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Shishov A.S.

Klinicheskiĭ otdel Instituta poliomielita i virusnykh éntsefalitov im. M.P. Chumakova RAMN, Infektsionnaia klinicheskaia bol'nitsa #1, Moskva

Ivanova O.E.

Shakarian A.K.

Kozlovskaya L.I.

Chumakov Federal Scientific Center for Research and Development of Immune-and-biological Products of Russian Academy of Sciences, Moscow, Russia;
Infectious clinical hospital №1, Moscow, Russia

Mitrofanova I.V.

Municipal Clinical Hospital №1, Department of Health Care, Moscow, Russia

Shachgildyan S.V.

Chumakov Federal Scientific Center for Research and Development of Immune-and-biological Products of Russian Academy of Sciences, Moscow, Russia;
Sechenov First Moscow State Medical University, Moscow, Russia

A case of vaccine-associated paralytic poliomyelitis in an infant

Authors:

Shishov A.S., Ivanova O.E., Shakarian A.K., Kozlovskaya L.I., Mitrofanova I.V., Shachgildyan S.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(4): 84‑89

DOI: 10.17116/jnevro20181184184-89

Read: 39224 times

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Table of contents

A CASE OF VACCINE-ASSOCIATED PARALYTIC POLIOMYELITIS IN AN INFANT
A CASE OF VACCINE-ASSOCIATED PARALYTIC POLIOMYELITIS IN AN INFANT

To cite this article:

Shishov AS, Ivanova OE, Shakarian AK, Kozlovskaya LI, Mitrofanova IV, Shachgildyan SV. A case of vaccine-associated paralytic poliomyelitis in an infant. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(4):84‑89. (In Russ.)
https://doi.org/10.17116/jnevro20181184184-89

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Objective. To present the clinical history, vaccination status, features of the clinical picture, composition of the cerebrospinal fluid (CSF), results of laboratory and instrumental examinations of a patient with vaccine-associated paralytic poliomyelitis (VAPP). Material and methods. In 2017, a child, aged 15 month, mistakenly vaccinated with the first dose of bivalent (types 1 & 3) polioviruses oral vaccine (OPV) was followed up. Results and conclusion. Clinical parameters of VAPP in the recipient of OPV are considered. Clinical features of disease caused by wild poliovirus and VAPP are compared. The disease was characterized by sudden onset, recurrence, short (2—4 days) period of progression of paresis, persistent residual effects, CSF protein-cell dissociation. It is emphasized that the occurrence of VAPP cases reflects primarily immunization defects.

Keywords:

vaccine associated paralytic poliomyelitis
clinical picture
cerebrospinal fluid
virological examination

Authors:

Shishov A.S.

Klinicheskiĭ otdel Instituta poliomielita i virusnykh éntsefalitov im. M.P. Chumakova RAMN, Infektsionnaia klinicheskaia bol'nitsa #1, Moskva

Ivanova O.E.

Shakarian A.K.

Kozlovskaya L.I.

Chumakov Federal Scientific Center for Research and Development of Immune-and-biological Products of Russian Academy of Sciences, Moscow, Russia;
Infectious clinical hospital №1, Moscow, Russia

Mitrofanova I.V.

Municipal Clinical Hospital №1, Department of Health Care, Moscow, Russia

Shachgildyan S.V.

Chumakov Federal Scientific Center for Research and Development of Immune-and-biological Products of Russian Academy of Sciences, Moscow, Russia;
Sechenov First Moscow State Medical University, Moscow, Russia

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References:

