The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Rider F.K.

Moscow Research and Clinical Centre for Neuropsychiatry

Lebedeva A.V.

Pirogov Russian National Research Medical University;
Scientific Research Institute of Healthcare Organization and Medical Managemen

Mkrtchyan V.R.

Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department

Guekht A.B.

Moscow Research and Clinical Centre for Neuropsychiatry;
Pirogov Russian National Research Medical University

Epilepsy and COVID-19: patient management and optimization of antiepileptic therapy during pandemic

Authors:

Rider F.K., Lebedeva A.V., Mkrtchyan V.R., Guekht A.B.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(10): 100‑107

DOI: 10.17116/jnevro2020120101100

Read: 13702 times

Download PDF (RU)
Contact the author
Table of contents

EPILEPSY AND COVID-19: PATIENT MANAGEMENT AND OPTIMIZATION OF ANTIEPILEPTIC THERAPY DURING PANDEMIC
EPILEPSY AND COVID-19: PATIENT MANAGEMENT AND OPTIMIZATION OF ANTIEPILEPTIC THERAPY DURING PANDEMIC

To cite this article:

Rider FK, Lebedeva AV, Mkrtchyan VR, Guekht AB. Epilepsy and COVID-19: patient management and optimization of antiepileptic therapy during pandemic. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(10):100‑107. (In Russ.)
https://doi.org/10.17116/jnevro2020120101100

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Auto­nomic cardiovascular diso­rders in patients with epileptic and psychogenic non-epileptic seizures: a pilot study. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(2):13-20
Coro­navirus infe­ction as a risk factor in occlusive-stenotic lesions of the brachiocephalic arte­ries. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3-2):44-52
Diffuse changes in the brain in the acute phase of COVID-19 and after infe­ction. Russian Journal of Archive of Pathology. 2025;(1):5-15
Liver pathology in COVID-19. Russian Journal of Archive of Pathology. 2025;(1):53-59
A clinical case of the aortic rupture after SARS-CoV-2 in the patient with Stickler syndrom. Russian Journal of Preventive Medi­cine. 2025;(3):103-106
Post-COVID syndrome: orga­nizing COVID-19-associated pneumonia. Clinical case. Journal of Respiratory Medi­cine. 2025;(1):65-72
A personalized approach to the diagnosis of epilepsy in obese children. Labo­ratory Service. 2025;(1):5-12
mRNA cancer vaccines: features of problems and collisions. Mole­cular Gene­tics, Microbiology and Viro­logy. 2025;(1):3-16
SpO2/RR index in choosing the method for correction of acute respiratory failure in COVID-19 patients. Russian Journal of Anesthesiology and Reanimatology. 2025;(2):50-58
Post-Covid aortitis with cardiac invo­lvement: progressive aortic aneurysm combined with active myocarditis. Russian Journal of Archive of Pathology. 2025;(2):53-58
Abstract:

There is currently no data on the increased incidence of new coronavirus infection (COVID-19) or on the more severe course of the disease in patients with epilepsy. However, given the high prevalence of epilepsy among patients after age 60, an increased burden of somatic comorbidities among people with epilepsy, as well as the need of continuous access to antiepileptic drugs (AED) and care for patients with epilepsy, there are a number of important concerns in time of regarding the management of epilepsy during COVID-19 pandemic. The article discusses the main principles of epilepsy management during the COVID-19 pandemic: the need to comply with the regime; the importance of AED adherence, taking into account drug-drug interactions; switching patients to intravenous AED forms if necessary.

Keywords:

COVID-19
SARS-CoV-2
epilepsy
adherence to treatment
antiepileptic drugs
drug-drug interactions

Authors:

Rider F.K.

Moscow Research and Clinical Centre for Neuropsychiatry

Lebedeva A.V.

Pirogov Russian National Research Medical University;
Scientific Research Institute of Healthcare Organization and Medical Managemen

Mkrtchyan V.R.

Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department

Guekht A.B.

