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Pereverzev A.P.

Russian Clinical and Research Center of Gerontology of Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia

Ostroumova O.D.

Kafedra fakul'tetskoĭ terapii i professional'nykh bolezneĭ Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta im. A.I. Evdokimova, Moskva

Isaev R.I.

Russian Clinical and Research Center of Gerontology of Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia

Tkacheva O.N.

Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia

Kotovskaya Yu.V.

FGBOU VO RNIMU OSP «Russian gerontological scientific and clinical center» named after N.I. Pirogov, Moscow, Russia

Drug-induced delirium in elderly and senile patients

Authors:

Pereverzev A.P., Ostroumova O.D., Isaev R.I., Tkacheva O.N., Kotovskaya Yu.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(7): 120‑127

DOI: 10.17116/jnevro2019119071120

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Table of contents

DRUG-INDUCED DELIRIUM IN ELDERLY AND SENILE PATIENTS
DRUG-INDUCED DELIRIUM IN ELDERLY AND SENILE PATIENTS

To cite this article:

Pereverzev AP, Ostroumova OD, Isaev RI, Tkacheva ON, Kotovskaya YuV. Drug-induced delirium in elderly and senile patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(7):120‑127. (In Russ.)
https://doi.org/10.17116/jnevro2019119071120

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

Drug-induced delirium is an urgent challenge of modern healthcare, especially in elderly patients, due to the widespread prevalence, associated complications, longer hospitalization period, higher mortality rate. The exact pathogenesis of delirium is unknown, however, a number of studies suggest that it is based on neurotransmitter dysfunction. Thus, drugs that affect the metabolism of these neurotransmitters can lead to the onset of delirium. The Delirium Drug Scale (DDS) and the Anticholinergic Burden scale (ACB) are used to assess the risk of delirium. For patients with an increased risk of delirium, it is recommended to avoid prescribing benzodiazepines, use with caution opiates, dihydropyridines and antagonists of H1-histamine receptors. Non-pharmacological methods are recommended as a first-line treatment of delirium (behavioral approaches, placing the patient in specially equipped delirious rooms, etc.). If non-pharmacological methods have shown to be ineffective or the patient’s behavior represents a danger to the life and health of himself and / or others, it is possible to administer antipsychotic drugs.

Keywords:

pharmacotherapy
elderly
delirium
drug-induced delirium
risk factors
adverse drug reactions

Authors:

Pereverzev A.P.

Russian Clinical and Research Center of Gerontology of Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia

Ostroumova O.D.

Kafedra fakul'tetskoĭ terapii i professional'nykh bolezneĭ Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta im. A.I. Evdokimova, Moskva

Isaev R.I.

Russian Clinical and Research Center of Gerontology of Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia

Tkacheva O.N.

Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia

Kotovskaya Yu.V.

FGBOU VO RNIMU OSP «Russian gerontological scientific and clinical center» named after N.I. Pirogov, Moscow, Russia

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