  1. Chumakov MP, Voroshilova MK, Drozdov SG, Dzagurov SG, Lashkevich VA, Mironova LL, Ralf NM, Gagarina AV, Dobrova IN, Aschmarina EE, Shirman GA, Fleer GP, Tolskaya EA, Sokolova IS, Elbert LB, Sinyak KM. Some results of the works on mass immunization in the Soviet Union with live poliovirus prepared vaccine from Sabin strains. Vestnik AMS USSR. 1961;4:30-43. (In Russ.)
  2. Drozdov SG, Ivanova ОЕ. Poliomyelitis. Voprosy virusologii. 2012;1:76-90. (In Russ.)
  3. Lashkevich VA. History of Development of the Live Poliomyelitis Vaccine from Sabin Attenuated Strains in 1959 and Idea of Poliomyelitis Eradication . Voprosy virusologii. 2013;4:4-10. (In Russ.)
  4. Leshchinskaya EV, Latysheva IT. The Clinic, Diagnosis and Treatment of Acute Poliomyelitis. Metodicheskie rekomendatsii. M. 1998. (In Russ.)
  5. Resolution of the 41st World Health Assembly WHA 41.28. Global Eradication of poliomyelitis by the year 2000. 1988; HO, Geneva. http://www.who.int/ihr/polioresolution4128en.pdf
  6. Polio vaccines: WHO position paper — March, 2016. Wkly Epidemiol Rec. 2016;91(12):145-168.
  7. WHO. Polio Eradication and Endgame Strategic Plan 2013—2018. http://www.polioeradication.org/Portals/0/Document/Resources/StrategyWork/PEESP_EN_A4.pdf
  8. Kozlovskaya LI. Epidemiological situation in the world and in Russia in 2014. Medical Virology. 2014;XXVIII(3):20-24. (In Russ.)
  9. Shyshov AS, Saifullin MA, Shakaryan AK, Ivanova OE, Sachkova IYu. A case of poliovirus infection caused by a wild strain in the adult patient. Zhurn Nevrol i psikhiat im. S.S. Korsakova. 2011;111:10:77-80. (In Russ.)
  10. Yakovenko ML, Gmyl AP, Ivanova OE, Eremeeva TP, Ivanov AP, Prostova MA, Baykova OY, Isaeva OV, Lipskaya GY, Shakaryan AK, Kew OM, Deshpande JM, Agol VI. The 2010 outbreak of poliomyelitis in Tajikistan: epidemiology and lessons learnt. Euro Surveill. 2014;7:20706. Available at: http://www.eurosurveillance.org/VievArticle.aspx?Articled=20706
  11. Vzorov AN. New immunogen to indicatii neutralizing antibodies and extra protection against HIV-1 infection: Dis... d-ra biol. nauk. M. 2016. Available at: http://dlib.rsl.ru/01006660442 (In Russ.)
  12. Leshchinskaya ЕV, Ivanova OE, Eremeeva TP, Sadovnikova VN. Cases of vaccine-associated paralytic poliomyelitis in Russia in 2000—2002. Ross Med Zhurn. 2004;3:19-24. (In Russ.)
  13. Ivanova OE, Eremeeva TP. Review of the data of vaccine-associated paralytic poliomyelitis. Medical Virology. 2006;XXIII:21-30. (In Russ.)
  14. Ivanova OE. Polio-Today: State of the Global Eradication Program and Modern Strategy of WHO on Immunization. Epidemiol. i vaktsinoprofil. 2015;2:73-79. (In Russ.)
  15. Bartoshevich EN. Poliomyelitis. M. 1958. (In Russ.)
  16. Platt LR, Estivariz CF, Sutter RW. Vaccine-associated paralytic poliomyelitis: a review of the epidemiology and estimation of the global burden. J Infect Dis. 2014;210(1):380-389.
  17. Agol VI. Paradox of Sabin vaccine. Medical Virology. 2006;XXIII:7-14. (In Russ.)
  18. Ivanova OE, Eremeeva TP, Leshchinskaya ЕV, Korotkova EA, Yakovenko ML, Cherkasova EA, Chernjavskaja OP, Krasnoproschina LI, Dragunskaya EM. The cases of poliomyelitis in Russia in 1998—2004. Medical Virology. 2006;XXIII:31-42. (In Russ.)
  19. World Health Organization (WHO) Manual for the virological investi gation of polio, 4th ed. Geneva: WHO; 2004. Available at: http://whqlibdoc.who.int/hq/2004/WHO_IVB_04.10.pdf.
  20. World Health Organization (WHO) Manual for virological investigation of poliomyelitis. WHO/EPI/GEN/97.1.Geneva; 1997.
  21. Ivanova OE, Eremeeva TP, Morozova NS, Shakaryan AK, Gmyl AP, Yakovenko ML, Korotkova EA, Chernjavskaja OP, Baykova OYu, Silenova OV, Krasota AYu, Krasnoproschina LI, Mustafina AN, Kozlovskaja LI. Vaccine-associated paralytic poliomyelitis in Russian Federation during the period of changes in vaccination schedule (2006—2013 yy.). Voprosy virusologii. 2016;1:9-15. (In Russ.) https://doi.org/10.18821/0507-4088-2016-61-1-9-15
  22. ICD-10. WHO: Geneva; 1995;1: 1-698. (In Russ.)
  23. Mel’nichuk PV, Shtul’man DR. Infectious and parasitic diseases of nervous system. V kn.: Bolezni nervnoi sistemy. Pod red. Yakhno N.N. Izd. 4-e. T. 1. M.: Meditsina; 2007. (In Russ.)
  24. Debre R, Thieffry S. The simptomatologie and diagnosis of Poliomyelitis. V kn.: Poliomielytis. Per. s angl. M.: Medgiz; 1957. (In Russ.)
  25. Sabin AB. Poliomyelitis vaccination in developing countries. Bulletin WHO. 1980;58(1):114-132. (In Russ.)
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