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Kutlubaev M.A.

Nevrologicheskoe otdelenie Respublikanskoĭ klinicheskoĭ bol'nitsy im. G.G. Kuvatova

Mendelevich V.D.

Kazanskiĭ gosudarstvennyĭ meditsinskiĭ universitet

The problem of aggressive behavior in epilepsy: clinical and neurobiological aspects

Authors:

Kutlubaev M.A., Mendelevich V.D.

More about the authors

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To cite this article:

Kutlubaev MA, Mendelevich VD. The problem of aggressive behavior in epilepsy: clinical and neurobiological aspects. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(7):94‑100. (In Russ.)
https://doi.org/10.17116/jnevro20181187194

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References:

  1. Kazakovtcev BA. Psychiatric disorders in epilepsy. M. 1999. (In Russ.)
  2. Kalinin VV. Epilepsy as a neuropsychiatric problem. Zhurnal im. P.B. Gannushkina Psikhiatriya i psikhopharmakologiya. Supp. №1 «Epilepsy: diagnosis and treatment». 2004;5-6. (In Russ.)
  3. Usyukina MV, Kornilova SV, Shamanaev AS. Dysphoric disorders in epilepsy. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2016;116(3):15-19. (In Russ.)
  4. Kornilova SV. Aggressive behavior and public danger of people, suffering from epilepsy (forensic and psychiatric aspect): Dis... kand. med. nauk. M. 2007. (In Russ.)
  5. Bogdanovic MD, Mead SH, Duncan JS. Aggressive behavior at a residential epilepsy centre. Seizure. 2000;9:58-64. https://doi.org/10.1053/seiz.1999.0363
  6. Elnazer HY, Agrawal N. Aggressive Behavior In: M. Mula Ed., Neuropsychiatric Symptoms of Epilepsy. Springer International Publishing AG Switzerland. 2016;99-116. https://doi.org/10.1007/978-3-319-22159-5
  7. Piazzini A, Bravi F, Edefonti V, Turner K, Vignoli A, Ferraroni M, Canevini MP. Aggressive behavior and epilepsy: a multicenter study. Epilepsia. 2012;53:174-179. https://doi.org/10.1111/j.1528-1167.2012.03643.x
  8. Rosell DR, Siever LJ. The neurobiology of aggression and violence. CNS Spectr. 2015;20:254-279. https://doi.org/10.1017/s109285291500019x
  9. Kalinin VV, Polianskiĭ DA. Suicide risk factors in epileptic patients. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2003;103(3):18-21. (In Russ.)
  10. Kutlubaev MA. Suicidal behavior in neurological diseases: frequency, predictors and prevention measures. Nevrologicheskiy Zhurnal. 2016;21(3):124-130. (In Russ.) https://doi.org/10.18821/1560-9545-2016-21-3-124-130
  11. Matthies S, Rüsch N, Weber M, Lieb K, Philipsen A, Tuescher O, Ebert D, Hennig J, van Elst LT. Small amygdala-high aggression? The role of the amygdala in modulating aggression in healthy subjects. World J Biol Psychiatry. 2012;13:75-81. https://doi.org/10.3109/15622975.2010.541282
  12. Pardini DA, Raine A, Erickson K, Loeber R. Lower amygdala volume in men is associated with childhood aggression, early psychopathic traits, and future violence. Biol Psychiatry. 2014;75:73-80. https://doi.org/10.1016/j.biopsych.2013.04.003
  13. Sah P, Faber ES, Lopez De AM, Power J. The amygdaloid complex: anatomy and physiology. Physiol Rev. 2003;83:803-834. https://doi.org/10.1152/physrev.00002.2003
  14. Gopal A, Clark E, Allgair A, D’Amato C, Furman M, Gansler DA, Fulwiler C. Dorsal/ventral parcellation of the amygdala: relevance to impulsivity and aggression. Psychiatry Res. 2013;211:24-30. https://doi.org/10.1016/j.pscychresns.2012.10.010
