Features of the neuroradiological picture of ganglioglioma on the example of 20 clinical cases

Khalilov V.S.; Kholin A.A.; Gazdieva Kh.Sh.; Kislyakov A.N.; Zavadenko N.N.

doi:https://doi.org/10.17116/jnevro202012011190

Khalilov V.S.

Central Children Clinical Hospital of Federal Medical-Biological Agency;
Pirogov Russian National Research Medical University

Kholin A.A.

Pirogov Russian National Research Medical University

Gazdieva Kh.Sh.

Pirogov Russian National Research Medical University

Kislyakov A.N.

Morozov City Children’s Clinical Hospital of the Moscow Healthcare Department

Zavadenko N.N.

Pirogov Russian National Research Medical University

ORCID: 0000-0003-0103-7422

Features of the neuroradiological picture of ganglioglioma on the example of 20 clinical cases

Authors:

Khalilov V.S., Kholin A.A., Gazdieva Kh.Sh., Kislyakov A.N., Zavadenko N.N.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(11): 90‑98

DOI: 10.17116/jnevro202012011190

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To cite this article:

Khalilov VS, Kholin AA, Gazdieva KhSh, Kislyakov AN, Zavadenko NN. Features of the neuroradiological picture of ganglioglioma on the example of 20 clinical cases. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(11):90‑98. (In Russ.)
https://doi.org/10.17116/jnevro202012011190

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To analyze the images obtained during pre-surgical neuroimaging in patients with gangliomas for the presence of specific signs and verification of the neoplastic process.

MATERIAL AND METHODS

The results of presurgical MRI (3.0, 1.5 Tesla) of 20 patients with gangliomas were analyzed to identify specific signs of a neuronal-glial tumor and verify the neoplastic process based on the results obtained and a review of the literature. In addition to high-resolution MRI (HR MRI), various protocol modifications were applied to patients with epileptogenic pathological substrates of unclear etiology, including tractography (DTI) and contrast-free MR perfusion (ASL). In 5 cases, a multi-modal study was performed that combined the results of CT, routine MRI, HR MRI, functional MRI (fMRI) in various combinations and PET CT.

RESULTS AND CONCLUSION

In 17 cases, patients underwent epileptic surgery. Three patients without epilepsy were operated on for a tumor diagnosed by radiological examination. In all 20 cases, gangliogliomas were verified, including 1 anaplastic, 1 infantile desmoplastic, and another patient had histological samples showing signs of a composite tumor. Combination with FCD IIIb was observed in 3 cases. Two patients had a double pathology (cases of tumors combination with lissencephaly and neuronal heterotopia) and another had a composite neuronal-glial tumor. In 15 cases, gangliogliomas showed neuroradiological features typical for dysembryoplastic neuroepithelial tumor (DNT) such as multicystic, nodular, and diffuse (dysplastic) described in the literature. In addition, in 9 cases, they had significant signs of neoplastic process such as contrast enhancement, continued growth and remodeling of the underlying bone. Verification of the neoplastic process based on the results of neuroradiological studies was difficult in 6 cases. In 2 cases, it was not possible to confirm the presence of neoplasm by radiological methods, and in 1 patient, the verification of the tumor during differential diagnosis took more than 8 years. The most common differential diagnosis was performed with DNT and FCD type IIb, which have a number of similar neuroradiological features.

Keywords:

ganglioglioma

neuronal-glial tumors

epilepsy

neuroradiology

Authors:

Khalilov V.S.

Central Children Clinical Hospital of Federal Medical-Biological Agency;
Pirogov Russian National Research Medical University

Kholin A.A.

Pirogov Russian National Research Medical University

Gazdieva Kh.Sh.

Pirogov Russian National Research Medical University

Kislyakov A.N.

Morozov City Children’s Clinical Hospital of the Moscow Healthcare Department

Zavadenko N.N.

Pirogov Russian National Research Medical University

ORCID: 0000-0003-0103-7422

Received:

20.11.2020

Accepted:

24.11.2020

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References:

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