvez-Sánchez CM, Duschek S, Reyes Del Paso GA. Psychological impact of fibromyalgia: current perspectives. Psychol Res Behav Manag. 2019;12:117-127. https://doi.org/10.2147/PRBM.S178240
Fukuda K. The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study. Annals of Internal Medicine. 1994;121(12):953. https://doi.org/10.7326/0003-4819-121-12-199412150-00009
Fedin AI, Solov’eva ÉIu, Mironova OP, Fedotova AV. Treatment of asthenic syndrome in patients with chronic brain ischemia: results of the non-interventional observational program TRIUMPH. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2014;114(12):104-111. (In Russ). https://doi.org/10.17116/jnevro2014114121104-111
Kadykov AS, Shakhparonova NV, Kashina EM. Astenic conditions in the clinic of vascular diseases of the brain and the possibility of their correction. Nervnye bolezni. 2012;1:24-28. (In Russ).
Bogousslavsky J. William Feinberg Lecture 2002: emotions, mood and behavior after stroke. Stroke. 2003;34:1046-1050. https://doi.org/10.1161/01.str.0000061887.33505.b9
Acciarresi M, Bogousslavsky J, Paciaroni M. Post-Stroke Fatigue: Epidemiology, Clinical Characteristics and Treatment. European Neurology. 2014;72(5-6):255-261. https://doi.org/10.1159/000363763
van Rooij FG, Plaizier NO, Vermeer SE, Góraj BM, Koudstaal PJ, Richard E, de Leeuw FE, Kessels RPC, van Dijk EJ. Subjective Cognitive Impairment, Depressive Symptoms, and Fatigue after a TIA or Transient Neurological Attack: A Prospective Study. Behav Neurol. 2017;5181024. https://doi.org/10.1155/2017/5181024
Solov’eva SL, Uspenskii YuP, Fominykh YuA. Ponyatie astenii v klinike vnutrennikh boleznei. Astenicheskie rasstroistva v terapevticheskoi praktike. Rukovodstvo po diagnostike i lecheniyu. Pod. red. Shabrova A.V., Solov’evoi S.L. SPb. 2010. (In Russ).
Bushnik T, Englander J, Wright J. Patterns of fatigue and its correlates over the first 2 years after traumatic brain injury. J Head Trauma Rehabil. 2008;23(1):25-32. https://doi.org/10.1097/01.htr.0000308718.88214.bb
Cantor JB, Ashman T, Gordon W, Ginsberg A, Engmann C, Egan M, Spielman L, Dijkers M, Flanagan S. Fatigue after traumatic brain injury and its impact on participation and quality of life. J Head Trauma Rehabil. 2008;23(1):41-51. https://doi.org/10.1097/01.htr.0000308720.70288.af
Wylie GR, Dobryakova E, DeLuca J, Chiaravalloti N, Essad K, Genova H. Cognitive fatigue in individuals with traumatic brain injury is associated with caudate activation. Sci Rep. 2017;7(1):89-73. https://doi.org/10.1038/s41598-017-08846-6
Beaulieu-Bonneau S, Morin CM. Sleepiness and fatigue following traumatic brain injury. Sleep Med. 2012;13(6):598-605. https://doi.org/10.1016/j.sleep.2012.02.010
Ponsford JL, Hsieh M. Psychological Interventions for Emotional and Behavioral Problems Following Traumatic Brain Injury. In: Zasler N.D., Katz D.I. eds Brain Injury Medicine. Principles and Practice, 2nd Edition; 2012. https://doi.org/10.1891/9781617050572.0064
Boni J, Maugeri A, Zingali G, Ramelli L, Gherardi S. Steady-state pharmacokinetics of idebenone in healthy volunteers. Archives of Gerontology and Geriatrics. 1992;15:3:197-205. https://doi.org/10.1016/0167-4943(92)90055-9
Rachin AP, Averchenkova AA. Idebenone (noben) — from theory to practice. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2011;111(5):81-84. (In Russ).
Damulin IV. The use of idebenone (noben) in neurological practice. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2006;106:66-71. (In Russ).
Takuma K, Yoshida T, Lee E, Mori K, Kishi T, Baba A, Matsuda T. CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production. Eur J Pharmacol. 2000;406:333-339. https://doi.org/10.1016/s0014-2999(00)00701-9
Cardoso SM, Pereira C, Oliveira CR. The protective effect of vitamin E, idebenone and reduced glutathione on free radical mediated injury in rat brain synaptosomes. Biochem Biophys Res Commun. 1998;246:703-710. https://doi.org/10.1006/bbrc.1998.8563
Marigliano V, Abate G, Barbagallo-Sangiorgi G, Bartorelli L, Capurso A, Cucinotta D, Cuzzupoli M, Senin U, Tammaro AE, Fioravanti M. Randomized, double-blind, placebo controlled, multicentre study of idebenone in patients suffering from multi-infarct dementia. Arch Gerontol Geriat. 1992;15:239-248. https://doi.org/10.1016/0167-4943(92)90059-d
Bergamasco B, Villardita C, Coppi R. Idebenone in the treatment of multi-infarct dementia: a randomised, double-blind, placebo controlled multicentre trial. Arch Gerontol Geriatr. 1992;15:271-278. https://doi.org/10.1016/0167-4943(92)90062-9
Muzychenko AP, Krasnoslobodtseva LA. Deistvie Nobena pri organicheskom emotsional’no-labil’nom (astenicheskom) rasstroistve: klinicheskie i neirofiziologicheskie aspekty. Klinicheskaya farmakologiya. 2008;1:2-5. (In Russ).
Voronkova KV, Meleshkov MN. Noben (idebenone) in the treatment of dementia and memory impairment without dementia. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2008;108:4:27-32. (In Russ).
Boiko AN, Lebedeva AV, Shchukin IA, Soldatov MA, Petrov SV, Khozova AA, Ismailov AM, Shikhkerimov RK. Emotsional’nye rasstroistva i kachestvo zhizni u patsientov s postinsul’tnoi asteniei. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2013;11:27-33. (In Russ).
Slizkova YuB. Experience of application of noben in the treatment of post-communication syndrome in patients after a light cranio-brain injury. Nervnye Bolezni. 2007;2:22-26. (In Russ).