Moscow Research and Clinical Centre for Neuropsychiatry;
Pirogov Russian National Research Medical University

Received:

22.04.2020

Accepted:

16.09.2020

Close metadata

References:

  1. Fu L, Wang B, Yuan T, Chen X, Ao Y, Fitzpatrick T, Li P, Zhou Y, Lin Y, Duan Q, Luo G, Fan S, Lu Y, Feng A, Zhan Y, Liang B, Cai W, Zhang L, Du X, Shu Y, Li L, Zou H. Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis. Journal of Infection. 2020 (article in press). https://doi.org/10.1016/j.jinf.2020.03.041
  2. Niu S, Tian S, Lou J, Kang X, Zhang L, Lian H, Zhang J. Clinical Characteristics of Older Patients Infected with COVID-19: A Descriptive Study, Archives of Gerontology and Geriatrics. 2020. https://doi.org/10.1016/j.archger.2020.104058
  3. Vremennye metodicheskie rekomendacii. Profilaktika, diagnostika i lechenie novoj koronavirusnoj infekcii COVID-19. Versija 4 (27.03.20) MZ RF. (In Russ.).
  4. Vremennye metodicheskie rekomendacii. Profilaktika, diagnostika i lechenie novoj koronavirusnoj infekcii COVID-19. Versija 5 (08.04.20) MZ RF. (In Russ.).
  5. Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host—Virus Interaction, and Proposed Neurotropic Mechanisms. ACS Chem. Neurosci. 2020;34:54-59.  https://doi.org/10.1021/acschemneuro.0c00122
  6. Netland J, Meyerholz DK, Moore S, Cassell M, Perlman S. Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2. J Virol. 2008;82(15):7264-7275. https://doi.org/10.1128/JVI.00737-08
  7. Troyer EA, Kohn JN, Hong S. Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms. Brain, Behavior, and Immunity. 2020. https://doi.org/10.1016/j.bbi.2020.04.027
  8. Mao L, Wang M, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Li Y, Jin H, Hu B. Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study. MedRxiv. 2020;21:34-39.  https://doi.org/10.1101/2020.02.22.20026500
  9. Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may be at least partially responsible for the respiratory failure of COVID-19 patients. Journal of Medical Virology. 2020;13:56-61.  https://doi.org/10.1002/jmv.25728
  10. Asadi-Pooya AA, Simani L. Central nervous system manifestations of COVID-19: A systematic review. Journal of the Neurological Sciences. 2019. https://doi.org/10.1016/j.jns.2020.116832
  11. Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J, Ueno M, Sakata H, Kondo K, Myose N, Nakao A, Takeda M, Haro H, Inoue O, Suzuki-Inoue K, Kubokawa K, Ogihara S, Sasaki T, Kinouchi H, Kojin H, Ito M, Onishi H, Shimizu T, Sasaki Y, Enomoto N, Ishihara H, Furuya S, Yamamoto T, Shimada S. A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. International Journal of Infectious Diseases. 2020;12: 42-47.  https://doi.org/10.1016/j.ijid.2020.03.062
  12. Zhao H, Shen D, Zhou H, Liu J, Chen S. Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? Published online April 1, 2020. https://doi.org/10.1016/S1474-4422(20)30109-5
  13. Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L, Liu C, Yang C. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain, Behavior, and Immunity. 2020. https://doi.org/10.1016/j.bbi.2020.03.031
  14. https://www.ilae.org
  15. https://www.theabn.org/news/495261/ABN-Guidance-on-COVID-19-for-people-with-neurological-conditions.htm
  16. Maa E, Figi P. The case for medical marijuana in epilepsy. Epilepsia. 2014;55(6):783-786.  https://doi.org/10.1111/epi.12610
  17. https://www.cnn.com/2020/04/08/health/charlotte-figi-cbd-marijuana-dies/index.html
  18. https://www.dravet.org.uk/news/coronavirus-advice
  19. Téllez-Zenteno JF, Matijevic S, Wiebe S. Somatic comorbidity of epilepsy in the general population in Canada. Epilepsia. 2005;46(12):1955-1962. https://doi.org/10.1111/j.1528-1167.2005.00344.x
