The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Vasilyeva E.F.

Mental Health Research Center

Brusov O.S.

Mental Health Research Center

Platelets, hemostasis and mental disorders

Authors:

Vasilyeva E.F., Brusov O.S.

More about the authors

Read: 10831 times


To cite this article:

Vasilyeva EF, Brusov OS. Platelets, hemostasis and mental disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(11):103‑108. (In Russ.)
https://doi.org/10.17116/jnevro2019119111103

Recommended articles:
FA2H gene-associated spastic para­plegia (SPG35) — fami­lial case with late onset. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):137-144
Modern concepts of sleep disturbances asso­ciated with mental diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):7-12
Pediatric autoimmune ence­phalitis: A clinical asse­ssment by a psychiatrist. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(10):144-149
Cogi­tum in the treatment of mental diso­rders in childhood. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(10-2):88-95
Intraopertive use of local hemo­statics in infe­cted wounds. Piro­gov Russian Journal of Surgery. 2025;(11):94-100
Thro­mbotic Hazard Markers: Thro­mbomodulin. Journal of Venous Diso­rders. 2025;(4):296-306

References:

  1. Hoirisch-Clapauch S, Nardi AE, Gris JC, Brenner B. Coagulation and mental disorders. Rambam Maimonides Med J. 2014;5.  https://doi.org/10.5041/RMMJ.10170
  2. Brass LF, Tomaiuolo MJ, Welsh I, Poventud-Fuentes LS, Diamond L, Stalker TJ. Hemostatic thrombus formation in flowing blood. Platelets (Fourth Edition). 2019;371-391.  https://doi.org/10.1016/B978-0-12-813456-6.00020-5
  3. Lima HY, O’Malleyd C, Donnanc G, Nandurkarb H, Hoa P. A review of global coagulation assays — Is there a role in thrombosis risk prediction. Science Direct Thrombosis. 2019; 04.033. Received 22 March 2019. https://doi.org/10.1016/j.thromres.2019.04.033
  4. Blockmans D, Deckmyn H, Vermylen J. Platelet activation. Blood Rev. 1995;9(3):143-156. 
  5. Gawaz M, Borst O. The role of platelets in atherothrombosis. Platelets (Fourth Edition). 2019;459-467. Get rights and content https://doi.org/10.1016/B978-0-12-813456-6.00026-6
  6. Weyrich P, Georges G, Artunc F, Guthoff M, Fend F, Horger M, Wolf S. Retroperitoneal masses: two case reports — Case 11/2009. Dtsch Med Wochenschr. 2009;134(48):2458. Epub 2009 Nov 18.  https://doi.org/10.1055/s-0028-1082835
  7. Horstman LL, Jy W, Ahn YS, Zivadinov R, Maghzi AH, Etemadifar M, Steven AJ, Minagar A. Role of platelets in neuroinflammation: a wide-angle perspective. J Neuroinflammation. 2010;3:7-10. Review. https://doi.org/10.1186/1742-2094-7-10
  8. Leslie M. Cell biology. Beyond clotting: the powers of platelets. Science. 2010;328:562-564.  https://doi.org/10.1126/science.328.5978.562
  9. Smith TL, Weyrich AS. Platelets as central mediators of systemic inflammatory responses. Thromb Res. 2011;127:391-394. Epub 2010 Nov 11. Review. https://doi.org/10.1016/j.thromres.2010.10.013
  10. Broos K, Feys HB, De Meyer SF, Vanhoorelbeke K, Deckmyn H. Platelets at work in primary hemostasis. Blood Rev. 2011;25:155-167. Epub 2011 Apr 14.  https://doi.org/10.1016/j.blre.2011.03.002
  11. Brogren H, Karlsson L, Andersson M, Wang L, Erlinge D, Jern S. Platelets synthesize large amounts of active plasminogen activator inhibitor 1. Blood. 2004;104:3943-3948. https://doi.org/10.1182/blood-2004-04-1439
  12. Li S, Wei X, He J, Tian X, Yuan S, Sun L. Plasminogen activator inhibitor-1 in cancer research. Biomed Pharmacother. 2018;105:83-94.  https://doi.org/10.1016/j.biopha.2018.05.119
  13. Al Ghumlas AK, Abdel Gader AGM. The blood platelet: an intriguing cell. J Applied Hematol. 2013;4:1-12. 
  14. George JN. Platelets. Lancet. 2000;355(9214):1531-1539. https://doi.org/10.1016/S0140-6736(00)02175-9
  15. Panteleyev MA, Vasil’yev SA, Sinauridze YeI, Vorob’yev AI, Ataullakhanov FI. Prakticheskaya koagulologiya. Pod red. Vorob’yeva A.I. M.: Izdatel’stvo Prakticheskaya meditsina; 2011. (In Russ.).
  16. Weyrich AS, Schwertz H, Kraiss LW, Gay A. Protein synthesis by platelets: historical and new perspectives. J Thromb Haemost. 2009;7:241-246.  https://doi.org/10.1111/j.1538-7836.2008.03211.x