  15. Bobes MA, Ostrosky F, Diaz K, Romero C, Borja K, Santos Y, Valdés-Sosa M. Linkage of functional and structural anomalies in the left amygdala of reactive aggressive men. Soc Cogn Affect Neurosci. 2013;8:928-936. https://doi.org/10.1093/scan/nss101
  16. New AS, Hazlett EA, Newmark RE, Zhang J, Triebwasser J, Meyerson D, Lazarus S, Trisdorfer R, Goldstein KE, Goodman M, Koenigsberg HW, Flory JD, Siever LJ, Buchsbaum MS. Laboratory induced aggression: a positron emission tomography study of aggressive individuals with borderline personality disorder. Biol Psychiatry. 2009;66:1107-1114. https://doi.org/10.1016/j.biopsych.2009.07.015
  17. Lozier LM, Cardinale EM, Vanmeter JW, Marsh AA. Mediation of the relationship between callous-unemotional traits and proactive aggression by amygdala response to fear among children with conduct problems. JAMA Psychiatry. 2014;71:627-636. https://doi.org/10.1001/jamapsychiatry.2013.4540
  18. Gansler DA, McLaughlin NC, Iguchi L, Jerram M, Moore DW, Bhadelia R, Fulwiler C. A multivariate approach to aggression and the orbital frontal cortex in psychiatric patients. Psychiatry Res. 2009;171:145-154. https://doi.org/10.1016/j.pscychresns.2008.03.007
  19. Antonucci AS, Gansler DA, Tan S, Bhadelia R, Patz S, Fulwiler C. Orbitofrontal correlates of aggression and impulsivity in psychiatric patients. Psychiatry Res. 2006;147(2-3):213-220. https://doi.org/10.1016/j.pscychresns.2005.05.016
  20. Boes AD, Tranel D, Anderson SW, Nopoulos P. Right anterior cingulate: a neuroanatomical correlate of aggression and defiance in boys. Behav Neurosci. 2008;122:677-684. https://doi.org/10.1037/0735-7044.122.3.677
  21. Ducharme S, Hudziak JJ, Botteron KN, Ganjavi H, Lepage C, Collins DL, Albaugh MD, Evans AC, Karama S; Brain Development Cooperative Group.Right anterior cingulate cortical thickness and bilateral striatal volume correlate with child behavior checklist aggressive behavior scores in healthy children. Biol Psychiatry. 2011;70:283-290. https://doi.org/10.1016/j.biopsych.2011.03.015
  22. Coccaro EF, McCloskey MS, Fitzgerald DA, Phan KL. Amygdala and orbitofrontal reactivity to social threat in individuals with impulsive aggression. Biol Psychiatry. 2007;62:168-178. https://doi.org/10.1016/j.biopsych.2006.08.024
  23. Hoptman MJ, D’Angelo D, Catalano D, Mauro CJ, Shehzad ZE, Kelly AM, Castellanos FX, Javitt DC, Milham MP. Amygdalofrontal functional disconnectivity and aggression in schizophrenia. Schizophr Bull. 2010;36:1020-1028. https://doi.org/10.1093/schbul/sbp012
  24. Fulwiler CE, King JA, Zhang N. Amygdala-orbitofrontal restingstate functional connectivity is associated with trait anger. Neuroreport. 2012;23:606-610. https://doi.org/10.1097/wnr.0b013e3283551cfc
  25. Haber SN. The primate basal ganglia: parallel and integrative networks. J Chem Neuroanat. 2003;26:317-330. https://doi.org/10.1016/j.jchemneu.2003.10.003
  26. Crockett MJ, Apergis-Schoute A, Herrmann B, Lieberman MD, Müller U, Robbins TW, Clark L. Serotonin modulates striatal responses to fairness and retaliation in humans. J Neurosci. 2013;33:3505-3513. https://doi.org/10.1523/jneurosci.2761-12.2013
  27. Brown GL, Goodwin FK, Ballenger JC, Goyer PF, Major LF. Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Res. 1979;1:131-139. https://doi.org/10.1016/0165-1781(79)90053-2
  28. Brown GL, Ebert MH, Goyer PF, Jimerson DC, Klein WJ, Bunney WE, Goodwin FK. Aggression, suicide, and serotonin: relationships to CSF amine metabolites. Am J Psychiatry. 1982;139:741-746. https://doi.org/10.1176/ajp.139.6.741
