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Brusov O.S.

Mental Health Research Center

Oleĭchik I.V.

Mental Health Research Centre

Karpova N.S.

Mental Health Research Center

Faktor M.I.

Mental Health Research Center

Sizov S.V.

Mental Health Research Center

Correlations between thrombodynamic parameters of coagulation and negative syndromes in patients with schizophrenia

Authors:

Brusov O.S., Oleĭchik I.V., Karpova N.S., Faktor M.I., Sizov S.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(12): 86‑91

DOI: 10.17116/jnevro202012012186

Read: 1377 times

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Table of contents

CORRELATIONS BETWEEN THROMBODYNAMIC PARAMETERS OF COAGULATION AND NEGATIVE SYNDROMES IN PATIENTS WITH SCHIZOPHRENIA
CORRELATIONS BETWEEN THROMBODYNAMIC PARAMETERS OF COAGULATION AND NEGATIVE SYNDROMES IN PATIENTS WITH SCHIZOPHRENIA

To cite this article:

Brusov OS, Oleĭchik IV, Karpova NS, Faktor MI, Sizov SV. Correlations between thrombodynamic parameters of coagulation and negative syndromes in patients with schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(12):86‑91. (In Russ.)
https://doi.org/10.17116/jnevro202012012186

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To identify a possible correlation between parameters of thrombodynamic coagulation and negative syndromes in patients with schizophrenia.

MATERIAL AND METHODS

The study included 148 female inpatients, aged 16 to 57 years, with the following mental disorders: schizophrenia with attack-like/attack-progressive/continuous type of course (F20.00-2), schizotypal disorder with affective fluctuations (F21.3-4). The thrombodynamics test (TD) was carried out on a T-2 thrombodynamics recorder (Hemacore LLC, Moscow, Russia).

RESULTS

A positive correlation was shown between the thrombodynamic parameters of clot growth rates (V, Vst, and Vi), clot size at the 30th minute (CS), and the total severity of negative syndromes (PANSS). There is a negative correlation between the time of spontaneous clots (Tsp) and the total severity of negative syndromes in patients. Positive correlations of V and Vst with scores on the fourth (Passive/apathetic social withdrawal), fifth (Difficulty in abstract thinking) and seventh (Stereotyped thinking) items of the PANSS negative subscale were revealed. There is a negative correlation between Tsp and the score on the 7th item, i.e. a shorter time for the appearance of spontaneous clots corresponds to a more pronounced Stereotyped thinking in patients.

CONCLUSION

For the first time, correlations between thrombodynamic indicators of hypercoagulation and negative syndromes in patients with schizophrenia are identified, which emphasizes the need to normalize hemostasis to prevent further aggravation of these disorders.

Keywords:

schizophrenia
negative syndromes
PANSS
thrombodynamics
hypercoagulation
antidepressants
correlation

Authors:

Brusov O.S.

Mental Health Research Center

Oleĭchik I.V.

Mental Health Research Centre

Karpova N.S.

Mental Health Research Center

Faktor M.I.

Mental Health Research Center

Sizov S.V.

Mental Health Research Center

Received:

20.08.2020

Accepted:

28.08.2020

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