  20. Guekht A. Epilepsy, Comorbidities and Treatments. Curr Pharm Des. 2017;23(37):5702-5726. https://doi.org/10.2174/1381612823666171009144400
  21. Guekht AB, Lebedeva AV, Rider FK, Kaimovsky IL, Gudkova AA, Pavlov NA. Stroke and epilepsy: comorbidity, mechanisms of development, patterns of management. Materials of the International Congress dedicated to World stroke day. Edited by Gusev E.I., Guekht A.B., Martynov M.Yu. M.: Buki-Vedi; 2017. (In Russ.).
  22. Rider F, Solomatin Y, Akzhigitov R, Hauser A, Guekht A. Somatic and psychiatric comorbidity of epilepsy in adult population of Moscow. 5th EAN Congress in Oslo, Norway, 29.06—02.07.19. European Journal of Neurology. 2019;26(suppl 1):EPO3229:877.  https://doi.org/10.1111/ene.14019
  23. Tellez-Zenteno JF, Patten SB, Jetté N, Williams J, Wiebe S. Psychiatric comorbidity in epilepsy: a population-based analysis. Epilepsia. 2007;48(12):2336-2344. https://doi.org/10.1111/j.1528-1167.2007.01222.x
  24. Rider FK, Danilenko OA, Grishkina MN, Kustov GV, Akzhigitov RG, Lebedeva AV, Guekht AB. Depression and epilepsy: comorbidities, pathogenesis, principles of therapy. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2016;116(9):19-24. (In Russ.). https://doi.org/10.17116/jnevro20161169219-24
  25. Zinchuk MS, Rider FK, Kustov GV, Pashnin EV, Akzigitov RG, Gudkova AA, Guekht AB. Suicidality in epilepsy: epidemiology and clinical risk factors. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2018;118(10):45-52. (In Russ.). https://doi.org/10.17116/jnevro201811810245
  26. Rider FK, Gersamia AG. Adherence to treatment in patients with epilepsy: causes, assessment methods, improvement strategies. Multidisciplinary problems of treatment and prevention of brain diseases. Edited by Gusev E.I., Guekht A.B. M.: Buki-Vedi LLC; 2019. (In Russ.).
  27. https://www.who.int/chp/knowledge/publications/adherence_report/en/
  28. Malek N, Heath CA, Greene J. A review of medication adherence in people with epilepsy. Acta Neurol Scand. 2017;135(5):507-515.  https://doi.org/10.1111/ane.12703
  29. Lai SL, Hsu MT, Chen SS. The impact of SARS on epilepsy: the experience of drug withdrawal in epileptic patients. Seizure. 2005;14(8):557-561.  https://doi.org/10.1016/j.seizure.2005.08.010
  30. Rider FK, Lebedeva AV, Mkrtchyan VR, Guekht AB. Metodicheskie rekomendacii «Lechenie pacientov s jepilepsiej v uslovijah pandemii COVID-19». M. 2020. (In Russ.).
  31. https://www.covid19-druginteractions.org/
  32. https://www.crediblemeds.org/
  33. Aseckaja IL. Vzaimodejstvie antibiotikov s preparatami drugih lekarstvennyh grupp. Prakticheskaja pul’monologija. 2003;4:20-24. (In Russ.).
  34. Sutter R, Rüegg S, Tschudin-Sutter S. Seizures as adverse events of antibiotic drugs: A systematic review. Neurology. 2015;85(15):1332-1341. https://doi.org/10.1212/WNL.0000000000002023
  35. Carnovale C, Pozzi M, Mazhar F, Mosini G, Gentili M, Peeters GGAM, Clementi E, Radice S. Interactions Between Antiepileptic and Antibiotic Drugs: A Systematic Review and Meta-Analysis with Dosing Implications. Clin Pharmacokinet. 2019;58(7):875-886.  https://doi.org/10.1007/s40262-018-0720-z
  36. https://www.rlsnet.ru/mnn_index_id_3352.htm
  37. https://www.rlsnet.ru/mnn_index_id_3878.htm
  38. https://www.rlsnet.ru/mnn_index_id_272.htm
  39. https://www.rlsnet.ru/mnn_index_id_3005.htm
  40. https://www.rlsnet.ru/mnn_index_id_5524.htm
  41. Karlov VA, Lebedeva AV, Stepanenko AIu, Rudakova IG, Vlasov PN, Lipatova LV, Popugaev KA, Golovteev AL, Gekht AB. Possibilities of using intravenous forms of antiepileptic drugs in epileptic seizures. Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(4):66-75. PubMed PMID: 24874339. (In Russ.).
  42. https://www.ilae.org/files/dmfile/EpiCARE-webinars_2020.pdf
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.