  29. Brown CS, Kent TA, Bryant SG, Gevedon RM, Campbell JL, Felthous AR, Barratt ES, Rose RM. Blood platelet uptake of serotonin in episodic aggression. Psychiatry Res. 1989;27:5-12. https://doi.org/10.1016/0165-1781(89)90003-6
  30. Stoff DM, Pollock L, Vitiello B, Behar D, Bridger WH. Reduction of (3H)-imipramine binding sites on platelets of conduct-disordered children. Neuropsychopharmacology. 1987;1:55-62. https://doi.org/10.1016/0893-133x(87)90010-8
  31. Coccaro EF, Astill JL, Herbert JL, Schut AG. Fluoxetine treatment of impulsive aggression in DSM-III-R personality disorder patients. J Clin Psychopharmacol. 1990;10:373-375. https://doi.org/10.1016/0893-133x(87)90010-8
  32. Coccaro EF, Kavoussi RJ. Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. Arch Gen Psychiatry. 1997;54:1081-1088. https://doi.org/10.1001/archpsyc.1997.01830240035005
  33. Bjork JM, Dougherty DM, Moeller FG, Cherek DR, Swann AC. The effects of tryptophan depletion and loading on laboratory aggression in men: time course and a food-restricted control. Psychopharmacology (Berl). 1999;142:24-30. https://doi.org/10.1007/s002130050858
  34. Bjork JM, Dougherty DM, Moeller FG, Swann AC. Differential behavioral effects of plasma tryptophan depletion and loading in aggressive and nonaggressive men. Neuropsychopharmacology. 2000;22:357-369. https://doi.org/10.1016/s0893-133x(99)00136-0
  35. Kramer UM, Riba J, Richter S, Munte TF. An fMRI study on the role of serotonin in reactive aggression. PLoS One. 2011;6:27668. https://doi.org/10.1371/journal.pone.0027668
  36. Yang J, Lee MS, Lee SH, Lee BC, Kim SH, Joe SH, Jung IK, Choi IG, Ham BJ. Association between tryptophan hydroxylase 2 polymorphism and anger-related personality traits among young Korean women. Neuropsychobiology. 2010;62:158-163. https://doi.org/10.1159/000318572
  37. Yoon HK, Lee HJ, Kim L, Lee MS, Ham BJ. Impact of tryptophan hydroxylase 2 G-703T polymorphism on anger-related personality traits and orbitofrontal cortex. Behav Brain Res. 2012;231:105-110. https://doi.org/10.1016/j.bbr.2012.03.001
  38. Gutknecht L, Jacob C, Strobel A, Kriegebaum C, Müller J, Zeng Y, Markert C, Escher A, Wendland J, Reif A, Mössner R, Gross C, Brocke B, Lesch KP. Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation. Int J Neuropsychopharmacol. 2007;10:309-320. https://doi.org/10.1017/s1461145706007437
  39. Yu Q, Teixeira CM, Mahadevia D, Huang Y, Balsam D, Mann JJ, Gingrich JA, Ansorge MS. Dopamine and serotonin signaling during two sensitive developmental periods differentially impact adult aggressive and affective behaviors in mice. Mol Psychiatry. 2014;19:688-698. https://doi.org/10.1038/mp.2014.10
  40. Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D, Lesch KP. Allelic variation of human serotonin transporter gene expression. J Neurochem. 1996;66:2621-2624. https://doi.org/10.1046/j.1471-4159.1996.66062621.x
  41. May ME, Lightfoot DA, Srour A, Kowalchuk RK, Kennedy CH. Association between serotonin transporter polymorphisms and problem behavior in adult males with intellectual disabilities. Brain Res. 2010;1357:97-103. https://doi.org/10.1046/j.1471-4159.1996.66062621.x
  42. Witte AV, Flöel A, Stein P, Savli M, Mien LK, Wadsak W, Spindelegger C, Moser U, Fink M, Hahn A, Mitterhauser M, Kletter K, Kasper S, Lanzenberger R. Aggression is related to frontal serotonin-1A receptor distribution as revealed by PET in healthy subjects. Hum Brain Mapp. 2009;30:2558-2570. https://doi.org/10.1002/hbm.20687
