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Akhmadeeva L.R.

Bashkirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Ufa

Akhmedzhanova L.T.

Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova

Barinov A.N.

Sechenov First Moscow State Medical University, Moscow

Burdakov V.V.

Orenburg State Medical University, Orenburg, Russia

Guryanova E.A.

Ulyanov Churash State University, Cheboksary, Russia

Kopishinskaia S.V.

Kafedra nevrologii, psikhiatrii i narkologii fakul'teta povysheniia kvalifikatsii vracheĭ GBOU VPO "Nizhegorodskaia gosudarstvennaia meditsinskaia akademiia", Nizhniĭ Novgorod

Makhinov K.A.

Sechenov First Moscow State Medical University, Moscow

Parkhomenko E.V.

Altai State Medical University, Barnaul

Sergienko D.A.

Sechenov First Moscow Medical State University, Moscow, Russia

Strokov I.A.

Kafedra nervnykh bolezneĭ

Cherkasova V.G.

Permskaia gosudarstvennaia meditsinskaia akademiia im. akad. E.A. Vagnera, gorodskaia poliklinika #3, Perm'

Shcherbonosova T.A.

Postgraduate Institute for Healthcare Specialists, Khabarovsk, Russia

Iakupov É.Z.

Kafedra nevrologii, neĭrokhirurgii i meditsinskoĭ genetiki Kazanskogo gosudarstvennogo meditsinskogo universiteta

'Point of no return' in diabetic neuropathies: a dangerous delusion

Authors:

Akhmadeeva L.R., Akhmedzhanova L.T., Barinov A.N., Burdakov V.V., Guryanova E.A., Kopishinskaia S.V., Makhinov K.A., Parkhomenko E.V., Sergienko D.A., Strokov I.A., Cherkasova V.G., Shcherbonosova T.A., Iakupov É.Z.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(8): 98‑107

DOI: 10.17116/jnevro201911908198

Read: 7100 times

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Table of contents

'POINT OF NO RETURN' IN DIABETIC NEUROPATHIES: A DANGEROUS DELUSION
'POINT OF NO RETURN' IN DIABETIC NEUROPATHIES: A DANGEROUS DELUSION

To cite this article:

Akhmadeeva LR, Akhmedzhanova LT, Barinov AN, et al. . 'Point of no return' in diabetic neuropathies: a dangerous delusion. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(8):98‑107. (In Russ.)
https://doi.org/10.17116/jnevro201911908198

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Использование инфографики авторами научных работ
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Abstract:

Polyneuropathy in patients with diabetes mellitus is manifested by a lesion of peripheral sensory, motor and autonomic nervous system. Different severity of damage of sensory, motor and autonomic fibers in typical and atypical forms of diabetic polyneuropathy, requires a differentiated approach to therapy, but not the rejection of its implementation. In an interdisciplinary consensus, consultations are held with physicians from different regions of the Russian Federation, and modern methods of diagnosing and assessing the severity of diabetic polyneuropathies, which determine the algorithm for treating patients, are discussed.

Keywords:

diabetic polyneuropathy
neuropathic pain
gabapentinoids
antidepressants
thioctic acid
benfotiamine
neurotropic therapy
pentasinergy
neuroplasticity
point of no return
therapeutic nihilism
socioplasticity
interdisciplinary consensus on DPN

Authors:

Akhmadeeva L.R.

Bashkirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Ufa

Akhmedzhanova L.T.

Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova

Barinov A.N.

Sechenov First Moscow State Medical University, Moscow

Burdakov V.V.

Orenburg State Medical University, Orenburg, Russia

Guryanova E.A.

Ulyanov Churash State University, Cheboksary, Russia

Kopishinskaia S.V.

Kafedra nevrologii, psikhiatrii i narkologii fakul'teta povysheniia kvalifikatsii vracheĭ GBOU VPO "Nizhegorodskaia gosudarstvennaia meditsinskaia akademiia", Nizhniĭ Novgorod

Makhinov K.A.

Sechenov First Moscow State Medical University, Moscow

Parkhomenko E.V.

Altai State Medical University, Barnaul

Sergienko D.A.

Sechenov First Moscow Medical State University, Moscow, Russia

Strokov I.A.

Kafedra nervnykh bolezneĭ

Cherkasova V.G.

Permskaia gosudarstvennaia meditsinskaia akademiia im. akad. E.A. Vagnera, gorodskaia poliklinika #3, Perm'

Shcherbonosova T.A.

Postgraduate Institute for Healthcare Specialists, Khabarovsk, Russia

Iakupov É.Z.