  17. Wachowicz B. Blood platelet as a peripheral cell in oxidative stress in psychiatric disorders In: Dietrich-Muszalska A., Chauhan V., Grignon S., editors. Studies on psychiatric disorders, oxidative stress in applied basic research and clinical practice. New York: Springer; 2015. https://doi.org/10.1007/978-1-4939-0440-2
  18. Kuznik BI. Sistema gemostaza. Fiziologiya cheloveka. Pod red. Pokrovskiy V.M., Korot’ko G.F. M:. Izdatel’stvo Meditsina; 2000. (In Russ.).
  19. Lindemann S, Gawaz M. The active platelet: translation and protein synthesis in an anucleate cell. Semin Thromb Hemost. 2007;33(2):144-150.  https://doi.org/10.1055/s-2007-969027
  20. Zimmerman GA, Weyrich AS. Signal-dependent protein synthesis by activated platelets new pathways to altered phenotype and function. Arterioscler Thromb Vasc Biol. 2008;28(3):17-24.  https://doi.org/10.1161/ATVBAHA.107.160218
  21. Kamath S, Blann AD, Lip GY. Platelet activation: assessment and quantification. Eur Heart J. 2001;22:1561-1571. https://doi.org/10.1053/euhj.2000.2515
  22. Li Z, Delaney MK, O'Brien KA, Du X. Signaling during platelet adhesion and activation. Arterioscler Thromb Vasc Biol. 2010;30:2341-2349. https://doi.org/10.1161/ATVBAHA.110.207522
  23. Dietrich-Muszalska A, Wachowicz B. Platelet haemostatic function in psychiatric disorders: effects of antidepressant and antipsychotic drugs. World J Biol Psychiatry. 2017;18(8):564-574.  https://doi.org/10.3109/15622975.2016.1155748
  24. Camacho A, Dimsdale JE. Platelets and psychiatry: lessons learned from old and new studies. Psychosom Med. 2000;62(3):326-336. 
  25. Bakken M, Staeffler A, Jorgensen HA, Holmsen H. Glycerophospholipid molecular species in platelets and brain tissues — are platelets a good model for neurons? Platelets. 2006;17:484-492.  https://doi.org/10.1080/09537100600759196
  26. Papakostas GI, Stahl SM, Krishen A, Seifert CA, Tucker VL, Goodale EP, Fava M. Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of major depressive disorder with high levels of anxiety (anxious depression): a pooled analysis of 10 studies. J Clin Psychiatry. 2008;69(8):1287-1292.
  27. Berk M, Plein H, Belsham B. The specificity of platelet glutamate receptor supersensitivity in psychotic disorders. Life Sci. 2000;66:2427-2432.
  28. Berk M, Plein H, Ferreira D, Jersky B. Blunted adenosine A2a receptor function in platelets in patients with major depression. Eur Neuropsychopharmacol. 2001;11(2):183-186. 
  29. Plein H, Berk M. The platelet as a peripheral marker in psychiatric illness. Hum Psychopharmacol. 2001;16:229-236.  https://doi.org/10.1002/hup.251
  30. Pellerin D, Lortie A, Corbin F. Platelets as a surrogate disease model of neurodevelopmental disorders: Insights from Fragile X Syndrome. Platelets. 2018;29(2):113-124.  https://doi.org/10.1080/09537104.2017.1317733
  31. Brusov OS, Faktor MI, Zlobina GP, Dupin AM, Katasonov AB, Dmitriev AD, Pavlova EV, Beniashvili AG, Morozova MA. Platelet serotonergic parameters and clinical symptoms of psychosis in patients with episodic progressive schizophrenia. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2007;107(4):17-24. (In Russ.)].
  32. Klushnik TP, Syriachenko TM, Brusov OS, Sarmanova ZV, Otman IN, Dupin AM, Sokolov RE. Serum immunological markers as predictors of effectiveness of antipsychotic therapy in patients with schizophrenia. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2008;108(1):31-35. (In Russ.).
  33. Shimizu M, Kanazawa K, Matsuda Y, Takai E, Iwai C, Miyamoto Y, Hashimoto M, Akita H, Yokoyama M. Serotonin-2A receptor gene polymorphisms are associated with serotonin-induced platelet aggregation. Thromb Res. 2003;112(3):137-142. 
  34. Ehrlich D, Humpel C. Platelets in psychiatric disorders. World J Psychiatry. 2012;2:91-94.  https://doi.org/10.5498/wjp.v2.i6.91
  35. Koudouovoh-Tripp P, Spemer-Unterweger B. Influence of mental stress on platelet bioactivity. World J Psychiatry. 2012;2:134-147. 
  36. Wu JQ, Kosten TR, Zhang XY. Free radicals, antioxidant defense systems, and schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2013;46:200-206. 