  43. Conner TS, Jensen KP, Tennen H, Furneaux HM, Kranzler HR, Covault J. Functional polymorphisms in the serotonin 1B receptor gene (HTR1B) predict self-reported anger and hostility among young men. Am J Med Genet B Neuropsychiatr Genet. 2010;153B(1):67-78. https://doi.org/10.1002/ajmg.b.30955
  44. Giegling I, Hartmann AM, Moller HJ, Rujescu D. Anger- and aggression-related traits are associated with polymorphisms in the 5-HT-2A gene. J Affect Disord. 2006;96:75-81. https://doi.org/10.1016/j.jad.2006.05.016
  45. Bruce KR, Steiger H, Joober R, Ng Ying Kin NM, Israel M, Young SN. Association of the promoter polymorphism -1438G/A of the 5-HT2A receptor gene with behavioral impulsiveness and serotonin function in women with bulimia nervosa. Am J Med Genet B Neuropsychiatr Genet. 2005;137B(1):40-44. https://doi.org/10.1002/ajmg.b.30205
  46. Gatt JM, Williams LM, Schofield PR, Dobson-Stone C, Paul RH, Grieve SM, Clark CR, Gordon E, Nemeroff CB. Impact of the HTR3A gene with early life trauma on emotional brain networks and depressed mood. Depress Anxiety. 2010;27:752-759. https://doi.org/10.1002/da.20726
  47. Iidaka T, Ozaki N, Matsumoto A, et al. A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala. J Neurosci. 2005;25:6460-6466. https://doi.org/10.1523/jneurosci.5261-04.2005
  48. Schlüter T, Winz O, Henkel K, Prinz S, Rademacher L, Schmaljohann J, Dautzenberg K, Cumming P, Kumakura Y, Rex S, Mottaghy FM, Gründer G, Vernaleken I. The impact of dopamine on aggression: an [18F]-FDOPA PET Study in healthy males. J Neurosci. 2013;33:16889-16896. https://doi.org/10.1523/jneurosci.1398-13.2013
  49. Buckholtz JW, Treadway MT, Cowan RL, Woodward ND, Benning SD, Li R, Ansari MS, Baldwin RM, Schwartzman AN, Shelby ES, Smith CE, Cole D, Kessler RM, Zald DH. Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits. Nat Neurosci. 2010;13:419-421. https://doi.org/10.1038/nn.2510
  50. Vevera J, Stopkova R, Bes M, Albrecht T, Papezova H, Zukov I, Raboch J, Stopka P. COMT polymorphisms in impulsively violent offenders with antisocial personality disorder. Neuro Endocrinol Lett. 2009;30:753-756.
  51. Hirata Y, Zai CC, Nowrouzi B, Beitchman JH, Kennedy JL. Study of the catechol-o-methyltransferase (COMT) gene with high aggression in children. Aggress Behav. 2013;39:45-51. https://doi.org/10.1002/ab.21448
  52. Fresan A, Camarena B, Apiquian R, Aguilar A, Urraca N, Nicolini H. Association study of MAO-A and DRD4 genes in schizophrenic patients with aggressive behavior. Neuropsychobiology. 2007;55:171-175. https://doi.org/10.1159/000106477
  53. Buchmann AF, Zohsel K, Blomeyer D, Hohm E, Hohmann S, Jennen-Steinmetz C, Treutlein J, Becker K, Banaschewski T, Schmidt MH, Esser G, Brandeis D, Poustka L, Zimmermann US, Laucht M. Interaction between prenatal stress and dopamine D4 receptor genotype in predicting aggression and cortisol levels in young adults. Psychopharmacology (Berl). 2014;231:3089-3097. https://doi.org/10.1007/s00213-014-3484-7
  54. Bosch OJ, Neumann ID. Vasopressin released within the central amygdala promotes maternal aggression. Eur J Neurosci. 2010;31:883-891. https://doi.org/10.1111/j.1460-9568.2010.07115.x
  55. Wersinger SR, Caldwell HK, Christiansen M, Young WS III. Disruption of the vasopressin 1b receptor gene impairs the attack component of aggressive behavior in mice. Genes Brain Behav. 2007;6:653-660. https://doi.org/10.1111/j.1601-183x.2006.00294.x
