The role of genetic factors in the development of suicidal behavior in individuals with dependence on synthetic cathinones

Gareeva A.E.; Badretdinov U.G.; Akhmetova E.A.; Kinyasheva K.O.; Nasibullin T.R.; Samigullina L.I.; Timerbulatov I.F.; Timerbulatova M.F.; Asadullin A.R.

doi:https://doi.org/10.17116/jnevro202012010169

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OBJECTIVE

To identify polymorphisms in the genes of dopaminergic and serotonergic systems associated with the risk of suicidal behavior in individuals with dependence on synthetic cathinones.

MATERIAL AND METHODS

One hundred and eighty-two men with the diagnosis of Substance dependence (ICD-10 F15) tested positive for metabolites of synthetic cathinones (a-PVP, MDPV) in the urine were studied. Genotyping was performed for rs1800497 DRD2, rs4646984 DRD4, VNTR 40 b.p. SLC6A3, rs27072 SLC6A3, rs6313 HTR2A and rs6296 HTR1B using PCR and RFLP technique.

RESULTS AND CONCLUSION

It was found that the genes of the serotonergic system HTR2A and HTR1B are predictors of the development of some endophenotypes of suicidal behavior in individuals with dependence on synthetic cathinones.

Keywords:

polymorphisms

genes

dependence on psychoactive substances

synthetic cathinones

suicidal behavior

Authors:

Gareeva A.E.

Bashkir State Medical University;
Institute of Biochemistry and Genetics, the Russian Academy of Sciences

Badretdinov U.G.

Bashkir State Medical University

Akhmetova E.A.

Bashkir State Medical University

Kinyasheva K.O.

Institute of Biochemistry and Genetics, the Russian Academy of Sciences

Nasibullin T.R.

Institute of Biochemistry and Genetics of Ufa Federal Research Centre

ORCID: 0000-0001-8823-8678

Samigullina L.I.

Bashkir State Medical University

Timerbulatov I.F.

Bashkir State Medical University

Timerbulatova M.F.

Bashkir State Medical University

Asadullin A.R.

Bashkir State Medical University

Received:

12.04.2019

Accepted:

20.04.2019

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References:

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