  37. Zhang XY, Yao JK. Oxidative stress and therapeutic implications in psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2013;46:197-199.  https://doi.org/10.1016/j.pnpbp.2013.03.003
  38. Lesch KP, Wolozin BL, Murrphy DL, Reiderer P. Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. J Neurochem. 1993;60:2319-2322.
  39. Williams MS. Platelets and depression in cardiovascular disease: a brief review jf the current literature. World J Pshychiatry. 2012;2:114-123. 
  40. Lopez-Vilchez I, Serra-Millas M, Navarro V, Rosa Hernandez M, Villalta J, Diaz-Ricart M, Gasto C, Escolar G, Galan AM. Prothrombotic platelet phenotype in major depression: downregulation by antidepressant treatment. J Affect Disord. 2014;159:39-45.  https://doi.org/10.1016/j.jad.2014.02.022
  41. Lebedeva EV, Gutkevich EV, Ivanova SA, Schastnyy ED, Simutkin GG, Semke VYa, Sergienko TN, Shmigol’ MV, Ryadovaya LA, Repin AN. Phenomenon of co-morbid depression and coronary artery disease within current achievements of genetics. Sibirskiy Vestnik Psikhiatrii i Narkologii. 2012;6(75):41-47. (In Russ).
  42. Golimbet VE, Korovaitseva GI, Brusov OS, Faktor MI, Ganisheva TK, Dmitriev DA. The functional state of the serotonergic system and the 5-HTTLPR polymorphism of the serotonin transporter gene in patients with schizophrenia. Mol Biol (Mosk). 2010;44(2):251-256. (In Russ.).
  43. Stahl SM. The human platelet. A diagnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorders. Arch Gen Psychiatry. 1977;34:509-516. 
  44. Bokhan NA, Ivanova SA, Levchuk LA. Serotonin system in modulation of depressive and addictive behavior. The National Research Tomsk State University. 2013. (In Russ.).
  45. Peitl V, Vidrih B, Karlović Z, Getaldić B, Peitl M, Karlović D. Platelet serotonin concentration and depressive symptoms in patients with schizophrenia. Psychiatry Res. 2016;239:105-110. Epub 2016 Mar 4.  https://doi.org/10.1016/j.psychres.2016.03.006
  46. De Clerck FF, Janssen PA. Amplification mechanisms in platelet activation and arterial thrombosis. J Hypertens Suppl. 1990;8(7):87-93. 
  47. Konopka LM, Cooper R, Crayton JW. Serotonin-induced increases in platelet cytosolic calcium concentration in depressed, schizophrenic, and substance abuse patients. Biol Psychiatry. 1996;39:708-713. 
  48. Nemeroff CB, Musselman DL. Are platelets the link between depression and ischemic heart disease. Am Heart J. 2000;140:57-62. 
  49. Nemeroff CB, Owens MJ. The role of serotonin in the pathophysiology of depression: as important as ever. Clin Chem. 2009;55:1578-1579. https://doi.org/10.1373/clinchem.2009.123752
  50. Nagatomo T, Rashid M, Abul Muntasir H, Komiyama T. Functions of 5-HT2A receptor and its antagonists in the cardiovascular system. Pharmacol Ther. 2004;104:59-81.  https://doi.org/10.1016/j.pharmthera.2004.08.005
  51. Przyklenk K, Frelinger A, Linden MD, Whittaker P, Li Y, Barnard MR, Adams J, Morgan M, Al-Shamma H, Michelson AD. Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recrutment thrombosis. J Thromb Haemostas. 2010;8:331-340.  https://doi.org/10.1111/j.1538-7836.2009.03693.x
  52. Doulalas AD, Rallidis LS, Gialernios T, Moschonas DN. Association of depressive symptoms with coagulation factors in young healthy individuals. Atherosclerosis. 2006;186(1):121-125.  https://doi.org/10.1016/j.atherosclerosis.2005.06.030
  53. Elmi S, Sahu G, Malavade K, Jacob T. Role of tissue plasminogen activator and plasminogen activator inhibitor as potential biomarkers in psychosis. Asian J Psychiatr. 2019;43:105-110.  https://doi.org/10.1016/j.ajp.2019.05.021
  54. Allebeck P. Schizophrenia: A life-shortening illness. Schizophr. 1989;15:81-89. 
  55. Joukamaa M, Heliovaara M, Knekt P, Aromaa A, Raitasalo R, Lehtinen V. Schizophrenia, neuroleptic medication and mortality. Br J Psychiatry. 2006;188:122-127.  https://doi.org/10.1192/bjp.188.2.122
  56. Yetkin E. Mean platelet volume not so far from being a routine diagnostic and prognostic measurement. Thromb Haemost. 2008;100:3-4.  https://doi.org/10.1160/TH08-05-0336

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.