  56. Wersinger SR, Ginns EI, O’Carroll AM, Lolait SJ, Young WS III. Vasopressin V1b receptor knockout reduces aggressive behavior in male mice. Mol Psychiatry. 2002;7(9):975-984. https://doi.org/10.1038/sj.mp.4001195
  57. Guastella AJ, Kenyon AR, Alvares GA, Carson DS, Hickie IB. Intranasal arginine vasopressin enhances the encoding of happy and angry faces in humans. Biol Psychiatry. 2010;67:1220-1222. https://doi.org/10.1016/j.biopsych.2010.03.014
  58. Luppino D, Moul C, Hawes DJ, Brennan J, Dadds MR. Association between a polymorphism of the vasopressin 1B receptor gene and aggression in children. Psychiatr Genet. 2014;24:185-190. https://doi.org/10.1097/ypg.0000000000000036
  59. Zai CC, Muir KE, Nowrouzi B, Shaikh SA, Choi E, Berall L, Trépanier MO, Beitchman JH, Kennedy JL. Possible genetic association between vasopressin receptor 1B and child aggression. Psychiatry Res. 2012;200:784-788. https://doi.org/10.1016/j.psychres.2012.07.031
  60. Vogel F, Wagner S, Başkaya O, Leuenberger B, Mobascher A, Dahmen N, Lieb K, Tadić A. Variable number of tandem repeat polymorphisms of the arginine vasopressin receptor 1A gene and impulsive aggression in patients with borderline personality disorder. Psychiatr Genet. 2012;22:105-106. https://doi.org/10.1097/ypg.0b013e32834accad
  61. Derntl B, Windischberger C, Robinson S, Kryspin-Exner I, Gur RC, Moser E, Habel U. Amygdala activity to fear and anger in healthy young males is associated with testosterone. Psychoneuroendocrinology. 2009;34:687-693. https://doi.org/10.1016/j.psyneuen.2008.11.007
  62. Hermans EJ, Ramsey NF, van Honk J. Exogenous testosterone enhances responsiveness to social threat in the neural circuitry of social aggression in humans. Biol Psychiatry. 2008;63:263-270. https://doi.org/10.1016/j.biopsych.2007.05.013
  63. van Wingen G, Mattern C, Verkes RJ, Buitelaar J, Fernández G. Testosterone reduces amygdala-orbitofrontal cortex coupling. Psychoneuroendocrinology. 2010;35:105-113. https://doi.org/10.1016/j.psyneuen.2009.09.007
  64. Fenwick P. The nature and management of aggression in epilepsy. J Neuropsychiatry Clin Neurosci. 1989;1:418-425. https://doi.org/10.1176/jnp.1.4.418
  65. Lin JJ, Mula M, Hermann BP. Uncovering the neurobehavioural comorbidities of epilepsy over the lifespan. Lancet. 2012;380:1180-1192. https://doi.org/10.1016/s0140-6736(12)61455-x
  66. Brodie MJ, Besag F, Ettinger AB, Mula M, Gobbi G, Comai S, Aldenkamp AP, Stenhoff BJ. Epilepsy, Antiepileptic Drugs, and Aggression: An Evidence-Based Reviews. Pharmacol Rev. 2016;68(3):563-602. https://doi.org/10.1124/pr.115.012021
  67. Hughes J, Devinsky O, Feldmann E, Bromfield E. Premonitory symptoms in epilepsy. Seizure. 1993;2:201-203. https://doi.org/10.1016/s1059-1311(05)80128-1
  68. Devinsky O. Psychiatric comorbidity in patients with epilepsy: implications for diagnosis and treatment. Epilepsy Behav. 2003;4(suppl 4):2-10. https://doi.org/10.1016/j.yebeh.2003.10.002
  69. Delgado-Escueta AV, Mattson RH, King L, Goldensohn ES, Spiegel H, Madsen J, Crandall P, Dreifuss F, Porter RJ. Special report. The nature of aggression during epileptic seizures. N Engl J Med. 1981;305:711-716. https://doi.org/10.1056/nejm198109173051231
  70. Marsh L, Krauss GL. Aggression and violence in patients with epilepsy. Epilepsy Behav. 2000;1:160-168. https://doi.org/10.1006/ebeh.2000.0061
  71. Bronsard G, Bartolomei F. Rhythms, rhythmicity and aggression. J Physiol Paris. 2013;107:327-334. https://doi.org/10.1016/j.jphysparis.2013.03.002
