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Alessenko A.V.

Institute of Biochemical Physic of the Russian Academy of Sciences

Gutner U.A.

Institute of Biochemical Physic of the Russian Academy of Sciences

Nebogatikov V.O.

Institute of Physiologically Active Compounds of the Russian Academy of Sciences

Shupik M.A.

Institute of Biochemical Physic of the Russian Academy of Sciences

Ustyugov A.A.

Institute of Physiologically Active Compounds of the Russian Academy of Sciences

The role of lipids in the pathogenesis of lateral amyotrophic sclerosis

Authors:

Alessenko A.V., Gutner U.A., Nebogatikov V.O., Shupik M.A., Ustyugov A.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(10): 108‑117

DOI: 10.17116/jnevro2020120101108

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To cite this article:

Alessenko AV, Gutner UA, Nebogatikov VO, Shupik MA, Ustyugov AA. The role of lipids in the pathogenesis of lateral amyotrophic sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(10):108‑117. (In Russ.)
https://doi.org/10.17116/jnevro2020120101108

 
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Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by selective degeneration of motor neurons of the motor cortex, brain stem and brain stem. Mutations in genes coding for SOD1, C9ORF72, TDP-43, FUS and others are associated with ALS and result in abnormal processing and transport of RNA as well as changes in the dynamics of cytoskeleton. In addition, a sharp change in the metabolism of various lipid classes, including phospholipids, fatty acids, sphingolipids, etc., was detected. This review describes changes in lipid content and activity of enzymes involved in their metabolism in ALS animal models as well as in patients. Changes in the metabolism of fatty acids, phospholipids, cholesterol and its derivatives are reviewed in detail. The prospects of searching for new drugs among modulators of lipid metabolism enzymes are discussed.

Keywords:

amyotrophic lateral sclerosis (ASA)
ALS models
lipids
fatty acids
phospholipids
cholesterol

Authors:

Alessenko A.V.

Institute of Biochemical Physic of the Russian Academy of Sciences

Gutner U.A.

Institute of Biochemical Physic of the Russian Academy of Sciences

Nebogatikov V.O.

Institute of Physiologically Active Compounds of the Russian Academy of Sciences

Shupik M.A.

Institute of Biochemical Physic of the Russian Academy of Sciences

Ustyugov A.A.

Institute of Physiologically Active Compounds of the Russian Academy of Sciences

Received:

08.11.2019

Accepted:

10.04.2020

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