Kafedra nevrologii, neĭrokhirurgii i meditsinskoĭ genetiki Kazanskogo gosudarstvennogo meditsinskogo universiteta

Close metadata

References:

  1. Maffi P, Secchi A. The Burden of Diabetes: Emerging Data. Dev Ophthalmol. 2017;60:1-5. https://doi.org/10.1159/000459641
  2. Ziegler D, Rathmann W, Dickhaus T, Meisinger C, Mielck A; KORA Study Group. Neuropathic pain in diabetes, prediabetes and normal glucose tolerance: the MONICA/KORA Augsburg Surveys S2 and S3. Pain Med. 2009;10(2):393-400. https://doi.org/10.1111/j.1526-4637.2008.00555.x
  3. Ziegler D, Paranas N, Vinic A, Shaw JE. Epidemiology of polyneuropathy in diabetes and prediabetes. Handb Clin Neurol. 2014;126:3-22. https://doi.org/10.1016/b978-0-444-53480-4.00001-1
  4. Spallone V, Ziegler D, Freeman R, Bernardi L, Frontoni S, Pop-Busui R, Stevens M, Kempler P, Hilsted J, Tesfaye S, Low P, Valensi P. Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management. Diabetes Metab Res Rev. 2011;27:7:639-653. https://doi.org/10.1002/dmrr.1239
  5. Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik R, Sosenko J, Zieglar D. Diabetic neuropathy: a position statement by the american diabetes association. Diabetes Care. 2017;40(1):136-154. https://doi.org/10.2337/dc16-2042
  6. Ziegler D, Hanefeld M, Ruhnau KJ, Meissner HP, Lobisch M, Schütte K, Gries FA. Treatment of symptomatic diabetic peripheral neuropathy with the antioxydant alpha-lypoic acid. (ALADIN study group). Diabetologica. 1995;38:1425-1433. https://doi.org/10.1007/bf00400603
  7. Bril V. NIS-LL: The primary measurement scale for clinical trial endpoints in diabetic peripheral neuropathy. Eur Neurol. 1999;41:8-13. https://doi.org/10.1159/000052074
  8. Valk GD, Nauta JJP, Strigers RLM, Bertelsmann SW. Clinical examination versus neurophysiological examination in the diagnosis of diabetic polyneuropathy. Diabetic Medicine. 1992;9:716-721. https://doi.org/10.1111/j.1464-5491.1992.tb01879.x
  9. Kopishinskaya SV, Gustov AV, Kolchanova TV. Immunohistochemistry of skin biopsy with counting C-fibers as a new modern method for diagnosing polyneuropathy. Archives of Pathology. 2015;3:43-49. (In Russ.)
  10. Barinov AN. Autonomic neuropathy in diabetes mellitus and metabolic syndrome. Effectivnaya Pharmacoterapiya. 2017;2:40-52. (In Russ.)
  11. Bregovsky VB, Khutornaya OE, Karpova IA. The role of alpha-lipoic acid in the complex treatment of diabetic polyneuropathy of the lower extremities. Consilium Medicum. Neurology and Rheumatology (App.). 2014;02:43-46. (In Russ.)
  12. Akhmedzhanova LT, Barinov AN, Strokov IA. Diabetic and non-diabetic polyneuropathy in patients with diabetes. Journal of Neurology and Psychiatry. 2018;4:118:113-121. (In Russ.)
  13. Ziegler D, Ametov A, Barinov A, Dyck PJ, Gurieva I, Low PA, Munzel U, Yakhno N, Raz I, Novosadova M, Maus J, Samigullin R. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy the SYDNEY 2 trial. Diabetes Care. 2006;29:2365-2370. https://doi.org/10.2337/dc06-1216
  14. Ziegler D, Nowak H, Kempler P, Vargha P, Low PA. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis. Diabet Med. 2004;21:114-121. https://doi.org/10.1111/j.1464-5491.2004.01109.x
  15. Almeida O, Ford A, Hirani V, Singh V, vanBockxmeer F, McCaul K, Flicker L. B vitamins to enhance treatment response to antidepressants in middle-aged and older adults: results from the B-VITAGE randomised, double-blind, placebo-controlled trial. The British Journal of Psychiatry. 2014;205(6):450-457. https://doi.org/10.1192/bjp.bp.114.145177
  16. Van der Wal S, van den Heuvel S, Radema S van Berkum BFM, Vaneker M, Steegers MAH, Scheffer GJ, Vissers KCP. The in vitro mechanisms and in vivo efficacy of intravenous lidocaine on the neuroinflammatory response in acute and chronic pain. Eur J Pain. 2016;20(5):655-674. https://doi.org/10.1002/ejp.794
  17. Werdehausen R, Kremer D, Brandenburger T, Schlösser L, Jadasz J, Küry P, Bauer I, Aragón C, Eulenburg V, Hermanns H. Lidocaine metabolites inhibit glycine transporter 1: A novel mechanism for the analgesic action of systemic lidocaine? Anesthesiology. 2012;116(1):147-158. https://doi.org/10.1097/aln.0b013e31823cf233
  18. Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel R. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomized, double-blind, placebo-controlled clinical trial. Exp Clin Endocrinol Diabetes. 2008;116:10: 600-605. https://doi.org/10.1055/s-2008-1065351
  19. Mimenza AA, Aguilar NS. Clinical Trial Assessing the Efficacy of Gabapentin Plus B Complex (B1/B12) versus Pregabalin for Treating Painful Diabetic Neuropathy. J Diabetes Res. 2016;4078695. https://doi.org/10.1155/2016/4078695
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