  72. So NK, Savard G, Andermann F, Olivier A, Quesney LF. Acute postictal psychosis: a stereo EEG study. Epilepsia. 1990;31:188-193. https://doi.org/10.1111/j.1528-1167.1990.tb06305.x
  73. Kanemoto K, Tadokoro Y, Oshima T. Violence and postictal psychosis: a comparison of postictal psychosis, interictal psychosis, and postictal confusion. Epilepsy Behav. 2010;19:162-166.
  74. Rodin EA. Psychomotor epilepsy and aggressive behavior. Arch Gen Psychiatry. 1973;28:210-213. https://doi.org/10.1001/archpsyc.1973.01750320044007
  75. Currie S, Heathfield KW, Henson RA, Scott DF. Clinical course and prognosis of temporal lobe epilepsy. A survey of 666 patients. Brain. 1971;94:173-190. https://doi.org/10.1093/brain/94.1.173
  76. Piazzini A, Turner K, Edefonti V, Bravi F, Canevini MP, Ferraroni M. LICE Irritability Group. A new Italian instrument for the assessment of irritability in patients with epilepsy. Epilepsy Behav. 2011;21:275-281. https://doi.org/10.1016/j.yebeh.2011.04.051
  77. van Elst LT, Woermann FG, Lemieux L, Thompson PJ, Trimble MR. Affective aggression in patients with temporal lobe epilepsy: a quantitative MRI study of the amygdala. Brain. 2000;123:234-243. https://doi.org/10.1093/brain/123.2.234
  78. Woermann FG, van Elst LT, Koepp MJ, Free SL, Thompson PJ, Trimble MR, Duncan JS. Reduction of frontal neocortical grey matter associated with affective aggression in patients with temporal lobe epilepsy: an objective voxel by voxel analysis of automatically segmented MRI. J Neurol Neurosurg Psychiatry. 2000;68:162-169. https://doi.org/10.1136/jnnp.68.2.162
  79. Stadnyuk YuI, Vorob’eva OV. Psychological aspects of interictal aggression in patients with temporal epilepsy. Vestnik Nevrologii, Psikhiatrii i Neirokhirurgii. 2016;10:48-55. (In Russ.)
  80. Ketter TA, Post RM, Theodore WH. Positive and negative psychiatric effects of antiepileptic drugs in patients with seizure disorders. Neurology. 1999;53(suppl 2):53-67.
  81. Nadkarni S, Devinsky O. Psychotropic effects of antiepileptic drugs. Epilepsy Curr. 2005;5:176-181. https://doi.org/10.1111/j.1535-7511.2005.00056.x
  82. Helmstaedter C, Mihov Y, Toliat MR, Thiele H, Nuernberg P, Schoch S, Surges R, Elger CE, Kunz WS, Hurlemann R. Genetic variation in dopaminergic activity is associated with the risk for psychiatric side effects of levetiracetam. Epilepsia. 2013;54:36-44. https://doi.org/10.1111/j.1528-1167.2012.03603.x
  83. Krishnamoorthy ES, Trimble MR, Sander JW, Kanner AM. Forced normalization at the interface between epilepsy and psychiatry. Epilepsy Behav. 2002;3:303-308. https://doi.org/10.1016/s1525-5050(02)00052-5
  84. Wieshmann UC, Tan GM, Baker G. Self-reported symptoms in patients on antiepileptic drugs in monotherapy. Acta Neurol Scand. 2011;124:355-358. https://doi.org/10.1111/j.1600-0404.2011.01488.x
  85. Monroe R. Episodic behaviour disorder. Boston: Harvard University Press; 1970.
  86. Ribot R, Ouyang B, Kanner AM. The impact of antidepressants on seizure frequency and depressive and anxiety disorders of patients with epilepsy: Is it worth invistagating? Epilepsy Behav. 2017;10:70(Pt A):5-9. https://doi.org/10.1016/j.yebeh.2017.02.032
  87. Yudofsky SC, Silver JM, Hales RE. Treatment of agitation and aggression. In: Yudofsky SC, Hales RE, editors. The American psychiatric press textbook of neuropsychiatry. Washington, DC: American Psychiatric Press; 1997.

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