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Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Krukov A.I.

Sverzhevsky Moscow Scientific and Practical Othorhinolaryngology Center, Moscow

Kostyuk G.P.

Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russia, Institute of Medical and Social Technologies, Moscow, Russia, Alekseev Psychiatric Clinical Hospital №1, Moscow, Russia

Arzamasov S.G.

Sverzhevskiy Otorhinolaryngology Healthcare Research Institute, Moscow Department of Healthcare, Moscow, Russia

Tsarapkin G.Yu.

Sverzhevskiy Otorhinolaryngology Healthcare Research Institute, Moscow Department of Healthcare, Moscow, Russia

Olfactory neuroepithelium as a model for the studies of molecular mechanisms of schizophrenia

Authors:

Golimbet V.E., Krukov A.I., Kostyuk G.P., Arzamasov S.G., Tsarapkin G.Yu.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(6): 111‑114

DOI: 10.17116/jnevro201811861111

Read: 2486 times

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Table of contents

OLFACTORY NEUROEPITHELIUM AS A MODEL FOR THE STUDIES OF MOLECULAR MECHANISMS OF SCHIZOPHRENIA
OLFACTORY NEUROEPITHELIUM AS A MODEL FOR THE STUDIES OF MOLECULAR MECHANISMS OF SCHIZOPHRENIA

To cite this article:

Golimbet VE, Krukov AI, Kostyuk GP, Arzamasov SG, Tsarapkin GYu. Olfactory neuroepithelium as a model for the studies of molecular mechanisms of schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(6):111‑114. (In Russ.)
https://doi.org/10.17116/jnevro201811861111

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Abstract:

Olfactory neuroepithelium (OE) is shown to be a suitable experimental model to study neuronal biomarkers of psychiatric diseases including schizophrenia. Olfactory neuronal precursors can be useful for studying neurodevelopmental stages, neuronal markers, pharmacological screening. However, a limited number of research groups have used this cell model in a small number of patients and healthy people that can be explained by several factors. Based on literature reports and own research, the authors analyze the advantages and limitations of OE-derived cell/tissue models. The main limitations of these models are decreased rate of harvesting and culturing OE-derived cell and low percentage of patients who agreed to participate in the study. Our results showed that only 10% of patients with schizophrenia signed informed consent for nasal biopsy, 80% of them underwent biopsy.

Keywords:

neuron
schizophrenia
nasal biopsy
methylation
gene expression

Authors:

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Krukov A.I.

Sverzhevsky Moscow Scientific and Practical Othorhinolaryngology Center, Moscow

Kostyuk G.P.

Serbsky Federal Medical Research Center for Psychiatry and Narcology, Moscow, Russia, Institute of Medical and Social Technologies, Moscow, Russia, Alekseev Psychiatric Clinical Hospital №1, Moscow, Russia

Arzamasov S.G.

Sverzhevskiy Otorhinolaryngology Healthcare Research Institute, Moscow Department of Healthcare, Moscow, Russia

Tsarapkin G.Yu.

Sverzhevskiy Otorhinolaryngology Healthcare Research Institute, Moscow Department of Healthcare, Moscow, Russia

Close metadata

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