Olfactory neuroepithelium as a model for the studies of molecular mechanisms of schizophrenia

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Krukov A.I.

Sverzhevsky Moscow Scientific and Practical Othorhinolaryngology Center, Moscow

Kostyuk G.P.

Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russia, Institute of Medical and Social Technologies, Moscow, Russia, Alekseev Psychiatric Clinical Hospital №1, Moscow, Russia

SPIN RSCI: 3424-4544
Scopus AuthorID: 57200081884
ORCID: 0000-0002-3073-6305

Arzamasov S.G.

Sverzhevskiy Otorhinolaryngology Healthcare Research Institute, Moscow Department of Healthcare, Moscow, Russia

Tsarapkin G.Yu.

Sverzhevskiy Otorhinolaryngology Healthcare Research Institute, Moscow Department of Healthcare, Moscow, Russia

ORCID: 0000-0003-2349-7438

Olfactory neuroepithelium as a model for the studies of molecular mechanisms of schizophrenia

Authors:

Golimbet V.E., Krukov A.I., Kostyuk G.P., Arzamasov S.G., Tsarapkin G.Yu.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(6): 111‑114

DOI: 10.17116/jnevro201811861111

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To cite this article:

Golimbet VE, Krukov AI, Kostyuk GP, Arzamasov SG, Tsarapkin GYu. Olfactory neuroepithelium as a model for the studies of molecular mechanisms of schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(6):111‑114. (In Russ.)
https://doi.org/10.17116/jnevro201811861111

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

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Olfactory neuroepithelium (OE) is shown to be a suitable experimental model to study neuronal biomarkers of psychiatric diseases including schizophrenia. Olfactory neuronal precursors can be useful for studying neurodevelopmental stages, neuronal markers, pharmacological screening. However, a limited number of research groups have used this cell model in a small number of patients and healthy people that can be explained by several factors. Based on literature reports and own research, the authors analyze the advantages and limitations of OE-derived cell/tissue models. The main limitations of these models are decreased rate of harvesting and culturing OE-derived cell and low percentage of patients who agreed to participate in the study. Our results showed that only 10% of patients with schizophrenia signed informed consent for nasal biopsy, 80% of them underwent biopsy.

Keywords:

neuron

schizophrenia

nasal biopsy

methylation

gene expression

Authors:

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Krukov A.I.

Sverzhevsky Moscow Scientific and Practical Othorhinolaryngology Center, Moscow

Kostyuk G.P.

SPIN RSCI: 3424-4544
Scopus AuthorID: 57200081884
ORCID: 0000-0002-3073-6305

Arzamasov S.G.

Sverzhevskiy Otorhinolaryngology Healthcare Research Institute, Moscow Department of Healthcare, Moscow, Russia

Tsarapkin G.Yu.

Sverzhevskiy Otorhinolaryngology Healthcare Research Institute, Moscow Department of Healthcare, Moscow, Russia

ORCID: 0000-0003-2349-7438

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